27results about How to "Good clinical applicability" patented technology

The invention discloses a detection method of a systemic lupus erythematosus immune spectrum based on full spectrum flow cytometry, and relates to the technical field of cell detection, and the detection method comprises the following steps: providing a fluorescein coupling antibody of a detection index; carrying out antibody titration on the fluorescein coupling antibody to obtain a dyeing concentration; the method comprises the following steps: carrying out surface staining on peripheral blood mononuclear cells of an SLE patient by adopting a fluorescein coupled antibody, carrying out intracellular mitochondrial superoxide staining, and resuspending in a detection solution to obtain a test sample; carrying out sample loading test on the test sample and the prepared single staining reference sample and negative sample, and collecting and analyzing particle information; and performing enclosure and dimension reduction analysis on the analyzed data to obtain a systemic lupus erythematosus immune spectrum and a cell activation state analysis result. According to the application, dozens of immune cell subtypes and activation states thereof in SLE can be detected under the condition of a single-tube sample, an SLE patient immune map is constructed, and a reference is provided for evaluating disease progression and formulating a treatment scheme.

The invention relates to the technical field of NK cell culture, and discloses a serum-free medium for NK cells from umbilical cord blood after cryopreservation and a culture method thereof.The medium comprises a coating solution, an induction medium and an amplification medium; wherein the coating liquid is prepared from an anti-CD16 monoclonal antibody and DPBS (diphenylphosphonic acid); the induction culture medium comprises a basic culture medium, a human-derived platelet lysate and cell factors IL-15, IL-18 and IL-21; the amplification culture medium comprises a basic culture medium, a human-derived platelet lysate and IL-2. The culture method comprises the following steps: obtaining mononuclear cells from fresh umbilical cord blood, and then cryopreserving and resuscitating; and carrying out multiplication culture on the recovered umbilical cord blood mononuclear cells by using the serum-free culture medium. According to the NK cell culture medium, the NK cells with high purity, high killing activity and high cytotoxic activity can be obtained without autoserum culture.

The invention provides a breast cancer grading analysis system and method based on artificial intelligence, a terminal and a medium. The system comprises an ultrasonic image module, a molybdenum target image module and a clinical information module. The ultrasonic image module and the molybdenum target image module can be used independently or in a combined mode. The independent use of the ultrasonic image module can be deployed in the ultrasonic department for use, and the independent use of the molybdenum target image module can be deployed in the radiology department for use, and is suitable for scenes with partial image missing. The mixing module (mixed with the clinical information module or without the clinical information module) can be deployed for use in breast surgery. Under the condition of independent use or mixed use, the system can output two decisions, namely a fine-level pathological layer and a Coarse-level image BI-RADS layer. The method has the technical effects of being high in generalization ability, high in modularization and clinical adaptability, high in accuracy, high in interpretability, high in grading decision-making ability and the like.

The application discloses a medical inquiry logic chain generation and verification method and system based on a large language model, relates to the technical field of artificial intelligence, and comprises the following steps: S1, generating a logic chain framework, constructing a medical inquiry logic chain generation model, and embedding a structured logic template and professional knowledge constraints in a large language model as a core engine; S2, designing a two-dimension multi-level verification framework to automatically check the consistency and medical rationality of the generated corpus logic chain; and S3, designing an evaluation index system and a dynamic optimization strategy, grading and marking the problem corpus identified in the verification, and performing corresponding correction, so that the correction result is fed back to the model training link to optimize the logic chain generation rule. Through NLP technology, a language model generation mechanism, medical knowledge structure analysis and an intelligent verification algorithm, the quality, the degree of structuring and the application value of the medical inquiry data set in an intelligent inquiry system are improved, and high-quality and controllable professional corpus support is provided.

