The invention relates to 
imiquimod micro 
emulsion gels for local 
skin, at least comprising the following ingredients by 
mass percent: 0.1-2.5 percent of 
imiquimod, 1-24 percent of 
solvent, 1-16 percent of surface 
active agent, 1-12 percent of cosurfactant, 1-20 percent of gelatinizing agent and the remaining water; wherein the 
imiquimod is 1-isobutyl-1H-
imidazole(4,5-C) 
quinoline-4-amine; the preparation method comprises the following steps: the imiquimod is dissolved in the 
solvent, the surface 
active agent and the cosurfactant are added in the 
solvent dissolved with the imiquimod, and the mixture is dispersed uniformly; water with [roper amount is added in the mixture to form micro 
emulsion; the gelatinizing agent is swelled by water, so as to prepare the solution with a certain concentration, the gelatinizing agent solution is dropped in the imiquimod micro 
emulsion dropwise, the stirring is carried out while the gelatinizing agent solution is dropped, the pH value is adjusted by adding 
triethanolamine, so as to prepare the imiquimod micro emulsion gels; the invention has the advantages that: the thorough 
dispersity of the micro emulsion to medicines, adhesiveness of gels to the 
skin and deformation flowability thereof under external force are concentrated, so as to lead the 
medicine to be applied to the affected part and cause the 
medicine to pass into internal body and reach target spot through the 
skin; the 
medicine effect can act on continuously.