12 results about "Immunization program" patented technology

The invention discloses a quadruple mRNA vaccine for preventing feline infectious diseases and application thereof, the quadruple mRNA vaccine can simultaneously prevent feline rabies, feline calicivirus disease, feline panleucopenia and feline rhinotracheitis through one-time immunization, and experiments show that the vaccine is relatively safe and strong in efficacy, the injection cost is reduced, and the vaccine is suitable for clinical application. The immune procedure is optimized, and the method has great significance in preventing cat infectious diseases.

The invention discloses an immune planning visual monitoring method and device, electronic equipment and a storage medium, and relates to the technical field of immune monitoring. The method comprises the steps that a first instruction is received, and a first display interface containing a multi-modal data set is generated; performing synchronous prediction on the multi-modal data set to obtain inventory gap probability distribution and expiration risk distribution, and displaying a corresponding visual layer in a first display interface; when any distribution meets a preset early warning condition, popping up an interpretable early warning card in the first display interface; and after binding the early warning vector corresponding to the interpretable early warning card with the current outpatient service identifier, displaying an early warning event record in a rolling manner in a time axis form in a first display interface. In this way, the problems that in the prior art, the service data clock granularity is different, early warning only stays in static characters, risk reasons cannot be explained, manual screenshot is needed in post-event auditing, and evidences are prone to being tampered can be solved.

The invention discloses a trichina vaccine kit based on a Prime-boost sequential immune procedure and application of the trichina vaccine kit, and belongs to the technical field of genetic engineering. The invention aims to improve the protection effect of trichinosis. The invention provides a trichina vaccine kit, the kit is divided into two parts, the first part is a trichina recombinant protein vaccine with an amino acid sequence as shown in SEQ ID NO.1 or SEQ ID NO.2, and the second part is recombinant adenovirus with an expression amino acid sequence as shown in SEQ ID NO.1. The Prime-boost immune strategy not only effectively avoids the deficiency of a single type of trichina vaccine, but also significantly improves the efficacy and durability of immune response, and provides more efficient and comprehensive immune protection for the organism.

Provided are a Trichinella spiralis vaccine kit based on a prime-boost sequential immunization program and use thereof, improving the protective effect against trichinosis. The kit is divided into two parts; the first part is a Trichinella spiralis recombinant protein vaccine having an amino acid sequence set forth in SEQ ID NO. 1 or SEQ ID NO. 2, and the second part is a recombinant adenovirus expressing an amino acid sequence set forth in SEQ ID NO. 1. The prime-boost immunization strategy not only effectively avoids the deficiency associated with a single-type Trichinella spiralis vaccine, but also significantly improves the efficacy and durability of the immune response.

The invention discloses a method for preparing a high-titer polyclonal antibody from a Zika virus strain, which comprises the following steps: selecting the Zika virus strain, culturing in cells, and purifying virus particles with high purity to prepare an immunogen; an optimized animal immunization strategy is adopted and comprises the steps of selecting a proper host animal, applying a potent immunologic adjuvant, namely a Freund's adjuvant, and designing a scientific immunization program, so that humoral immune response of the host is stimulated to the maximum extent; when the titer of the antibody reaches a peak value, collecting antiserum, synthesizing hybridoma cells through splenocytes, and obtaining the high-purity polyclonal antibody through a multi-step purification technology. According to the method, high-purity and non-chemically-inactivated whole virus particles which retain natural conformation are used as immunogens, a mode of primary immunization and multiple booster immunization is adopted, a Freund's adjuvant is combined, animals are continuously stimulated to generate high-titer antibodies, non-specific antibodies and impurities are effectively removed through multi-step purification, and the immunogen immunogen is obtained. The target antibody with high purity and high specificity is obtained.

The invention discloses a porcine pseudorabies GE purification scheme, and the purification method comprises the following steps: S1, pig farm environment background evaluation and odor purification device installation; s2, evaluating the health status of the swinery and optimizing an immune program; s3, epidemic disease purification and odor cooperative control; s4, environment-epidemic disease linkage monitoring and early warning are carried out; and S5, maintaining the purification effect. The environment stress is reduced through the odor purification device, the immunity of pigs is enhanced, and the propagation opportunity of PRV is reduced; biodegradation and photocatalysis technologies are combined, so that a remarkable inactivation effect on PRV aerosol is achieved; establishing a first machine learning-based environment parameter and PRV propagation risk prediction model to realize early warning; the use amount of disinfectants is reduced by 40%, the use amount of antibiotics is reduced, and green breeding is achieved; the PRV purification period can be shortened, the maintenance cost is reduced, and meanwhile, the working environment of a pig farm is remarkably improved.

Provided are a rabies virus G protein mutant, a preparation method and application thereof, and relate to the technical field of biological medicine. The rabies virus G protein mutant is obtained by point mutation on the extracellular domain of the G protein. The mutant realizes soluble expression of the extracellular domain of the G protein, and can induce production of high-titer neutralizing antibodies. Compared with commercial human rabies vaccine and canine rabies vaccine, the mutant has more excellent cellular immune and antibody immune responses, and is expected to reduce the number of inoculations, shorten the immunization program and reduce the immunization dose.