The invention discloses a traditional Chinese medicine composition for treating delayed absorption of qi-yin deficiency and lung collateral obstruction type pneumonia, a preparation and application. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 10 to 15g of radix pseudostellariae, 10 to 15g of radix asparagi, 6 to 10g of cortex mori radicis, 6 to 10g of radix scutellariae, 6 to 10g of radix platycodonis, 6 to 10g of exocarpium citri grandis, 6 to 10g of bulbus fritillariae thunbergii, 10 to 15g of pericarpium trichosanthis, 10 to 15g of spica prunellae, 15 to 30g of raw oyster shell, 6 to 10g of earthworm, 10 to 15g of radix salviae miltiorrhizae, 6 to 10g of rhizoma curcumae and 6 to 10g of raw liquorice root. The traditional Chinese medicine composition is suitable for delayed absorption of pneumonia caused by deficiency of both qi and yin and obstruction of lung collaterals, and also can be used for treating deficiency-heat syndrome and deficiency-cold syndrome on the basis of the formula, so that the aim of treating due to symptoms is fulfilled. The prescription is used for treating both symptoms and root causes of patients with deficiency of both qi and yin, internal stagnation of phlegm and blood stasis and lung collateral obstruction in delayed absorption of pneumonia on the basis of the basic treatment principles of tonifying lung and yin, reducing phlegm and softening hard mass, and promoting blood circulation to remove meridian obstruction. Clinical research finds that the pharmaceutical composition can improve clinical symptoms of patients with delayed absorption of pneumonia and promote inflammatory absorption, and is relatively safe.

The preparation process of the eczema cream comprises the following steps: S1, raw material pretreatment: coarsely crushing calcined calamine; removing impurities from cortex phellodendri, coarsely crushing, and removing impurities from indigo naturalis for later use; mixing the three components, performing superfine grinding, and sieving with a 100-mesh sieve to obtain a medicinal powder raw material; s2, substrate preparation: melting and stirring beeswax and sesame oil at 85-90 DEG C, and cooling to obtain a transparent substrate; s3, mixing and forming: mixing the medicinal powder raw materials and the transparent matrix according to the mass ratio of (2.07-1): 2.13, uniformly stirring at 85-90 DEG C, cooling, solidifying, sterilizing and packaging to obtain the eczema cream. According to the standardized preparation process and the quality inspection method of the eczema cream, by optimizing superfine grinding parameters, a matrix ratio and a quality control system, stable production and quality controllability of the eczema cream are achieved, and technical support is provided for preparation conversion.

The application relates to the technical field of computer-aided design. By providing an AI all-ceramic crown bionic design and mechanical property optimization method based on deep learning, the method comprises the following steps: generating an initial crown geometric model based on crown design space constraints by using a physically embedded generative adversarial network; predicting the mechanical properties of the initial crown geometric model and outputting stress distribution data; simulating the manufacturing deformation process of the initial crown geometric model to obtain manufacturing deformation prediction data; fusing the physical field gradient of the stress distribution data and the manufacturing deformation prediction data to obtain optimization gradient data; updating the physically embedded generative adversarial network by using the optimization gradient data to obtain an optimized crown shape; and converting the optimized crown shape into an executable manufacturing instruction set, so that the technical effects of improving the anatomical shape adaptation accuracy, enhancing the mechanical property prediction accuracy and reducing the design optimization iteration number are achieved, and the clinical applicability of the crown product is improved.

This invention discloses a positioning stent for convenient fixation and safe removal within human blood vessels, relating to the field of surgical medical device technology. The positioning stent comprises: a metal wire stent with multiple pointed positioning spikes, each spike including an inner metal wire and a covering layer; the inner metal wire is connected to the metal wire of the metal wire stent, the diameter of the inner metal wire being smaller than the diameter of the metal wire of the metal wire stent; the covering layer is conical and made of a biodegradable material; the tips of the inner metal wires and the tips of the covering layer are spaced a predetermined distance apart, and the middle portion of the inner metal wire forms a spiral portion; after the covering layer degrades, the spiral portion changes from a compressed state to an extended state, allowing the inner metal wire to pierce the blood vessel wall, with a predetermined gap between the blood vessel wall surface and the surface of the metal wire stent. This invention achieves reliable stent fixation and safe removal.

