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110results about How to "Good skin compatibility" patented technology

Silica Composite Capsules Obtained By Blending Water-Soluble Silane Derivative, Composition Containg The Same, And Transparent Gel-Form Composition

The present invention provides new silica composite capsules that can be easily prepared, a composition containing the silica composite capsules, and a transparent gel-form composition excellent in appearance transparency and texture in use, and in particular, a transparent gel-form composition with improved cleansing properties when used as a cleanser. Micelle / silica composite capsules can easily be obtained, in an aqueous system, by mixing a material capable of forming micelles in water and a water-soluble silane derivative having a specific structure in aqueous solution. In addition, emulsion / silica composite capsules wherein the periphery of emulsion particles in the inner phase is coated with silica, can easily be obtained by mixing a surfactant, water, an oil, and a water-soluble silane derivative having a specific structure. Moreover, a transparent gel-form composition showing excellent appearance transparency, the texture in use and cleansing properties, can be obtained by blending a water-soluble silane derivative having a specific structure into the formulation that contains a surfactant, an oil and water, and capable of taking a surfactant association structure with aqueous continuous phase or both of aqueous continuous phase and oil continuous phase in the formulation.
Owner:SHISEIDO CO LTD

Imiquimod micro emulsion gels for local skin and preparation method thereof

The invention relates to imiquimod micro emulsion gels for local skin, at least comprising the following ingredients by mass percent: 0.1-2.5 percent of imiquimod, 1-24 percent of solvent, 1-16 percent of surface active agent, 1-12 percent of cosurfactant, 1-20 percent of gelatinizing agent and the remaining water; wherein the imiquimod is 1-isobutyl-1H-imidazole(4,5-C) quinoline-4-amine; the preparation method comprises the following steps: the imiquimod is dissolved in the solvent, the surface active agent and the cosurfactant are added in the solvent dissolved with the imiquimod, and the mixture is dispersed uniformly; water with [roper amount is added in the mixture to form micro emulsion; the gelatinizing agent is swelled by water, so as to prepare the solution with a certain concentration, the gelatinizing agent solution is dropped in the imiquimod micro emulsion dropwise, the stirring is carried out while the gelatinizing agent solution is dropped, the pH value is adjusted by adding triethanolamine, so as to prepare the imiquimod micro emulsion gels; the invention has the advantages that: the thorough dispersity of the micro emulsion to medicines, adhesiveness of gels to the skin and deformation flowability thereof under external force are concentrated, so as to lead the medicine to be applied to the affected part and cause the medicine to pass into internal body and reach target spot through the skin; the medicine effect can act on continuously.
Owner:HUAZHONG NORMAL UNIV
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