84results about How to "Good clinical applicability" patented technology

The invention discloses a clinical acupuncture evidence-based decision support system and an application method thereof. The system comprises a data preprocessing module, a data importing and updating module, an electronic medical record module, a diagnosis decision-making module, a treat decision-making module, a system auxiliary module, a result output module and a databank. According to the system, decision-making mechanisms of the evidence-based medicine are blended into a decision-making scheme of a CDSS (Clinical Decision Support System), the evidence utilization is used as the core, an electronic medical record technique is embedded into a clinical acupuncture diagnosis and treat process so as to integrate an evidence-based databank and a data mining model, a clinical acupuncture evidence-based auxiliary support system in which the evaluation, storage, analysis and utilization of acupuncture research evidences are integrated is established, and a convenient and rapid man-machine interaction platform is provided for the effective utilization of the acupuncture research evidences. With the adoption of the system, the requirements of doctors in the overall clinical diagnosis and treat process are met well, and the alternative thinking process of diagnosis and treat is effectively supported, so that a treat scheme which is proposed finally is an optimal scheme obtained from literature evaluation, so that the clinical acupuncture evidence-based decision support system has relatively high clinical adaptation.

The invention discloses an evaluating system of depressive disorder degree quantization. The system comprises an electrocardio and pulse wave integral detection device, a data transmission device and a data processing platform. The invention further discloses an evaluating method of depressive disorder degree quantization. The method comprises the following steps that firstly, human physiological information under different states is acquired through a multi-state comprehensive test platform; secondly; HRV characteristic parameters under the different states are obtained on the basis of the heart rate variability analysis principle; thirdly, the function balance states of sympathetic nerves and pneumogastric nerves in the automatic nervous system are evaluated; fourthly, a depressive disorder degree quantization evaluation model is built, and the depressive disorder degree level of a tested person is evaluated fast and objectively. The system and method belong to the technical field of computer-aided diagnosis, depressive disorder degree quantization evaluation is achieved, the blank of the technical field of depressive disorder inspection is filled up, and the system and method are easy and convenient to implement, save medical resources and have the good clinic practicality.

The invention relates to a surgical navigation simulation method based on an electromagnetic positioning technology and intraoperative image guidance. The surgical navigation simulation method comprises the steps that 1, a preoperatively shot CT image of a patient is obtained; 2, the preoperatively shot CT image of the patient is reconstructed into a three-dimensional CT model; 3, registration andvisualization of surgical instruments are achieved; 4, the electromagnetic positioning technology is utilized to achieve real-time tracing of the surgical instruments under an image coordinate system; 5, an ultrasonic probe is calibrated, an ultrasonic image is obtained during operation in real time, and preliminary fusion between the three-dimensional CT model and the ultrasonic image is achieved; 6, by utilizing grey information and characteristic information of the ultrasonic image and adopting a mutual information method and an automatic SIFT characteristic extraction method, real-time registering of the preoperative three-dimensional CT model and the intraoperative ultrasonic image in the surgical process is performed; 7, simulation control of surgical robot movements is achieved. Compared with the prior art, the surgical navigation simulation method has the advantages of high navigation precision, low calculation complexity, good stability and reliability, convenient achievement, low cost, good clinic applicability and the like.

The invention provides a responsive polymeric system, comprising: a polymeric responsive component capable of undergoing a transition that results in a sharp increase in viscosity in response to a change in temperature at a predetermined body site; wherein the polymeric component comprises hydrophilic and hydrophobic segments covalently bound within the polymer component, by at least one chain extender or coupling agent, having at least 2 functional groups; wherein the hydrophilic and hydrophobic segments do not display Reverse Thermal Gelation behavior of their own at clinically relevant temperatures and; wherein the viscosity of the polymeric component increases by at least about 2 times upon exposure to a predetermined trigger.

The invention discloses a trypsin micropore plate type magnetic granule chemoluminescence immunoassay measuring kit and a preparation method thereof. The kit comprises: (1) a trypsin calibration sample, (2) magnetic granules coated by a trypsin monoclonal antibody, (3) another monoclonal antibody or a polyclonal antibody marked by alkaline phosphatase (ALP), (4) a micropore plate, (5) washing solution and (6) chemoluminescence substrate solution on which the enzyme acts. The preparation method for preparing the kit comprises the steps of preparing the calibration sample, preparing the magnetic granules coated by the trypsin antibody, marking the trypsin antibody with the alkaline phosphatase (ALP), preparing the washing solution and preparing the chemoluminescence substrate solution. The kit can carry out batch measurement and is suitable for batch clinic blood serum screening.

The invention relates to the medical field of immunoassay, and concretely provides a dissociate human chorionic gonadotrophin beta-subunit magnetic particle chemiluminescence quantitative assay kit having the advantages of simplicity, rapidness, high sensitivity, wide linear range and good stability, and its preparation method. The method combines a magnetic particle immune separating technology to apply an enzymatic chemiluminescence substrate on the basis of enzyme-linked immunosorbent assay, and allows an optical signal generated by the detection of the luminescence substrate to substitute a chromogenic substrate in enzyme immune assay, so the method has the advantages of substantially improved sensitivity, simple operation and wide practicality, can be applied to open semi-automatic chemiluminescence detectors, can also be applied to full-automatic measure systems, and can realize batch and fast detection, low use cost, and easy popularization and application.