The application provides a kind of mitochondria-targeted palladium-doped finger citron carbon dot nanomaterial and a preparation method thereof.The preparation method uses natural plant finger citron as raw material, through hydrothermal reaction, cooling, centrifugation, dialysis, freeze-drying and other steps, extracts natural carbon dots from finger citron, and then dopes palladium and mitochondria-targeted peptide, finally obtains mitochondria-targeted palladium-doped finger citron carbon dot nanomaterial (PDs@SS31).The mitochondria-targeted palladium-doped finger citron carbon dot nanomaterial prepared by the application can form a multifunctional synergistic treatment system in combination with a near-infrared light irradiation device.The system has high-efficiency ROS scavenging, precise mitochondria targeting, near-infrared response and immune regulation functions, has excellent biocompatibility, can effectively activate the mitochondrial autophagy pathway, and can significantly improve the treatment effect of acute lung injury by specifically reprogramming the oxidation-reduction homeostasis in the lung microenvironment.

The invention relates to the technical field of medical instruments, in particular to a shoulder joint auxiliary reduction device which comprises a rib arc plate, an arm arc plate and a connecting part of the rib arc plate and the arm arc plate. The connecting part comprises an outer cylinder and an inner rod, the outer cylinder is fixedly connected to the rib arc plate, the inner rod is rotatably connected to the top end of the arm arc plate, and the inner rod is slidably connected into the outer cylinder; the distance between the rib arc plate and the arm arc plate is adjusted through the connecting piece, and shoulder joint restoration is assisted; the two ends of the soft cushion are fixedly connected to the outer ends of the outer cylinder and the inner rod respectively. Through the limiting clamping piece and a ratchet mechanism, the inner rod can be subjected to one-way sliding adjustment in the outer cylinder, and therefore it is ensured that the position is accurately controlled in the force application process. The shoulder joint reduction assisting device assists in shoulder joint reduction through the Hippockets method, the stress area is increased, and the possibility of nerve injury is reduced.

This invention provides a low-latency infusion sensing alarm module, system, and application control. Through innovative composite sensing technology, TDMA low-latency communication architecture, and end-edge-backend three-level linkage mechanism, it completely solves the pain points of existing technologies, realizes fully automatic unattended monitoring and accurate alarm of clinical infusion, ensures medical safety, and reduces the burden on nurses, patients, and caregivers throughout the entire process.

The invention provides a low-dose CT image self-supervision denoising method based on axial structure consistency, and belongs to the technical field of medical image processing and deep learning. The method comprises the following steps of: inputting a DICOM (Digital Imaging and Communications in Medicine) image sequence scanned by original LDCT (Level Discrete Cosine Transform), extracting three continuous axial slices to generate a triple sample data set, and calculating an axial difference image of two adjacent slices to construct a two-tuple data set; the method comprises the following steps: after constructing a double-branch neural network framework of a denoising network and a difference enhancement network, respectively outputting a denoised triple and axial structure offset estimation, and calculating a pseudo-supervision signal; and on the basis of the pseudo-supervised signal and the denoised triple, calculating by constructing a self-supervised joint loss optimization function to obtain a model for denoising the low-dose CT image. According to the method, the problems of axial structure dislocation, high-frequency detail loss, excessive smoothness and the like in an existing self-supervised denoising method are effectively solved, and the structural consistency and detail fidelity of the image are remarkably improved while noise suppression is ensured.

The utility model discloses a two -axis manipulator for MRI HIFU, including adopting translation - rotation double axle architecture, through limited degree of freedom and realizes the plane positioning and angle adjustment of HIFU transducer, adopts non - magnetic material to make, specifically including structure shell, rotation transmission mechanism, rotary frame, translation transmission mechanism and limiting mechanism, wherein, rotation transmission mechanism, rotary frame, translation transmission mechanism and limiting mechanism set up in structure shell, the utility model provides a two -axis manipulator for MRI HIFU, adopts translation - rotation double axle architecture, through limited degree of freedom and realizes the plane positioning and angle adjustment of HIFU transducer, utilizes non - magnetic material and drive scheme, realizes zero electromagnetic interference, cooperates PID algorithm and MRI temperature control data linkage, and response delay is less than 50ms, supports transducer quick replacement, adapts 3MHz 8MHz multiple frequency's HIFU probe, expands clinical application scene.

