17results about How to "Good clinical applicability" patented technology

The preparation process of the eczema cream comprises the following steps: S1, raw material pretreatment: coarsely crushing calcined calamine; removing impurities from cortex phellodendri, coarsely crushing, and removing impurities from indigo naturalis for later use; mixing the three components, performing superfine grinding, and sieving with a 100-mesh sieve to obtain a medicinal powder raw material; s2, substrate preparation: melting and stirring beeswax and sesame oil at 85-90 DEG C, and cooling to obtain a transparent substrate; s3, mixing and forming: mixing the medicinal powder raw materials and the transparent matrix according to the mass ratio of (2.07-1): 2.13, uniformly stirring at 85-90 DEG C, cooling, solidifying, sterilizing and packaging to obtain the eczema cream. According to the standardized preparation process and the quality inspection method of the eczema cream, by optimizing superfine grinding parameters, a matrix ratio and a quality control system, stable production and quality controllability of the eczema cream are achieved, and technical support is provided for preparation conversion.

The application relates to the technical field of computer-aided design. By providing an AI all-ceramic crown bionic design and mechanical property optimization method based on deep learning, the method comprises the following steps: generating an initial crown geometric model based on crown design space constraints by using a physically embedded generative adversarial network; predicting the mechanical properties of the initial crown geometric model and outputting stress distribution data; simulating the manufacturing deformation process of the initial crown geometric model to obtain manufacturing deformation prediction data; fusing the physical field gradient of the stress distribution data and the manufacturing deformation prediction data to obtain optimization gradient data; updating the physically embedded generative adversarial network by using the optimization gradient data to obtain an optimized crown shape; and converting the optimized crown shape into an executable manufacturing instruction set, so that the technical effects of improving the anatomical shape adaptation accuracy, enhancing the mechanical property prediction accuracy and reducing the design optimization iteration number are achieved, and the clinical applicability of the crown product is improved.

This invention discloses a positioning stent for convenient fixation and safe removal within human blood vessels, relating to the field of surgical medical device technology. The positioning stent comprises: a metal wire stent with multiple pointed positioning spikes, each spike including an inner metal wire and a covering layer; the inner metal wire is connected to the metal wire of the metal wire stent, the diameter of the inner metal wire being smaller than the diameter of the metal wire of the metal wire stent; the covering layer is conical and made of a biodegradable material; the tips of the inner metal wires and the tips of the covering layer are spaced a predetermined distance apart, and the middle portion of the inner metal wire forms a spiral portion; after the covering layer degrades, the spiral portion changes from a compressed state to an extended state, allowing the inner metal wire to pierce the blood vessel wall, with a predetermined gap between the blood vessel wall surface and the surface of the metal wire stent. This invention achieves reliable stent fixation and safe removal.

This invention provides a low-latency infusion sensing alarm module, system, and application control. Through innovative composite sensing technology, TDMA low-latency communication architecture, and end-edge-backend three-level linkage mechanism, it completely solves the pain points of existing technologies, realizes fully automatic unattended monitoring and accurate alarm of clinical infusion, ensures medical safety, and reduces the burden on nurses, patients, and caregivers throughout the entire process.

The invention provides a low-dose CT image self-supervision denoising method based on axial structure consistency, and belongs to the technical field of medical image processing and deep learning. The method comprises the following steps of: inputting a DICOM (Digital Imaging and Communications in Medicine) image sequence scanned by original LDCT (Level Discrete Cosine Transform), extracting three continuous axial slices to generate a triple sample data set, and calculating an axial difference image of two adjacent slices to construct a two-tuple data set; the method comprises the following steps: after constructing a double-branch neural network framework of a denoising network and a difference enhancement network, respectively outputting a denoised triple and axial structure offset estimation, and calculating a pseudo-supervision signal; and on the basis of the pseudo-supervised signal and the denoised triple, calculating by constructing a self-supervised joint loss optimization function to obtain a model for denoising the low-dose CT image. According to the method, the problems of axial structure dislocation, high-frequency detail loss, excessive smoothness and the like in an existing self-supervised denoising method are effectively solved, and the structural consistency and detail fidelity of the image are remarkably improved while noise suppression is ensured.

This invention relates to the field of biomedical detection technology, specifically to a multiplex TMA-CRISPR detection kit for respiratory pathogen RNA and its application. This invention solves the problems of weak sensitivity and signal recognition issues in existing multiplex detection based on direct RNA amplification technology and CRISPR multiplex detection. Firstly, by screening specific TMA primers and crRNA for IAV, IBV, RSVA, and RSVB, and optimizing the TMA-CRISPR system with specific enzyme ratios and buffers, and combining TMA amplification with Cas12a2 lateralization activity, the constructed multiplex TMA-CRISPR kit can achieve 10 copies / μL RNA detection within 40 minutes. Clinical detection results are highly consistent with qRT-PCR and are more sensitive, making it suitable for rapid multiplex diagnosis of respiratory pathogens.

