Oral preparation for preventing coronary heart disease

An oral preparation and a technology for coronary heart disease, which is applied in the field of oral preparations for preventing coronary heart disease, can solve the problems of the unrealizable pharmacological activity of the original drug, the large water solubility of Panax notoginseng saponins, and the low permeability of the gastrointestinal mucosa. The effect of oral absorption, improving taste, and convenience in taking

Inactive Publication Date: 2018-12-25
AFFILIATED HOSPITAL OF ZUNYI MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The active ingredient of Panax notoginseng is total saponins of Panax notoginseng, and the main component of total saponins of Panax notoginseng, ginsenosides, has a polyhydroxy structure and is a hydrophilic compound. Therefore, total saponins of Panax notoginseng have great water solubility and poor fat solubility. The low permeability of the mucous membrane, coupled with the degradation of the drug by the acidic environment of the gastric juice, the enzymatic hydrolysis of the gastrointestinal tract and bacterial metabolic enzymes, and the first-pass effect of the liver, make the pharmacological activity of

Method used

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Examples

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Embodiment 1

[0026] In the embodiment of the present invention, an oral preparation for preventing coronary heart disease is a medicament made of the following traditional Chinese medicine raw materials in the following weight ratio: Panax notoginseng 7, Salvia miltiorrhiza 4, Rhodiola rosea 5, Tangerine peel 8, Hawthorn 10 , white chrysanthemum 5.

[0027] Further, the preparation method of each raw material extract is as follows:

[0028] Radix Notoginseng Extract: Dry and crush Radix Notoginseng, extract in stages with industrial ethanol, filter and combine the filtrate, distill the filtrate to a certain amount under reduced pressure, add water and continue to distill until there is no alcohol smell, and then adjust to 1ml of medicinal liquid with water Equivalent to 1g of crude drug, pass the liquid through D 101 Macroporous adsorption resin column and elute with 50% ethanol, filter and cool, let the filtrate pass through a funnel covered with a small amount of neutral alumina, recove...

Embodiment 2

[0036] In the embodiment of the present invention, an oral preparation for preventing coronary heart disease is a medicament made of the following traditional Chinese medicine raw materials in the following weight ratio: Panax notoginseng 12, Salvia miltiorrhiza 8, Rhodiola rosea 10, Chenpi 12, Hawthorn 18 , white chrysanthemum 15.

[0037] Further, the preparation method of each raw material extract is as follows:

[0038] Radix Notoginseng Extract: Dry and crush Radix Notoginseng, extract in stages with industrial ethanol, filter and combine the filtrate, distill the filtrate to a certain amount under reduced pressure, add water and continue to distill until there is no alcohol smell, and then adjust to 1ml of medicinal liquid with water Equivalent to 1g of crude drug, pass the liquid through D 101 Macroporous adsorption resin column and elute with 50% ethanol, filter and cool, let the filtrate pass through a funnel covered with a small amount of neutral alumina, recover et...

Embodiment 3

[0046] In the embodiment of the present invention, an oral preparation for preventing coronary heart disease is a medicament made of the following traditional Chinese medicine raw materials in the following weight ratio: Panax notoginseng 15, Salvia miltiorrhiza 10, Rhodiola rosea 15, Chenpi 15, Hawthorn 25 , white chrysanthemum 25.

[0047] Further, the preparation method of each raw material extract is as follows:

[0048] Radix Notoginseng Extract: Dry and crush Radix Notoginseng, extract in stages with industrial ethanol, filter and combine the filtrate, distill the filtrate to a certain amount under reduced pressure, add water and continue to distill until there is no alcohol smell, and then adjust to 1ml of medicinal liquid with water Equivalent to 1g of crude drug, pass the liquid through D 101 Macroporous adsorption resin column and elute with 50% ethanol, filter and cool, let the filtrate pass through a funnel covered with a small amount of neutral alumina, recover e...

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Abstract

The invention discloses an oral preparation for preventing coronary heart disease, which is prepared by the steps of extracting traditional Chinese medicine raw materials, including radix notoginseng,radix salviae milti orrhizae, herba rhodiolae sacrae, pericarpium citri reticulatae, fructus crataegi and flos chrysanthemi, preparing pharmaceutical composition powder from the extract, and finallypreparing the oral preparation from the pharmaceutical composition powder with propylene glycol as a solvent and phospholipid complex as absorption promoter. The oral preparation has the advantages that transmembrane transport of Panax Notoginseng Saponins, salvia acid B and salidroside is improved greatly, degradation of the oral preparation in gastrointestinal tract is reduced, and further oralabsorption of drug is improved; the oral preparation has functions such as tonifying qi and yin, promoting blood circulation to remove blood stasis, warming yang and dredging channels, clearing internal heat and facilitating bowel movement, and can improve physical health and delay senescence after long-term use; capsules and enteric capsules prepared from the oral preparation can be taken directly, without being decocted.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to an oral preparation for preventing coronary heart disease. Background technique [0002] Coronary heart disease is the abbreviation of coronary atherosclerotic heart disease. The coronary arteries supply the heart's own blood. Severe atherosclerosis or spasm occurs in the coronary arteries, which narrows or occludes the coronary arteries, leading to myocardial ischemia, hypoxia, or infarction. sick. The main clinical manifestations are angina pectoris and arrhythmia caused by myocardial ischemia and hypoxia. In severe cases, myocardial infarction may occur, resulting in extensive myocardial necrosis and life-threatening. [0003] At present, the clinical effect of treating coronary heart disease is not very satisfactory, so people pay more and more attention to the prevention of coronary heart disease. Among them, traditional Chinese medicine has the advantages of good curativ...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P9/10
CPCA61K36/258A61K36/287A61K36/41A61K36/537A61K36/734A61K36/752A61K2236/33A61K2236/331A61K2236/333A61P9/10A61K2300/00
Inventor 张登沈王峰万晶梁贵友刘达兴
Owner AFFILIATED HOSPITAL OF ZUNYI MEDICAL COLLEGE
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