This invention relates to the field of biomedical detection technology, specifically to a multiplex TMA-CRISPR detection kit for respiratory pathogen RNA and its application. This invention solves the problems of weak sensitivity and signal recognition issues in existing multiplex detection based on direct RNA amplification technology and CRISPR multiplex detection. Firstly, by screening specific TMA primers and crRNA for IAV, IBV, RSVA, and RSVB, and optimizing the TMA-CRISPR system with specific enzyme ratios and buffers, and combining TMA amplification with Cas12a2 lateralization activity, the constructed multiplex TMA-CRISPR kit can achieve 10 copies / μL RNA detection within 40 minutes. Clinical detection results are highly consistent with qRT-PCR and are more sensitive, making it suitable for rapid multiplex diagnosis of respiratory pathogens.

The present application relates to the technical field of three-dimensional reconstruction and intelligent analysis of medical images, and specifically discloses a preoperative virtual reconstruction system for thoracic surgery, which constructs a spatial graph structure with voxels as nodes and introduces respiratory motion displacement trajectories as dynamic attributes; extracts and fuses static structural features and dynamic motion features to generate context feature vectors rich in anatomical and functional information; in a serialized topological constraint segmentation module, the graph nodes are sorted according to topological geodetic distance and feature saliency, and hierarchical segmentation from trunk to periphery is realized by combining anatomical topological constraints based on a rule base and a sequence prediction model; connectivity test, fracture repair and geometric reasonableness verification are performed to output a high-quality preoperative virtual reconstruction three-dimensional model that is accurate, error-free and consistent with anatomical rules.

The application discloses a set of bile acid marker combinations, kits and applications for female sarcopenia patients with liver fibrosis risk stratification. The bile acid marker combinations are GCA, GDCA, GCDCA, TDCA, TDCA-3S, TCDCA, GLCA-3S and GDCA-3S in serum or plasma. Through quality control, difference screening and multi-model verification, a joint scoring model is constructed to distinguish the basic bile acid metabolism type and the liver fibrosis susceptible type subgroup. The experimental results show that the AUC of the model verification queue reaches 0.982; the median of the susceptible type subgroup LSM is 6.0 kPa, and the high-risk proportion is 20.7%, which is significantly higher than that of the basic type. The application can realize early and accurate stratification of the liver fibrosis risk of female sarcopenia patients, and is especially suitable for clinical screening and risk assessment.

This invention discloses an utpatinib sustained-release tablet and its preparation method, characterized by comprising the active ingredient utpatinib and excipients, wherein the excipients include filler 1, filler 2, a matrix material, a lubricant, a flow aid, and a coating material; filler 1 is a combination of different types of microcrystalline cellulose, filler 2 is mannitol or lactose, and the matrix material is a mixture of polyvinyl acetate and povidone (Kollidon® SR). The formulation prepared by this invention solves the degradation problem encountered in the preparation of utpatinib sustained-release tablets, simplifies the production steps and facilitates commercial production, and also solves the problem of utpatinib relying on pH adjusters to enhance solubility, and has good stability and high mixing uniformity.

This invention discloses a nebulization device for traditional Chinese medicine (TCM) internal medicine, belonging to the field of medical device technology. It includes a mask assembly, a main nebulizer assembly, and a control panel. The mask assembly is detachable and connects to the main nebulizer assembly, while the control panel centrally controls all components. The mask assembly features a negative pressure suction structure. The main nebulizer assembly integrates an nebulizer, a pressurization chamber assembly, a pump assembly with a conical filter head, and an air supply assembly. A heating element is built into the connecting pipe, and a one-way valve is installed at the pipe connection. The pump rollers are covered with rubber pads. This device features a securely fixed mask, fine and thorough atomization of the medication, and can assist in medication delivery and heating. It is suitable for different patients, and its modular design facilitates cleaning and maintenance, improving medication efficacy and patient experience, thus meeting the clinical needs of TCM internal medicine nebulization.