The invention relates to a validity period dynamic monitoring and early warning system suitable for immune planning vaccines, and the system comprises data acquisition modules which are in communication connection with each other and are used for acquiring vaccine basic data including vaccine serial numbers, validity periods, real-time inventory quantity and predicted consumption rate; the residual effective period calculation module is used for calculating the residual effective period based on the effective period; the available duration calculation module is used for calculating the available duration of the vaccine based on the real-time inventory quantity and the predicted consumption rate; the risk quantification module is used for calculating an early warning coefficient based on the vaccine sequence number, the residual effective period and the available duration; and the early warning generation module is used for generating a plurality of grading early warning signals based on the early warning coefficient, outputting inventory adjustment strategies corresponding to the plurality of grading early warning signals, and carrying out overall processing on inventory vaccines so as to reduce the risk of'shortage 'or'waste' of the vaccines.

The invention relates to a vaccine efficient combined immunization method for reducing stress of breeding hens, belongs to the technical field of animal epidemic prevention, and mainly solves the problems of multiple kinds of epidemic diseases needing to be prevented, multiple kinds of vaccination, multiple inoculation and injection times, high stress, inaccurate injection dosage, poor immunization effect and the like in breeding of the breeding hens. The invention provides a set of inactivated vaccine mixing device. According to the invention, an assembled inactivated vaccine mixing device is applied, and on the basis of a breeder's original immunization plan and injection vaccination vaccine types, by changing the vaccination mode, one-time injection and vaccination of various vaccines are realized; the total number of times of injection and inoculation in the whole feeding period is reduced, however, the number of times of single epidemic disease vaccine stimulation is large, inoculation stress is reduced, the inoculation dosage is more accurate, the response capacity of chickens to vaccines is improved, the antibody titer after immunization is high, the protection rate is high, meanwhile, the vaccine immunization workload is reduced, and the breeding chicken feeding benefits are improved. The method is mainly used for preventive inoculation of inactivated vaccines for avian influenza, Newcastle disease, infectious bursal disease, mycoplasmosis, infectious bronchitis, infectious rhinitis, egg drop syndrome and other epidemic diseases of breeding hens, and can also be popularized to immunization of other animal inactivated vaccines.

The invention relates to the technical field of vaccine preparation, in particular to a bivalent subunit vaccine based on rabbit hemorrhagic disease virus type 2 VLPs and pasteurella multocida OMV as well as a preparation method and application of the bivalent subunit vaccine based on the rabbit hemorrhagic disease virus type 2 VLPs and the pasteurella multocida OMV. The vaccine is obtained by combining type 2 rabbit hemorrhagic disease virus VLPs and pasteurella multocida OMV; the mass ratio of the type 2 rabbit hemorrhagic disease virus VLPs to the pasteurella multocida OMV is 1: 1 or 1: 2. The invention aims to construct a novel bivalent vaccine capable of preventing RHDV2 and Pm infection at the same time. Establishing a preparation process of VLPs of RHDV2 and OMV of Pm, and efficiently combining the VLPs and the OMV to form a bivalent subunit vaccine; the optimal immune dose and the scientific immune procedure are defined by performing immune test and challenge protection effect evaluation on the domestic rabbits. The research aims at providing a scientific basis for developing the RHDV2 and rabbit Pm bigeminy subunit vaccine, has industrial development potential and has important significance on high-quality development of the special rabbit industry.

The application provides a kind of preventive inoculation information quick entry and check device, relating to medical information technology field, including information collection registration module, database storage module, central check processing module, interactive alarm module and inoculation execution confirmation module;The application obtains the identity of the recipient and vaccine information through multi-modal mode, and encapsulates into standardized data packet, avoids the problem of low efficiency of manual entry, then the central check processing module carries out real-time, multi-dimensional logical reasoning calculation based on dynamic rules, and the back-end operation and management indexes such as cold chain quality and inventory status are preposed as real-time check dimensions as important as medical contraindications and immunization programs, so that the use of invalid vaccine, inventory shortage misregistration and other difficult to prevent risks are actively intercepted before inoculation occurs, and further, the man-machine collaborative decision mechanism of alarm state is introduced, which ensures that the safety bottom line is not broken, and gives the final decision-making right to medical staff in complex situation.

The invention discloses an immune planning information intelligent query decision-making method and system based on domain knowledge, and the method comprises the following steps: S1, obtaining a plurality of immune planning knowledge maps, traversing the immune planning knowledge maps, and extracting a multi-hop path; relates to the technical field of preventive vaccination information query, and solves the problem of incomplete entity association of a single knowledge graph by acquiring a plurality of immune planning knowledge graphs and extracting a multi-hop path; a completion query vector is generated by checking the entity identifier adaptability of a term mapping table and a knowledge base, so that the problem of conversion between spoken language expression and technical terms and the problem of recognition and completion of missing entities in query data are solved; according to the method, the query instruction containing the entity pair weight is generated based on the adapted term mapping table and the knowledge base multi-hop path, the query result is screened through the path comprehensive priority score, and the method is different from traditional retrieval only depending on keyword matching, so that the accuracy of immune planning information query decision is improved.