The invention relates to the medical field of immunoassay, more specially, the invention provides a chemiluminescent immunoassay detection kit for free prostate specific antigens and a preparation method thereof. The kit of the invention comprises: 1) free prostate specific antigen calibrators, 2) solid-phase vectors which are coated by prostate specific antigen monoclonal antibodies, 3) anti-free prostate specific antigen antibodies which are marked by enzyme and 4) chemiluminescent substrate solutions. Further, the preparation method of the kit according to the invention comprises the following steps: 1) preparing the calibrators, 2) coating the solid-phase vectors with the free prostate specific antigen monoclonal antibodies, 3) marking the anti-free prostate specific antigen antibodies with the enzyme, 4) packaging the calibrators, the enzyme markers and chemiluminescent substrate solutions, and 5) assembling finished products. The kit of the invention has the advantages of convenience, rapidness, sensitivity, stability, and the like.

The invention discloses a tooth occlusion analysis system based on point cloud spatial characteristics. The system comprises a data acquisition unit, a preprocessing unit, an overlapping region positioning unit, a point cloud registration unit and an occlusion analysis unit; the data acquisition unit is used for acquiring tooth jaw point cloud data and tooth point cloud data of the same case in different periods; the preprocessing unit is used for extracting and obtaining auxiliary point cloud data based on the tooth jaw point cloud data and the tooth point cloud data; the overlapping region positioning unit determines an overlapping region according to the tooth jaw point cloud data, the tooth point cloud data and the auxiliary point cloud data; the point cloud registration unit completes registration of dental jaw point cloud data of the same case in different periods based on the overlapped area; and the occlusion analysis unit performs tooth occlusion analysis based on the registered tooth jaw point cloud data. According to the method, the influence of low overlapping rate and noise on the matching effect can be reduced to the maximum extent, and the registration precision is greatly improved.

The invention provides an antigen stimulant for detecting mycobacterium tuberculosis infection, and a kit comprising the antigen stimulant. The invention also provides an application of the antigen stimulant in reagents for detecting mycobacterium tuberculosis infection. The antigen stimulant comprises at least one polypeptide or analogues thereof in polypeptides shown as the sequences 1-11 in a sequence table, wherein the polypeptides respectively come from tuberculosis specific antigen polypeptides ESAT-6 and tuberculosis specific antigen polypeptides CFP-10. According to the antigen stimulant provided by the invention, peripheral blood T lymphocytes of tuberculosis infection patients can be effectively stimulated to generate IFN-gamma, so that the tuberculosis infection can be diagnosed at high sensitivity and high specificity, and the influence on BCC inoculation or other underlying diseases can be avoided.

The invention provides a device for judging prognosis conditions of liver cancer patients based on an artificial neural network model. The device comprises: (1) an input module configured to input tumor feature information of a to-be-discriminated liver cancer patient; (2) a prognosis discrimination module which is set to comprise an artificial neural network model used for calculating the prognosis condition of the to-be-discriminated liver cancer patient based on the input information; and (3) an output module, wherein the output module is set to output the obtained prognosis condition. Theinvention also provides a method for grouping prognosis conditions of liver cancer patients by adopting the device.

The invention relates to a GLP-1 derivative including an amino acid sequence of GLP-1 (7-35) having deletion, substitution and/or addition of one or more amino acids and having Waa-(Xaa)n-Yaa (in which Waa is Arg or Lys, Xaa is Arg or Lys, n is an integer of 0 to 14, and Yaa is Arg, Arg-NH₂, Lys, Lys-NH₂ or Hse) added to the C-terminus of the peptide having a GLP-1 activity. These derivatives are derivatives highly absorbable via a mucous membrane. In the invention, the GLP-1 derivative can be conferred with resistance to dipeptidyl peptidase IV by substituting amino acid 8 in its GLP-1 amino acid sequence with Ser, or with resistance to trypsin by substituting amino acids 26 and 34 with Gln and Asn, respectively. The efficiency of absorption of the GLP-1 derivatives of the invention via mucous membranes can be further improved by preparing a composition using a charge-regulated fat emulsion regulated to be negatively charged thereon.

The invention discloses a molecular pathological classification method of diffuse large B-cell lymphomata, which use three quantum dot markers of different wavelengths as fluorescent probes to detect the expression of CD10, Bcl-6 and MUM1 proteins in a biological sample. The invention also discloses a kit for the molecular pathological classification of diffuse large B-cell lymphomata and an application thereof. The molecular pathological classification method of diffuse large B-cell lymphomata obviously improves the working efficiency, and can provide a rational regimen for patients with diffuse large B-cell lymphomata, thereby being beneficial to saving medical expenses.

