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Vascular stent material and preparation method thereof

A technology of vascular stents and end groups, which is applied in the field of vascular stents and its preparation, can solve problems such as strength, poor oxidation resistance and toughness, insufficient mechanical properties, unfavorable blood vessel recovery, etc., so as to improve mechanical properties, mechanical properties and Excellent degradability and low hemolytic index

Active Publication Date: 2019-02-01
湖南博隽生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the defects in the prior art, the present invention aims to provide a safe and reliable vascular stent material with good biocompatibility, excellent mechanical properties and degradable properties, to effectively solve the problem of traditional degradable vascular stent materials or multiple Insufficient mechanical properties, poor strength, oxidation resistance and toughness, too fast degradation in the body, which is not conducive to blood vessel recovery, and will produce certain technical problems during the degradation process, while providing other technical problems Preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A preparation method for a vascular stent material, comprising the steps of:

[0038] Ⅰ Preparation of chloromaleic imide-terminated polycaprolactone: under nitrogen atmosphere, mix 20 g of maleic imide-terminated polycaprolactone with (E, Z)-1,4-dichloro-1 , Dissolve 1g of 3-butadiene in 40g of dimethyl sulfoxide to form a solution, and then add the solution into a three-neck flask equipped with a reflux condenser and an electric stirrer, reflux and stir at 120°C for 10 hours, and then spin evaporate Remove solvent, obtain chlorinated maleic acid imide terminal polycaprolactone;

[0039] Preparation of Ⅱ copolymer: 10 g of chloromaleimide-terminated polycaprolactone, 5 g of D-gluconate 2-propene-1-ester, 2-methyl lactate allyl Add 5g of ester and 0.1g of azobisisobutyronitrile into 100g of N-methylpyrrolidone, stir and react under nitrogen atmosphere at 70°C for 4 hours, then precipitate in acetone, and place the precipitated polymer in a vacuum Bake in a drying oven...

Embodiment 2

[0047] A preparation method for a vascular stent material, comprising the steps of:

[0048] Ⅰ Preparation of chloromaleic acid imide-terminated polycaprolactone: under a helium atmosphere, mix 20 g of maleic imide-terminated polycaprolactone with (E, Z)-1,4-dichloro- Dissolve 1g of 1,3-butadiene in 42g of N,N-dimethylformamide to form a solution, then add the solution into a three-neck flask equipped with a reflux condenser and an electric stirrer, and reflux and stir the reaction at 123°C After 10.5 hours, the solvent was removed by rotary evaporation to obtain chloromaleic acid imide-terminated polycaprolactone;

[0049] Preparation of Ⅱ copolymer: 10 g of chloromaleimide-terminated polycaprolactone, 5 g of D-gluconate 2-propene-1-ester, 2-methyl lactate allyl Add 5 g of ester and 0.13 g of azobisisoheptanonitrile to 105 g of N-methylpyrrolidone, stir and react under a helium atmosphere at 72°C for 4.5 hours, then precipitate in acetone, and place the precipitated polymer ...

Embodiment 3

[0057] A preparation method for a vascular stent material, comprising the steps of:

[0058] Ⅰ Preparation of chloromaleic imide-terminated polycaprolactone: under neon atmosphere, mix 20 g of maleic imide-terminated polycaprolactone with (E, Z)-1,4-dichloro- Dissolve 1 g of 1,3-butadiene in 45 g of N-methylpyrrolidone to form a solution, and then add the solution to a three-neck flask equipped with a reflux condenser and an electric stirrer, and react under reflux at 125°C for 11 hours, then Rotary evaporation removes solvent, obtains chlorinated maleic acid imide-terminated polycaprolactone;

[0059] Preparation of Ⅱ copolymer: 20 g of chloromaleimide-terminated polycaprolactone, 10 g of D-gluconate 2-propene-1-ester, 2-methyl lactate allyl Add 10g of ester and 0.3g of azobisisobutyronitrile into 230g of N-methylpyrrolidone, stir and react under a neon atmosphere at 75°C for 5 hours, then precipitate in acetone, and place the precipitated polymer in Dry in a vacuum oven at...

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Abstract

The invention discloses a preparation method of a vascular stent material. The preparation method comprises the following steps: (1) preparing chloromaleimide-terminated polycaprolactone, (2) preparing a copolymer, (3) modifying the copolymer with chitosan, (IV) synthesizing a furyl polyester condensation polymer, and (5) molding the stent. The invention also discloses the vascular stent preparedthrough the preparation method. The preparation method of the vascular stent material has the advantages of simplicity, easiness in implementation, and low preparation price; and the prepared vascularstent material has the advantages of good biocompatibility, excellent mechanical properties, excellent degradable performance, and safety and reliability in use.

Description

technical field [0001] The invention belongs to the technical field of three types of medical devices, and relates to an expandable implant prosthesis, in particular to a blood vessel stent and a preparation method thereof. Background technique [0002] At present, stent intervention is one of the main methods for treating cardiovascular diseases, and it is mainly used in the treatment of vascular lumen stenosis or embolization caused by vascular diseases, so as to improve blood flow and achieve the purpose of improving or treating diseases. The therapeutic effect of stent intervention depends on the choice of vascular stent material. The vascular stent material with ideal performance is a powerful guarantee to improve the success rate of operation and treatment effect and relieve the pain of patients. [0003] The stent materials commonly used in the prior art mainly include non-degradable vascular stent materials and degradable vascular stent materials. Non-degradable va...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/04A61L31/14D01F8/14D01F8/04D01F8/18
CPCA61L27/18A61L27/20A61L27/58A61L31/042A61L31/06A61L31/148D01F8/14D01F8/18C08L67/04C08L5/08C08L67/00
Inventor 邓生卫刘山明
Owner 湖南博隽生物医药有限公司
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