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Alkaloids and application of same to induction of accumulation of tanshinone in hairy roots of Salvia miltiorrhiza

A technology of tanshinone and alkaloid, applied in the field of chemistry, can solve the problem that the active ingredients of salvia miltiorrhiza cannot reach the level of crude drugs, etc.

Inactive Publication Date: 2018-12-14
杨博
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its ability to accumulate active components of Danshen, especially salvianolic acid and tanshinone, has not been able to reach the crude drug level.

Method used

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  • Alkaloids and application of same to induction of accumulation of tanshinone in hairy roots of Salvia miltiorrhiza
  • Alkaloids and application of same to induction of accumulation of tanshinone in hairy roots of Salvia miltiorrhiza
  • Alkaloids and application of same to induction of accumulation of tanshinone in hairy roots of Salvia miltiorrhiza

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Embodiment Construction

[0041] The substantive content of the present invention will be described in detail below in conjunction with the accompanying drawings and embodiments, but those skilled in the art should know that the protection scope of the present invention is not limited thereto.

[0042] 1. Experimental materials

[0043] The chemical structures of the alkaloids used in this example are shown in the table below, and the purity is not less than 95%.

[0044]

[0045]

[0046] The hairy root of Salvia miltiorrhiza used in this experiment was obtained by infecting the aseptic seedling of Salvia miltiorrhiza with Agrobacterium rhizogenes LBA9402, and subcultured in MSoH liquid medium at 25°C in a dark room.

[0047] 2. Experimental method

[0048] 1. Cultivation of hairy roots of Salvia miltiorrhiza

[0049] The hairy root of Salvia miltiorrhiza used in this experiment was obtained by infecting the aseptic seedling of Salvia miltiorrhiza with Agrobacterium rhizogenes LBA9402, and sub...

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Abstract

The invention discloses alkaloids and application of the same to induction of accumulation of tanshinone in the hairy roots of Salvia miltiorrhiza. It is found in the invention that Meiluokening B, Meiluokening C, Meiluokening G and Meiluokening H can significantly induce the accumulation of salvianolic acid in the hairy roots of Salvia miltiorrhiza, but have no significant effect on the accumulation of tanshinone; on the contrary, Meiluokening J and Leuconolam can significantly induce the accumulation of tanshinone in the hairy roots of Salvia miltiorrhiza, but have no obvious effect on the accumulation of salvianolic acid; however, Meiluokening A can induce the accumulation of both salvianolic acid and tanshinone in the hairy roots of Salvia miltiorrhiza.

Description

technical field [0001] The invention belongs to the field of chemistry, and relates to an alkaloid and its application in inducing the accumulation of tanshinone in the hairy root of salvia miltiorrhiza. Background technique [0002] Danshen, also known as red ginseng and Dahongpao, is one of the main bulk medicinal materials in my country. Salvia miltiorrhiza has the effects of promoting blood circulation and removing blood stasis, promoting menstruation and relieving pain, clearing heart and eliminating troubles, cooling blood and eliminating carbuncle, and can be used for the treatment of upset, insomnia, irregular menstruation, sores, swelling and pain. At present, the demand for salvia miltiorrhiza is increasing year by year. However, at present, the varieties of Danshen in China are mixed, the germplasm is seriously degraded, and the content of active ingredients is extremely unstable. In recent years, breakthroughs have been made in the production of various active ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/22C07J73/00A01H4/00
CPCC07D471/22A01H4/001C07B2200/07C07J73/008
Inventor 杨博谈荣慧李晓念
Owner 杨博
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