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A bicarbonate dialysate packaged in a double-chamber bag and preparation method thereof

A technology of bicarbonate and bag packaging, which is applied in the field of medicine, can solve unobserved problems, and achieve the effects of increasing safety and stability, good curative effect, and stable and reliable pH value

Active Publication Date: 2020-12-11
SHIJIAZHUANG NO 4 PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The results showed that, although there was no significant difference in acid-base status between the two groups overall, plasma bicarbonate concentrations increased in patients with prior acidosis in the bicarbonate group and decreased in patients with alkalosis, while lactate peridialysis fluid In patients on dialysis, this change was not observed

Method used

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  • A bicarbonate dialysate packaged in a double-chamber bag and preparation method thereof
  • A bicarbonate dialysate packaged in a double-chamber bag and preparation method thereof
  • A bicarbonate dialysate packaged in a double-chamber bag and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0037] (1) Concentrated preparation of the electrolyte solution in room A: put calcium chloride, magnesium chloride and lactic acid into water for injection respectively, stir to dissolve, add activated carbon, stir evenly, first filter through a 1.00 μm polyethersulfone filter element, and then pass through a 0.45 Filter with μm polyethersulfone filter element to obtain concentrated solution in room A;

[0038] (2) Dilute preparation of the electrolyte solution in room A: Add water for injection to the required amount to the concentrated solution in room A obtained in step (1), stir evenly, and filter through a polyethersulfone filter element with a pore size of 0.22 μm until the liquid medicine is clear Finally, adjust the pH value to 2.15 to obtain the electrolyte solution in room A;

[0039] (3) Concentrated preparation of buffer solution in room B: Put sodium bicarbonate and sodium chloride into water for injection respectively, stir and dissolve, add activated carbon, st...

Embodiment 2

[0043] (1) Concentrated preparation of the electrolyte solution in room A: put calcium chloride, magnesium chloride and lactic acid into water for injection respectively, stir to dissolve, add activated carbon, stir evenly, first filter through a 1.00 μm polyethersulfone filter element, and then pass through a 0.45 Filter with μm polyethersulfone filter element to obtain concentrated solution in room A;

[0044] (2) Dilute preparation of the electrolyte solution in room A: Add water for injection to the required amount to the concentrated solution in room A obtained in step (1), stir evenly, and filter through a polyethersulfone filter element with a pore size of 0.22 μm until the liquid medicine is clear Finally, the pH value was adjusted to 2.13 to obtain the electrolyte solution in room A;

[0045] (3) Concentrated preparation of buffer solution in room B: Put sodium bicarbonate and sodium chloride into water for injection respectively, stir and dissolve, add activated carb...

Embodiment 3

[0049] (1) Concentrated preparation of the electrolyte solution in room A: put calcium chloride, magnesium chloride and lactic acid into water for injection respectively, stir to dissolve, add activated carbon, stir evenly, first filter through a 1.00 μm polyethersulfone filter element, and then pass through a 0.45 Filter with μm polyethersulfone filter element to obtain concentrated solution in room A;

[0050] (2) Dilute preparation of the electrolyte solution in room A: Add water for injection to the required amount to the concentrated solution in room A obtained in step (1), stir evenly, and filter through a polyethersulfone filter element with a pore size of 0.22 μm until the liquid medicine is clear Finally, the pH value was adjusted to 2.13 to obtain the electrolyte solution in room A;

[0051] (3) Concentrated preparation of buffer solution in room B: Put sodium bicarbonate and sodium chloride into water for injection respectively, stir and dissolve, add activated carb...

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Abstract

The invention discloses a double-chamber bag-packed bicarbonate dialysis solution and a preparation method thereof. The double-chamber bag-packed bicarbonate dialysis solution is composed of an A-chamber electrolyte solution and a B-chamber buffer solution. The present invention simultaneously provides the preparation method of the bicarbonate dialysate packaged in the double-chamber bag, comprising the steps of concentrated and diluted electrolyte solution in chamber A and the step of concentrated and diluted buffer in chamber B, and The preparation step controls the pH values ​​of A chamber and B chamber respectively. The invention solves the precipitation problem of calcium carbonate or magnesium carbonate and improves the stability of the dialysate.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a double-chamber bag-packed bicarbonate dialysate and a preparation method thereof. Background technique [0002] Dialysis is one of the renal replacement therapies for patients with end-stage renal failure (ESRD). End-stage renal disease (ESRD) is a disease that seriously threatens human health. According to statistical results, the incidence of ESRD in my country is about 568 / million. Due to the limitation of kidney sources, high cost and rejection, kidney transplantation is not common in the treatment of end-stage renal disease. Dialysis therapy is the treatment of this disease in my country The main methods of the disease, which include hemodialysis (hemodialysis) and peritoneal dialysis (peritoneal dialysis) two. Peritoneal dialysis, especially continuous ambulatory peritoneal dialysis, is an effective method for the treatment of end-stage renal disease and is suitable for almost all ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/14A61P7/08A61M1/16A61K33/06A61K31/19A61K33/00
CPCA61K31/19A61K33/00A61K33/06A61K33/14A61M1/1654A61P7/08A61K2300/00
Inventor 殷殿书王立江闫记灵李士磊杨义牛丽静
Owner SHIJIAZHUANG NO 4 PHARMA
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