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A kind of in-situ coating modified bacterial cellulose hydrogel and preparation method thereof

A technology of bacterial cellulose and hydrogel, applied in the direction of biochemical equipment and methods, coatings, methods based on microorganisms, etc., can solve the problems of difficult control, time and energy consumption, cumbersome process, etc., and achieve the effect of simple process

Active Publication Date: 2020-07-10
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention provides a method for in-situ coating modification of bacterial cellulose hydrogel, aiming at the problems of cumbersome process, time-consuming and energy-consuming, difficult to control and other problems of the existing bacterial cellulose hydrogel functional modification method

Method used

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  • A kind of in-situ coating modified bacterial cellulose hydrogel and preparation method thereof
  • A kind of in-situ coating modified bacterial cellulose hydrogel and preparation method thereof
  • A kind of in-situ coating modified bacterial cellulose hydrogel and preparation method thereof

Examples

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Embodiment 1

[0031] Example 1: Preparation of Bacterial Cellulose Hydrogel Modified by Chitosan Coating

[0032] The preparation process is like image 3 As shown, it contains the following steps:

[0033] (1) Prepare standard HS culture solution: Weigh 4g glucose, 1g yeast powder, 0.54g disodium hydrogen phosphate, 0.23g citric acid and dissolve in ultrapure water to prepare 200mL standard HS culture solution;

[0034] (2) Add 2g of chitosan (molecular weight: about 100,000) to the standard HS culture solution, stir it thoroughly, and after dispersing and mixing, use autoclave sterilization to make the chitosan turn brown.

[0035] (3) Inoculate 5 mL of Acetobacter xylinum (American Standard Library ATCC 53582) into the standard HS culture solution containing chitosan described in step (1), and cultivate in a constant temperature incubator at 30°C for 10 days to obtain chitosan The bacterial cellulose hydrogel modified by sugar coating shows a two-layer structure, in which the upper layer (that ...

Embodiment 2

[0040] Example 2: Preparation of Bacterial Cellulose Hydrogel Modified by Chitosan Coating

[0041] Based on Example 1, the difference is: the amount of chitosan in step (2) is changed to 4g, the culture time in step (3) is changed to 15 days, and the rest are the same as in Example 1.

Embodiment 3

[0042] Example 3: Preparation of Bacterial Cellulose Hydrogel Modified by Chitosan Coating

[0043] Based on Example 1, the difference is: the amount of chitosan in step (2) is changed to 6 g, and the culture time in step (3) is changed to 5 days, and the rest are the same as in Example 1.

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Abstract

The invention relates to in-situ coating-modified bacterial cellulose hydrogel and a method for preparing the same, and belongs to the technical field of biological materials. The in-situ coating-modified bacterial cellulose hydrogel comprises bacterial cellulose layers and modified layers. The corresponding modified layers are modified on at least one surface of each bacterial cellulose layer andare water-insoluble biological macromolecule layers; the water-insoluble biological macromolecule layers are connected with the bacterial cellulose layers by physical adsorption and interaction forceof hydrogen bonds. Water-insoluble biological macromolecules are added into culture solution, and bacterial cellulose hydrogel with a single modified surface can be obtained by means of bacterial fermentation; the bacterial cellulose hydrogel with the single modified surface can be taken out and can be placed on gas-solution interfaces of the culture solution upside down to continue being subjected to culture, so that bacterial cellulose hydrogel with double modified surfaces can be obtained. The in-situ coating-modified bacterial cellulose hydrogel and the method have the advantages that thesurfaces of the bacterial cellulose hydrogel can be modified while the bacterial cellulose hydrogel is synthesized by the aid of in-situ coating modification processes, complicated chemical procedures can be omitted, organic solvents or professional preparation equipment are not required, accordingly, energy can be saved, environments can be protected, and the in-situ coating-modified bacterial cellulose hydrogel and the method are simple and convenient and are high in efficiency.

Description

Technical field [0001] The invention belongs to the field of biological materials, and specifically relates to a method for in-situ coating to modify bacterial cellulose hydrogel. Background technique [0002] Bacterial cellulose (BC) refers to cellulose synthesized by microorganisms such as Acetobacter xylinum. Its hydrogel has fine network structure, high mechanical strength, high water content, good biocompatibility and biodegradability, etc. Features. Therefore, as an excellent matrix material, it is widely used in the construction of functional materials and devices such as biomedicine and optoelectronics. Among them, how to functionally modify the bacterial cellulose hydrogel is the key. [0003] At present, the surface functional modification of bacterial cellulose hydrogel mainly includes physical doping and chemical modification. For example, Shi Zhijun et al. used the method of physical doping to penetrate polyaniline into the bacterial cellulose hydrogel to obtain a co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/04C08J3/075C08L1/02C12P19/04C12R1/01C12R1/41
CPCC08J3/075C08J7/0427C08J2301/02C08J2405/00C08J2489/00C12P19/04
Inventor 杨光肖林黄丽霞付丽娜刘莉
Owner HUAZHONG UNIV OF SCI & TECH