The present application relates to the technical field of three-dimensional reconstruction and intelligent analysis of medical images, and specifically discloses a preoperative virtual reconstruction system for thoracic surgery, which constructs a spatial graph structure with voxels as nodes and introduces respiratory motion displacement trajectories as dynamic attributes; extracts and fuses static structural features and dynamic motion features to generate context feature vectors rich in anatomical and functional information; in a serialized topological constraint segmentation module, the graph nodes are sorted according to topological geodetic distance and feature saliency, and hierarchical segmentation from trunk to periphery is realized by combining anatomical topological constraints based on a rule base and a sequence prediction model; connectivity test, fracture repair and geometric reasonableness verification are performed to output a high-quality preoperative virtual reconstruction three-dimensional model that is accurate, error-free and consistent with anatomical rules.

The application discloses a set of bile acid marker combinations, kits and applications for female sarcopenia patients with liver fibrosis risk stratification. The bile acid marker combinations are GCA, GDCA, GCDCA, TDCA, TDCA-3S, TCDCA, GLCA-3S and GDCA-3S in serum or plasma. Through quality control, difference screening and multi-model verification, a joint scoring model is constructed to distinguish the basic bile acid metabolism type and the liver fibrosis susceptible type subgroup. The experimental results show that the AUC of the model verification queue reaches 0.982; the median of the susceptible type subgroup LSM is 6.0 kPa, and the high-risk proportion is 20.7%, which is significantly higher than that of the basic type. The application can realize early and accurate stratification of the liver fibrosis risk of female sarcopenia patients, and is especially suitable for clinical screening and risk assessment.

This invention discloses an utpatinib sustained-release tablet and its preparation method, characterized by comprising the active ingredient utpatinib and excipients, wherein the excipients include filler 1, filler 2, a matrix material, a lubricant, a flow aid, and a coating material; filler 1 is a combination of different types of microcrystalline cellulose, filler 2 is mannitol or lactose, and the matrix material is a mixture of polyvinyl acetate and povidone (Kollidon® SR). The formulation prepared by this invention solves the degradation problem encountered in the preparation of utpatinib sustained-release tablets, simplifies the production steps and facilitates commercial production, and also solves the problem of utpatinib relying on pH adjusters to enhance solubility, and has good stability and high mixing uniformity.

This invention discloses a nebulization device for traditional Chinese medicine (TCM) internal medicine, belonging to the field of medical device technology. It includes a mask assembly, a main nebulizer assembly, and a control panel. The mask assembly is detachable and connects to the main nebulizer assembly, while the control panel centrally controls all components. The mask assembly features a negative pressure suction structure. The main nebulizer assembly integrates an nebulizer, a pressurization chamber assembly, a pump assembly with a conical filter head, and an air supply assembly. A heating element is built into the connecting pipe, and a one-way valve is installed at the pipe connection. The pump rollers are covered with rubber pads. This device features a securely fixed mask, fine and thorough atomization of the medication, and can assist in medication delivery and heating. It is suitable for different patients, and its modular design facilitates cleaning and maintenance, improving medication efficacy and patient experience, thus meeting the clinical needs of TCM internal medicine nebulization.

The invention relates to a sprayable lipid liquid crystal gel precursor containing a periplaneta americana freeze-dried concentrate as well as a preparation method and application thereof, belongs to the technical field of pharmaceutical preparations, and solves the problems that an existing gel dosage form containing a periplaneta americana extract adopts a water-based gel matrix with high water content, a high-dose preservative needs to be added, and the cost is high. And the damaged skin is possibly stimulated. The lipid liquid crystal gel precursor comprises the following main active ingredients in percentage by mass: 1%-6% of periplaneta americana freeze-dried concentrate, 0.05%-1% of SOD (superoxide dismutase), 0.5%-3% of triethanolamine, 20%-30% of SPC (sodium phosphate), 50%-60% of GDO (glucose dissolved oxygen) and 5%-15% of absolute ethyl alcohol. The preparation method comprises the following steps: 1, preparing a liquid crystal matrix phase and an active component phase; and 2, uniformly mixing the liquid crystal matrix phase and the active component phase according to a mass ratio of (85-90): (10-15) to obtain the lipid liquid crystal gel precursor.

