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Preparation method of melatonin micro-needle patch

A technology of melatonin and microneedle patch, which is applied in the field of preparation of melatonin microneedle patch, which can solve the problems of uncomfortable administration, low bioavailability, deposition of microneedle materials, etc., and achieve good skin compatibility and application wide range of effects

Active Publication Date: 2018-12-18
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many studies on soluble microneedles, hydrogel microneedles, and responsive microneedles, but soluble microneedles will cause deposition of microneedle materials in the skin, which is not suitable for frequent drug administration; responsive microneedles require a large amount of oxidative enzymes, biological Low utilization; chemically cross-linked hydrogel microneedles are used to avoid drug inactivation caused by chemical cross-linking, so the drug is loaded on the backing layer, resulting in low bioavailability

Method used

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  • Preparation method of melatonin micro-needle patch
  • Preparation method of melatonin micro-needle patch
  • Preparation method of melatonin micro-needle patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation of melatonin microneedles made of PVA, sodium carboxymethylcellulose and dextran

[0032] Prepare the mixed solution of PVA solution and sodium carboxymethyl cellulose and dextran respectively;

[0033] After mixing the mixed solution of melatonin, PVA solution, sodium carboxymethylcellulose and dextran, it is poured onto a polytetrafluoroethylene mold with a microhole array, and the back of the mold is vacuumed to make the The liquid medicine is completely filled into the micropores, and then a backing layer prepared from a polymer solution is laid on the front of the mold, and the mold and the backing layer loaded with the liquid medicine are subjected to two freeze-thaw cycle operations together , separating the microneedles together with the backing layer from the mold, and finally drying the microneedles to obtain the melatonin microneedle patch.

Embodiment 2

[0035] Preparation of melatonin microneedles made of PVA, sodium carboxymethylcellulose and dextran

[0036] Prepare the mixed solution of PVA solution and sodium carboxymethyl cellulose and dextran respectively;

[0037] Mix the mixed solution of melatonin, PVA solution, sodium carboxymethylcellulose and dextran, wherein the solid content of PVA accounts for 5%. Pour the mixed liquid medicine on the polytetrafluoroethylene mold with micro-hole array, vacuumize the back of the mold, so that the liquid medicine can be completely filled into the micro-holes, and then spread a layer on the front of the mold The backing layer prepared by polymer solution is used to freeze and thaw the mold and the backing layer loaded with the liquid medicine twice, and the microneedles and the backing layer are separated from the mold. It is difficult to remove the film and the liquid medicine is uniform remain in the mold.

Embodiment 3

[0039] Preparation of melatonin microneedles made of PVA, sodium carboxymethylcellulose and dextran

[0040] Prepare the mixed solution of PVA solution and sodium carboxymethyl cellulose and dextran respectively;

[0041] Mix the mixed solution of melatonin, PVA solution, sodium carboxymethylcellulose and dextran, wherein the solid content of PVA accounts for 11%. After pouring the mixed medicinal solution, it is poured onto a polytetrafluoroethylene mold with a microhole array, and the back of the mold is vacuumed so that the medicinal solution can be completely filled into the micropores, and then spread on the front of the mold. The upper layer is made of a backing layer made of a polymer solution. The mold and the backing layer loaded with the drug solution are frozen and thawed together for multiple times, and the microneedles and the backing layer are separated from the mold to realize the film removal. , and finally dry the microneedles to obtain the melatonin micronee...

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Abstract

The invention provides a preparation method of a melatonin micro-needle patch, which includes the steps of: pouring a polymer material water solution containing the melatonin on a mold provided with micropore matrix, so that the polymer material water solution fills the micropores in the mold; adhering a prefabricated back lining on the mold so that the back lining is adhered on the back side of the melatonin micro-needles formed in the micropores; then freezing and de-freezing the product, stripping off the film, and drying the product to obtain the melatonin micro-needle patch.

Description

technical field [0001] The invention relates to a method for preparing a melatonin microneedle patch, which belongs to the technical field of transdermal drug delivery systems. Background technique [0002] Melatonin has the functions of improving sleep, delaying aging, anti-oxidative damage, anti-tumor, treating Parkinson's disease, etc., and has broad application prospects. Since melatonin was discovered in 1953, many scientific researchers have been exploring and confirming its extensive physiological functions and mechanism of action. The most common way of administering melatonin is oral administration, but the hepatic first-pass effect is strong and the bioavailability is low. It is expected to improve its bioavailability; at the same time, microneedles are suitable for elderly people who cannot take oral administration. [0003] Microneedles refer to small needle arrays with a length less than 1mm, which can penetrate the stratum corneum, the main barrier of transde...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/4045A61K47/32A61K47/38A61K47/36A61K47/10A61P25/20A61P39/06A61P35/00A61P25/16
CPCA61K9/0021A61K31/4045A61K47/10A61K47/32A61K47/36A61K47/38A61P25/16A61P25/20A61P35/00A61P39/06
Inventor 吴飞刘锋金拓
Owner SHANGHAI JIAO TONG UNIV
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