The invention discloses a position self-supervised colorectum CT image lesion identification and positioning method, which significantly reduces the workload of doctors through automatic image level classification and Patch level positioning, reduces the dependence on annotation data through self-supervised learning, and specifically comprises the steps of constructing a multi-modal CT scanning sequence data set, selecting and annotating key frames, preprocessing images, and identifying the lesion of the colorectum CT image. Constructing and training a colorectum CT image recognition and positioning network; the network comprises an image-level classification branch and a Patch-level positioning branch, and the Patch-level positioning branch enhances lesion area recognition through a lesion position self-supervision module; the method further comprises time sequence and modal consistency constraint so as to improve the accuracy of lesion area positioning. In addition, according to the method, through a mask correction loop strategy, the consistency of category labels and lesion positions is enhanced; as an auxiliary tool, the method can effectively assist doctors in surgical planning and treatment selection, and has important clinical application value.

The invention relates to a sprayable lipid liquid crystal gel precursor containing a periplaneta americana freeze-dried concentrate as well as a preparation method and application thereof, belongs to the technical field of pharmaceutical preparations, and solves the problems that an existing gel dosage form containing a periplaneta americana extract adopts a water-based gel matrix with high water content, a high-dose preservative needs to be added, and the cost is high. And the damaged skin is possibly stimulated. The lipid liquid crystal gel precursor comprises the following main active ingredients in percentage by mass: 1%-6% of periplaneta americana freeze-dried concentrate, 0.05%-1% of SOD (superoxide dismutase), 0.5%-3% of triethanolamine, 20%-30% of SPC (sodium phosphate), 50%-60% of GDO (glucose dissolved oxygen) and 5%-15% of absolute ethyl alcohol. The preparation method comprises the following steps: 1, preparing a liquid crystal matrix phase and an active component phase; and 2, uniformly mixing the liquid crystal matrix phase and the active component phase according to a mass ratio of (85-90): (10-15) to obtain the lipid liquid crystal gel precursor.

The invention discloses a tonsil postoperative diet management system and method, and relates to the technical field of medical care, and the system comprises a front end, a rear end, a database, an image recognition module and an intelligent interaction module. All the parts collaboratively realize the following functions: a data management function, a system management function, an authority management function, an automatic recipe recommendation function, an image recognition function and an interactive forum function. The personalized diet recipe can be automatically recommended according to the basic information, the medical history, the number of postoperative days and the tonsil mucosa recovery condition of the patient, meanwhile, an interaction platform between a doctor and the patient is built, and the problems that existing clinical diet guidance is general, individuation is lacked and doctor-patient communication is inconvenient are solved.

The invention belongs to the technical field of biological detection, and particularly relates to a biomarker combination for predicting the postoperative recurrence risk of a phase I non-small cell lung cancer patient and application of the biomarker combination, and the biomarker combination comprises one or more of the following 15 proteins: HMGB3, CKAP4, GAPDH, NAMPT, GFPT2, TPSAN1, EIF4G2, PRKDC, ACOT7, LRRC59, DDX17, AK1, PABPC1L, PYCR1 and ALDOA. The biomarker combination is used for predicting the postoperative recurrence risk of the I-stage non-small cell lung cancer patient, the clinical applicability is high, the prediction performance is excellent, accurate layering of the postoperative recurrence risk of the I-stage non-small cell lung cancer patient can be achieved, individualized follow-up visit and adjuvant therapy decision can be effectively guided, and the biomarker combination has remarkable clinical application value.