The invention discloses a tonsil postoperative diet management system and method, and relates to the technical field of medical care, and the system comprises a front end, a rear end, a database, an image recognition module and an intelligent interaction module. All the parts collaboratively realize the following functions: a data management function, a system management function, an authority management function, an automatic recipe recommendation function, an image recognition function and an interactive forum function. The personalized diet recipe can be automatically recommended according to the basic information, the medical history, the number of postoperative days and the tonsil mucosa recovery condition of the patient, meanwhile, an interaction platform between a doctor and the patient is built, and the problems that existing clinical diet guidance is general, individuation is lacked and doctor-patient communication is inconvenient are solved.

The invention belongs to the technical field of biological detection, and particularly relates to a biomarker combination for predicting the postoperative recurrence risk of a phase I non-small cell lung cancer patient and application of the biomarker combination, and the biomarker combination comprises one or more of the following 15 proteins: HMGB3, CKAP4, GAPDH, NAMPT, GFPT2, TPSAN1, EIF4G2, PRKDC, ACOT7, LRRC59, DDX17, AK1, PABPC1L, PYCR1 and ALDOA. The biomarker combination is used for predicting the postoperative recurrence risk of the I-stage non-small cell lung cancer patient, the clinical applicability is high, the prediction performance is excellent, accurate layering of the postoperative recurrence risk of the I-stage non-small cell lung cancer patient can be achieved, individualized follow-up visit and adjuvant therapy decision can be effectively guided, and the biomarker combination has remarkable clinical application value.

This invention provides a control suture reel, a suture hole handle, and a ligator, relating to the field of medical device technology. The control suture reel rotates in a first direction to wind up the suture and drive the working part. It has at least one locking part circumferentially, each locking part comprising a trigger locking position and a pre-tensioning locking position arranged sequentially in opposite directions: when the trigger locking position is locked, the corresponding ligature loop is released; when the pre-tensioning locking position is locked, the suture is wound up and tensioned. This dual-locking structure achieves physical separation and timing control of tensioning and triggering, eliminating redundant bending, restoring the straightness of the release suture, and avoiding obstruction of vision and tissue adhesion. The pre-tensioning stage provides disturbance-free correction of the suture posture, and the triggering stage initiates with low inertia, significantly suppressing mechanical tissue damage caused by vibration and slippage. It improves the reliability, safety, and ergonomics of multi-turn sequential release, meeting the needs of high-precision, low-invasive endoscopic interventional treatment.

The invention provides conductive hydrogel based on Schiff base crosslinking and tannic acid green rGO as well as a preparation method and application of the conductive hydrogel, and belongs to the technical field of biomedical materials. The preparation method of the conductive hydrogel comprises the following steps: reducing graphene oxide by using tannic acid to prepare TA-rGO; uniformly dispersing the TA-rGO in water, so as to obtain a TA-rGO dispersion liquid; adding carboxymethyl chitosan into the TA-rGO dispersion liquid to obtain a mixed liquid; and adding an oxidized hyaluronic acid aqueous solution into the mixed solution under a stirring condition, uniformly mixing, and standing to obtain the conductive hydrogel. An integrated three-dimensional network structure is cooperatively constructed through dynamic covalent Schiff base crosslinking and multiple non-covalent interaction, the material is endowed with high conductive stability, excellent mechanical toughness, self-repairing capacity, antibacterial / antioxidant activity and good biocompatibility, and it is achieved that the material is combined with electrical stimulation to accelerate healing of diabetic wounds.

The application belongs to the field of biology and particularly relates to a composition of a biosensor for detecting APE1, a working solution and a product, the composition comprising a double-stranded promoter, an H1 hairpin, an H2 hairpin and an FQ reporter molecule, the double-stranded promoter comprising a promoter I and a blocking chain B, and the FQ reporter molecule comprising a RepF chain and a RepQ chain, the biosensor formed by the composition of the application has high sensitivity and strong specificity for detecting APE1.

The invention discloses a serum fibroblast activation protein detection kit based on latex microspheres, a detection method and application, and belongs to the technical field of biological reagents for diagnosis. The core breakthrough of the invention lies in that a dual-specificity system of latex microsphere specific adsorption and FAP targeted immunofluorescence coupling is constructed, and efficient and stable capture of the exosome is realized by virtue of the high specific surface area of the aldehyde group / sulfate latex microspheres and the specific interaction of the aldehyde group-amino group; and a high-affinity rabbit monoclonal anti-FAP antibody and a streptavidin-PE signal amplification system are matched, so that the detection problem of low-abundance FAP + Exo in an early tumor sample is successfully solved. Meanwhile, the integrity of the exosome structure and the FAP native conformation is guaranteed through the mild reaction conditions in the whole process, background interference is effectively deducted through a triple control system, and the accuracy and repeatability of the detection result are guaranteed.