A kind of bursa active hexapeptide for promoting the immune response of bird flu and/or Newcastle disease vaccine and its application

A technology of bursal polypeptide and bursa, which is applied in the direction of chemical instruments and methods, medical preparations containing active ingredients, peptides, etc., can solve the problems of strengthening the stress response of chickens and consuming a lot of manpower and material resources, and achieve improvement The ability to resist epidemic infection, the improvement of antigen presentation response, and the effect of improving immune efficacy
CN109180784BActive Publication Date: 2019-10-11NANJING AGRICULTURAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING AGRICULTURAL UNIVERSITY
Publication Date
2019-10-11

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Abstract

The invention relates to isolation, identification and application of a Fabricius bursa active hexapeptide for promoting an immunoreaction of avian influenza and / or a Newcastle disease bivalent vaccine. The Fabricius bursa active hexapeptide has an amino acid composition of Lys Gly Asn Arg Val Tyr, has a simple structure and is extremely weak in immunogenicity. The active peptide has the functionof promoting the immune response of the vaccine and can promote the antibody reaction against the AIV antigen and the antibody reaction against the NDV antigen in the mouse in the mouse immunization experiment. The active peptide can promote the cellular immune response, improve lymphocyte viability and an antigen presentation reaction and improve the vaccine immunopotency, can be used as a vaccine adjuvant or immunopotentiator in animal vaccine application research, can improve the immune response of animal organisms to specific antigens, can improve the immune efficacy of vaccines and can improve the ability of animal organisms resisting epidemic disease infection.
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Description

technical field

[0001] The invention belongs to the technical field of veterinary biological products, and in particular relates to a bursa active hexapeptide capable of promoting the immune response of the vaccine avian influenza and / or the dual vaccine with Newcastle disease and its application. Background technique

[0002] Avian influenza (Avian influenza, AI) is an infection or disease syndrome caused by avian influenza virus (Avian influenza virus, AIV). After poultry are infected with AIV, some do not show clinical symptoms, and some show a decrease in egg production. And respiratory diseases, and even lead to systemic diseases, the mortality rate can reach 100%. Therefore, avian influenza can be divided into low pathogenic avian influenza (LPAI) and highly pathogenic avian influenza (HPAI) according to the degree of pathogenicity. H9N2 subtype avian influenza virus is one of the most widespread low-pathogenic avian influenza viruses in the world. Its impact on poult...

Claims

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