A lysosome-targeted pH-sensitive nanoparticle and its preparation method and application
A nanoparticle and lysosome technology, applied in the field of biomedicine, can solve the problems of poor tumor chemotherapy effect, low effective drug loading, and low-efficiency aggregation of nanoparticles, so as to improve the degree of aggregation and effective drug loading, and improve The effect of lethality and optimal tumor chemotherapy effect
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[0036] The following is further described in detail through specific implementation methods:
[0037] One, the preparation method of the lysosome-targeted pH-sensitive nanoparticles of the present invention, the specific steps are as follows:
[0038] (1) Preparation of silk protein liquid
[0039] Put the cocoon in Na 2 CO 3 Boil in sodium carbonate (0.02M) solution for 1h, then replace with fresh Na 2 CO 3 The solution was boiled again for 1 hour, and then the silkworm cocoons were soaked in deionized water, and the water was changed 4-5 times in the middle to wash off the sericin protein on the surface of the silkworm cocoon; then the degummed silk protein was dissolved in LiBr (9.2M) solution of lithium bromide at 60°C After 5 hours, transfer to deionized water and dialyze for 3 days to remove impurities and other ions, and finally filter and collect the silk protein liquid, freeze-dry for later use;
[0040] (2) Preparation of nanoparticles
[0041] Dissolve 5 mg of d...
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