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Preparation method of alpha-GPC

A technology of sodium tert-butoxide and tert-butanol, which is applied in the field of preparation of α-GPC, can solve the problems of low yield, achieve high catalytic activity, achieve homogeneous catalysis, and increase the effect of carrying capacity

Inactive Publication Date: 2019-01-04
湖南中茂生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But the productive rate of the method for producing GPC at present is all relatively low, urgently needs a kind of production method that can improve GPC productive rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A preparation method of α-GPC, comprising the following steps:

[0023] S1. Weigh 2g of phospholipids and dissolve in 100mL of tert-butanol;

[0024] S2. Add configured 15mL sodium tert-butoxide-tert-butanol solution in step S1;

[0025] S3. Place the solution configured in step S2 on a reflux device, and condense and reflux for 5 hours;

[0026] S4. Evaporate the solution obtained in step S3 to dryness in vacuo, then add 20 mL of petroleum ether, remove the supernatant, and hollow-dry the bottom.

[0027] Further, the configuration method of sodium tert-butoxide-tert-butanol includes: weighing 0.5-1 g of sodium tert-butoxide into 50 mL of tert-butanol solution, stirring and dissolving; again weighing 0.5-1 g of sodium tert-butoxide and placing In the tert-butanol solution, stir to dissolve, and stop when insoluble matter exists in the tert-butanol solution after repeated repetitions.

[0028] Further, the sodium tert-butoxide added in step S2 is sodium tert-butoxide...

Embodiment 2

[0032] A preparation method of α-GPC, comprising the following steps:

[0033] S1. Weigh 3g of phospholipids and dissolve in 150mL of tert-butanol;

[0034] S2. Add the configured 20mL sodium tert-butoxide-tert-butanol solution in step S1;

[0035] S3. Place the solution configured in step S2 on a reflux device, and condense and reflux for 6 hours;

[0036] S4. Evaporate the solution obtained in step S3 to dryness in vacuo, then add 25 mL of petroleum ether, remove the supernatant, and hollow-dry the bottom.

[0037] Further, the configuration method of sodium tert-butoxide-tert-butanol includes: weighing 0.5-1 g of sodium tert-butoxide into 50 mL of tert-butanol solution, stirring and dissolving; again weighing 0.5-1 g of sodium tert-butoxide and placing In the tert-butanol solution, stir to dissolve, and stop when insoluble matter exists in the tert-butanol solution after repeated repetitions.

[0038] Further, the sodium tert-butoxide added in step S2 is sodium tert-buto...

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Abstract

The invention relates to the field of organic synthesis, in particular to a preparation method of alpha-GPC. The method includes the steps of S1, weighing 2-3g of phospholipid, and dissolving into 100-150mL of tertiary butanol; S2, adding a 15-20mL of prepared sodium tert-butoxide-tertiary butanol solution into the solution obtained in S1; S3, placing the solution obtained in S2 on a reflux device, and performing condensation reflux for 5-6 hours; S4, performing vacuum distillation drying on the solution obtained in S3, adding 20-25mL of petroleum ether, removing supernate, and performing vacuum drying on the precipitate. The method has the advantages that tertiary butanol has three methyl, the methyl is electrode pushing groups and can increase the activity of hydroxyl, and the formed sodium tert-butoxide has high catalytic activity and can well promote phospholipid hydrolysis to form the alpha-GPC; the sodium tert-butoxide is compounded by using a metal organic frame structure, and the metal organic frame structure has an adjustable gap structure and can increase the carrying capacity of the sodium tert-butoxide; in addition, the metal organic frame structure Fe-MIL-101 has goodsolubility in the tertiary butanol and can well achieve homogeneous catalysis to promote the catalytic reaction.

Description

technical field [0001] The invention relates to the field of organic synthesis, in particular to a preparation method of α-GPC. technical background [0002] α-Glycerophosphatidylcholine, abbreviated as α-GPC or GPC, is a water-soluble metabolite naturally occurring in humans and animals, and is the product of the complete hydrolysis of two fatty acid chains on the phospholipid (PC) molecule. Pure GPC is transparent viscous or white powder, easy to absorb moisture in the air, highly soluble in water or methyl ethanol, almost insoluble in other solvents. GPC can be used as a choline supplement, which can stimulate the secretion of growth hormone in young people, and has a positive effect on memory ability, concentration and cognitive ability. [0003] GPC is a unique water-soluble phospholipid that naturally exists in the human body. It has important application value in the pharmaceutical and food industries. Especially in the health food boom in recent years, GPC has shown...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/09
CPCC07F9/091
Inventor 赵勇彪李佳莲易娜何鹏
Owner 湖南中茂生物科技有限公司
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