The invention provides a brain tumor multi-target auxiliary diagnosis and prospective treatment evolution visualization method and system. The brain tumor multi-target auxiliary diagnosis and prospective treatment evolution visualization method comprises the steps: acquiring and preprocessing paired brain tumor multi-target multi-mode MRI data before and after treatment; carrying out tumor regionsegmentation on the preprocessed paired brain tumor multi-target multi-mode MRI data before and after treatment through a 3DU-net convolutional neural network, and obtaining a growth characteristic label L = {l1, l2, l3,..., ln} through an imaging omics method; and performing feature extraction on the sum through a multi-channel convolutional neural network and then performing SE fusion operationto obtain deep learning features and input the deep learning features into a prediction model to obtain a brain tumor multi-target growth prediction label, inputting the brain tumor multi-target growth prediction label into a trained prospective treatment visualization model to obtain a final brain tumor region-of-interest growth evolution image, and inserting the brain tumor region-of-interest growth evolution image into a non-brain tumor region Ibackground to complete a brain tumor prospective treatment visualization task. The method and system in the invention has higher clinical practicability.

The invention discloses Acipenser sinensis VTG protein antigen and antibody, and a preparation method and an application thereof. The preparation method comprises the following steps: 1, preparation of a recombinant Acipenser sinensis VTG protein antigen: 1) designing an upstream primer and a downstream primer, and amplifying a protein domain truncated sequence; 2) subjecting a pMD-18T-VTG plasmid and a Pet32a (+) expression vector to enzyme digestion by using EcoRI and XhoI, then purifying a target fragment, connecting the pMD-18T-VTG plasmid and the Pet32a (+) expression vector into Pet32a (+)-VTG, converting the Pet32a (+)-VTG into DH5a, coating the DH5a onto an ampicillin containing LB culture medium, and carrying out culturing; 3) converting the Pet32a (+)-VTG plasmid into a BL21(DE3) competent cell, coating the BL21(DE3) competent cell onto an ampicillin containing LB solid culture medium, and carrying out culturing; and 4) subjecting collected mycelium precipitate to resuspension precipitation by using an 8M urea containing protein buffer solution, then carrying out filtering, and collecting a supernatant so as to obtain a recombinant protein; 2, obtainment of an Acipenser sinensis VTG protein antibody through immunization of Japanese rabbit with the recombinant Acipenser sinensis VTG protein antigen; and 3, application of the Acipenser sinensis VTG protein antigen and antibody. The Acipenser sinensis VTG protein antibody and the VTG protein antigen provided by the invention have the following advantages: the immunity is good; a titer can reach 1: 1000; detection results have high positive rate; and the clinical applicability is good.

Methods for inducing, expanding, and/or generating alloantigen-specific regulatory T cells. Alloantigen-specific regulatory T cells can be induced, expanded, and/or generated from naive CD4⁺CD25⁻ T cells by using CD40-activated B cells. The regulatory T cells can be human T cells. In one embodiment, the alloantigen-specific human regulatory T cells can be CD4^highCD25⁺Foxp3⁺ regulatory T cells.

The invention discloses a medical care glove. The medical care glove is prepared from, by weight, 10-15 parts of diatomite with the surface modified with hydantoin, 65-75 parts of fluorine-containingdouble-end amino silicon oil-based benzanilide-based polycondensate and 10-20 parts of polyamide thermoplastic elastomer, wherein the fluorine-containing double-end amino silicon oil-based benzanilide-based polycondensate is prepared through condensation polymerization of 4,4'-diamino benzanilide, 3-ethynylbenzoic acid, polyether amine and 4-azido-2,3,5,6-tetrachloride phthalic anhydride. The invention further discloses a preparation method of the medical care glove. The medical care glove has the advantages of being remarkable in antibacterial effect, good in biocompatibility, high in strength and excellent in comprehensive performance.

The invention relates to a pharmaceutical composition for tumor immunotherapy, and provides a new application of radionuclide or a marker thereof, and the new application is an application of the radionuclide or the marker thereof in remodeling a tumor immunological microenvironment. The invention also provides a pharmaceutical composition for tumor immunotherapy of a human body or a mouse. The pharmaceutical composition is prepared from radionuclide or the marker thereof and an immune checkpoint inhibitor according to a specific ratio. The invention also provides a kit for tumor immunotherapy. The kit contains the pharmaceutical composition for tumor immunotherapy of human bodies or mice. According to the pharmaceutical composition provided by the invention, the tumor immune microenvironment can be remodeled while the tumor is detected through radionuclide or the marker thereof, so that the tumor growth speed is remarkably reduced through the immune checkpoint inhibitor, and the lifetime is prolonged. The pharmaceutical composition disclosed by the invention has a good synergistic effect, and the kit disclosed by the invention is convenient to use and easy to realize clinical popularization.

The invention discloses a preparation method of a vascular stent material. The preparation method comprises the following steps: (1) preparing chloromaleimide-terminated polycaprolactone, (2) preparing a copolymer, (3) modifying the copolymer with chitosan, (IV) synthesizing a furyl polyester condensation polymer, and (5) molding the stent. The invention also discloses the vascular stent preparedthrough the preparation method. The preparation method of the vascular stent material has the advantages of simplicity, easiness in implementation, and low preparation price; and the prepared vascularstent material has the advantages of good biocompatibility, excellent mechanical properties, excellent degradable performance, and safety and reliability in use.