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Joint cavity injection for treating osteonecrosis

A joint cavity and injection technology, which is applied in the field of biomedicine and can solve problems such as excessively high effective doses

Inactive Publication Date: 2018-12-25
申意伟 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

BMP homodimers (such as BMP2, BMP7) have not been widely used clinically due to their high effective dosage

Method used

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  • Joint cavity injection for treating osteonecrosis

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Experimental program
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Effect test

Embodiment 1

[0016] A joint cavity injection for the treatment of osteonecrosis, sodium hyaluronate 0.65mg, graphene quantum dots 110μg, BMP2 / 7 heterodimer 20ng, sodium chloride 1g, add sterilized water for injection to 100mL, adjust the pH value 7.35 (hydrochloric acid / sodium hydroxide titration).

[0017] Usage: 3mL / time (when nuclear magnetic resonance shows a large amount of joint effusion, the amount can be appropriately reduced), 1 time / week, local skin disinfection, intra-articular injection, joint activities without weight bearing after injection for 20-30min. It is suitable for patients with osteonecrosis and arthritis with mild to moderate pain.

Embodiment 2

[0019] Sodium hyaluronate 0.65mg, graphene quantum dots 110μg, BMP2 / 7 heterodimer 20ng, sodium chloride 0.95g, lidocaine 1g, add sterile water for injection to 100mL, adjust the pH value to 6.35 (hydrochloric acid / hydrogen Sodium oxide titration).

[0020] Usage: 3mL / time (when nuclear magnetic resonance shows a large amount of joint effusion, the amount can be appropriately reduced), 1 time / week, local skin disinfection, intra-articular injection, joint activities without weight bearing after injection for 20-30min. It is suitable for patients with osteonecrosis and severe arthritis pain. Lidocaine is a very good local anesthetic. It takes effect within one to three minutes of application and lasts for one to three hours. Because lidocaine hydrochloride is a white crystalline powder, it is easily soluble in water, and its toxicity is equivalent to that of procaine, but its local anesthetic effect is strong and long-lasting, and it has good surface penetration. It can be inje...

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Abstract

The invention discloses joint cavity injection for treating osteonecrosis, and belongs to the field of biomedicine. Sodium hyaluronate, graphene quantum dots and BMP (bone morphogenetic protein) 2 / 7 heterodimers are mixed with one another according to certain quantities to obtain the joint cavity injection. The joint cavity injection has the advantages that the joint cavity injection can directlyreach affected parts when administrated by means of injection, accordingly, pathological joint fluid can be improved, lubrication functions can be increased, the osteogenic activity of mesenchymal stem cells can be excited, osteogenesis of osteoblasts can be promoted, osteolysis of osteoclasts can be inhibited, osteonecrosis repair can be promoted, and functions of joints can be reserved; the joint cavity injection is used for treating osteonecrosis related diseases related to the joints.

Description

technical field [0001] The invention belongs to the field of biomedicine, in particular to a joint cavity injection for treating osteonecrosis. Background technique [0002] In the course of joint degeneration, it is often accompanied by the pathological process of osteonecrosis. Osteonecrosis refers to the necrosis of the living tissue components of the human skeleton. In traditional Chinese medicine, osteonecrosis is referred to as bone erosion. In many parts of the human body, more than 40 places have been found in avascular necrosis alone. Clinical studies have confirmed that those who are positive for hip and knee joint osteonecrosis, regardless of whether other joints have clinical symptoms, have the risk of multifocal osteonecrosis in one to several joints of the shoulder, ankle, wrist, and elbow. 80% of patients with femoral head necrosis will have femoral head collapse and osteoarthritis within 4 years. Statistics from the World Health Organization show that the n...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61K9/08A61P19/08A61P29/00A61K33/44A61K31/728A61K31/167
CPCA61K9/0019A61K9/08A61K31/167A61K31/728A61K33/44A61K38/1875A61P19/08A61P29/00
Inventor 不公告发明人
Owner 申意伟
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