Oral preparation for preventing coronary heart disease

Abstract

The invention discloses an oral preparation for preventing coronary heart disease, which is prepared by the steps of extracting traditional Chinese medicine raw materials, including radix notoginseng,radix salviae milti orrhizae, herba rhodiolae sacrae, pericarpium citri reticulatae, fructus crataegi and flos chrysanthemi, preparing pharmaceutical composition powder from the extract, and finallypreparing the oral preparation from the pharmaceutical composition powder with propylene glycol as a solvent and phospholipid complex as absorption promoter. The oral preparation has the advantages that transmembrane transport of Panax Notoginseng Saponins, salvia acid B and salidroside is improved greatly, degradation of the oral preparation in gastrointestinal tract is reduced, and further oralabsorption of drug is improved; the oral preparation has functions such as tonifying qi and yin, promoting blood circulation to remove blood stasis, warming yang and dredging channels, clearing internal heat and facilitating bowel movement, and can improve physical health and delay senescence after long-term use; capsules and enteric capsules prepared from the oral preparation can be taken directly, without being decocted.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to an oral preparation for preventing coronary heart disease. Background technique [0002] Coronary heart disease is the abbreviation of coronary atherosclerotic heart disease. The coronary arteries supply the heart's own blood. Severe atherosclerosis or spasm occurs in the coronary arteries, which narrows or occludes the coronary arteries, leading to myocardial ischemia, hypoxia, or infarction. sick. The main clinical manifestations are angina pectoris and arrhythmia caused by myocardial ischemia and hypoxia. In severe cases, myocardial infarction may occur, resulting in extensive myocardial necrosis and life-threatening. [0003] At present, the clinical effect of treating coronary heart disease is not very satisfactory, so people pay more and more attention to the prevention of coronary heart disease. Among them, traditional Chinese medicine has the advantages of good curativ...

AI Technical Summary

Problems solved by technology

[0005] The active ingredient of Panax notoginseng is total saponins of Panax notoginseng, and the main component of total saponins of Panax notoginseng, ginsenosides, has a polyhydroxy structure and is a hydrophilic compound. Therefore, total saponins of Panax notoginseng have great water solubility and poor fat solubility. The low permeability of the mucous membrane, coupled with the degradation of the drug by the acidic environment of the gastric juice, the enzymatic hydrolysis of the gastrointestinal tract and bacterial metabolic enzymes, and the first-pass effect of the liver, make the pharmacological activity of the original drug impossible to achieve

[0006] The active ingredients of Salvia miltiorrhiza are mainly tanshinone IIA and salvianolic acid B, among which salvianolic acid B belongs to the class of drugs in the biopharmaceutical Ⅲ classification system, that is, it has good water solubility and poor biomembrane permeability, which is not conducive to the transmembrane absorption of drugs.

[0007] The active ingredients of Rhodiola are mainly salidroside and aglycone tyrosol, among which salidroside has good water solubility, poor biomembrane permeability, and is not conducive to the permeable membrane absorption of drugs