6 results about "Immunization program" patented technology

The invention discloses an immune planning visual monitoring method and device, electronic equipment and a storage medium, and relates to the technical field of immune monitoring. The method comprises the steps that a first instruction is received, and a first display interface containing a multi-modal data set is generated; performing synchronous prediction on the multi-modal data set to obtain inventory gap probability distribution and expiration risk distribution, and displaying a corresponding visual layer in a first display interface; when any distribution meets a preset early warning condition, popping up an interpretable early warning card in the first display interface; and after binding the early warning vector corresponding to the interpretable early warning card with the current outpatient service identifier, displaying an early warning event record in a rolling manner in a time axis form in a first display interface. In this way, the problems that in the prior art, the service data clock granularity is different, early warning only stays in static characters, risk reasons cannot be explained, manual screenshot is needed in post-event auditing, and evidences are prone to being tampered can be solved.

Provided are a Trichinella spiralis vaccine kit based on a prime-boost sequential immunization program and use thereof, improving the protective effect against trichinosis. The kit is divided into two parts; the first part is a Trichinella spiralis recombinant protein vaccine having an amino acid sequence set forth in SEQ ID NO. 1 or SEQ ID NO. 2, and the second part is a recombinant adenovirus expressing an amino acid sequence set forth in SEQ ID NO. 1. The prime-boost immunization strategy not only effectively avoids the deficiency associated with a single-type Trichinella spiralis vaccine, but also significantly improves the efficacy and durability of the immune response.

The invention discloses a method for preparing a high-titer polyclonal antibody from a Zika virus strain, which comprises the following steps: selecting the Zika virus strain, culturing in cells, and purifying virus particles with high purity to prepare an immunogen; an optimized animal immunization strategy is adopted and comprises the steps of selecting a proper host animal, applying a potent immunologic adjuvant, namely a Freund's adjuvant, and designing a scientific immunization program, so that humoral immune response of the host is stimulated to the maximum extent; when the titer of the antibody reaches a peak value, collecting antiserum, synthesizing hybridoma cells through splenocytes, and obtaining the high-purity polyclonal antibody through a multi-step purification technology. According to the method, high-purity and non-chemically-inactivated whole virus particles which retain natural conformation are used as immunogens, a mode of primary immunization and multiple booster immunization is adopted, a Freund's adjuvant is combined, animals are continuously stimulated to generate high-titer antibodies, non-specific antibodies and impurities are effectively removed through multi-step purification, and the immunogen immunogen is obtained. The target antibody with high purity and high specificity is obtained.

Provided are a rabies virus G protein mutant, a preparation method and application thereof, and relate to the technical field of biological medicine. The rabies virus G protein mutant is obtained by point mutation on the extracellular domain of the G protein. The mutant realizes soluble expression of the extracellular domain of the G protein, and can induce production of high-titer neutralizing antibodies. Compared with commercial human rabies vaccine and canine rabies vaccine, the mutant has more excellent cellular immune and antibody immune responses, and is expected to reduce the number of inoculations, shorten the immunization program and reduce the immunization dose.

The application provides a kind of preventive inoculation information quick entry and check device, relating to medical information technology field, including information collection registration module, database storage module, central check processing module, interactive alarm module and inoculation execution confirmation module;The application obtains the identity of the recipient and vaccine information through multi-modal mode, and encapsulates into standardized data packet, avoids the problem of low efficiency of manual entry, then the central check processing module carries out real-time, multi-dimensional logical reasoning calculation based on dynamic rules, and the back-end operation and management indexes such as cold chain quality and inventory status are preposed as real-time check dimensions as important as medical contraindications and immunization programs, so that the use of invalid vaccine, inventory shortage misregistration and other difficult to prevent risks are actively intercepted before inoculation occurs, and further, the man-machine collaborative decision mechanism of alarm state is introduced, which ensures that the safety bottom line is not broken, and gives the final decision-making right to medical staff in complex situation.

The invention discloses an immune planning information intelligent query decision-making method and system based on domain knowledge, and the method comprises the following steps: S1, obtaining a plurality of immune planning knowledge maps, traversing the immune planning knowledge maps, and extracting a multi-hop path; relates to the technical field of preventive vaccination information query, and solves the problem of incomplete entity association of a single knowledge graph by acquiring a plurality of immune planning knowledge graphs and extracting a multi-hop path; a completion query vector is generated by checking the entity identifier adaptability of a term mapping table and a knowledge base, so that the problem of conversion between spoken language expression and technical terms and the problem of recognition and completion of missing entities in query data are solved; according to the method, the query instruction containing the entity pair weight is generated based on the adapted term mapping table and the knowledge base multi-hop path, the query result is screened through the path comprehensive priority score, and the method is different from traditional retrieval only depending on keyword matching, so that the accuracy of immune planning information query decision is improved.