This invention provides a control suture reel, a suture hole handle, and a ligator, relating to the field of medical device technology. The control suture reel rotates in a first direction to wind up the suture and drive the working part. It has at least one locking part circumferentially, each locking part comprising a trigger locking position and a pre-tensioning locking position arranged sequentially in opposite directions: when the trigger locking position is locked, the corresponding ligature loop is released; when the pre-tensioning locking position is locked, the suture is wound up and tensioned. This dual-locking structure achieves physical separation and timing control of tensioning and triggering, eliminating redundant bending, restoring the straightness of the release suture, and avoiding obstruction of vision and tissue adhesion. The pre-tensioning stage provides disturbance-free correction of the suture posture, and the triggering stage initiates with low inertia, significantly suppressing mechanical tissue damage caused by vibration and slippage. It improves the reliability, safety, and ergonomics of multi-turn sequential release, meeting the needs of high-precision, low-invasive endoscopic interventional treatment.

This utility model relates to the field of drainage tube technology, specifically to a drainage tube fixing device and a drainage tube. It addresses the problem that traditional drainage tube fixing devices use stickers, which easily cause the drainage tube to detach from the sticker, rendering it unusable and unable to reliably fix the drainage tube. Therefore, it enhances the efficiency and effectiveness of the drainage tube fixing device. The device includes a medical support, bolts, and a sliding plate. The sliding plate is slidably connected to the corresponding medical support. The height of the sliding plate on the medical support is adjusted by turning the bolts. A fixing mechanism is provided on one side of the sliding plate. The fixing mechanism further includes a drainage tube body, a base plate, a fixing frame, a first clamping plate, a second clamping plate, and a first lead screw. Clamping grooves are provided on the opposing surfaces of the first and second clamping plates. The drainage tube body is located between the first and second clamping plates.

The invention provides conductive hydrogel based on Schiff base crosslinking and tannic acid green rGO as well as a preparation method and application of the conductive hydrogel, and belongs to the technical field of biomedical materials. The preparation method of the conductive hydrogel comprises the following steps: reducing graphene oxide by using tannic acid to prepare TA-rGO; uniformly dispersing the TA-rGO in water, so as to obtain a TA-rGO dispersion liquid; adding carboxymethyl chitosan into the TA-rGO dispersion liquid to obtain a mixed liquid; and adding an oxidized hyaluronic acid aqueous solution into the mixed solution under a stirring condition, uniformly mixing, and standing to obtain the conductive hydrogel. An integrated three-dimensional network structure is cooperatively constructed through dynamic covalent Schiff base crosslinking and multiple non-covalent interaction, the material is endowed with high conductive stability, excellent mechanical toughness, self-repairing capacity, antibacterial / antioxidant activity and good biocompatibility, and it is achieved that the material is combined with electrical stimulation to accelerate healing of diabetic wounds.

The application belongs to the field of biology and particularly relates to a composition of a biosensor for detecting APE1, a working solution and a product, the composition comprising a double-stranded promoter, an H1 hairpin, an H2 hairpin and an FQ reporter molecule, the double-stranded promoter comprising a promoter I and a blocking chain B, and the FQ reporter molecule comprising a RepF chain and a RepQ chain, the biosensor formed by the composition of the application has high sensitivity and strong specificity for detecting APE1.

The invention discloses a serum fibroblast activation protein detection kit based on latex microspheres, a detection method and application, and belongs to the technical field of biological reagents for diagnosis. The core breakthrough of the invention lies in that a dual-specificity system of latex microsphere specific adsorption and FAP targeted immunofluorescence coupling is constructed, and efficient and stable capture of the exosome is realized by virtue of the high specific surface area of the aldehyde group / sulfate latex microspheres and the specific interaction of the aldehyde group-amino group; and a high-affinity rabbit monoclonal anti-FAP antibody and a streptavidin-PE signal amplification system are matched, so that the detection problem of low-abundance FAP + Exo in an early tumor sample is successfully solved. Meanwhile, the integrity of the exosome structure and the FAP native conformation is guaranteed through the mild reaction conditions in the whole process, background interference is effectively deducted through a triple control system, and the accuracy and repeatability of the detection result are guaranteed.