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A kind of veterinary allyl progesterone preparation and preparation method thereof

A technology of allylgestrine and its preparation, which is applied in the field of veterinary allylgestrine preparation and its preparation, can solve problems such as difficulty in uniform dispersion, high cost of medication, limited application, etc., and achieve improved production efficiency and industrial management level, good Bioabsorption utilization efficiency and effect, effect of shortening preparation time

Active Publication Date: 2021-04-30
NINGBO SANSHENG BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the oil solubility of allylgestrine, there is a precedent of dissolving allylgestrine in vegetable oil to make oil-based oral medicine in the prior art. However, during the research and preparation process of allylgestrine Allylgestrol can penetrate into target cells through its own fat solubility, but the efficiency of penetration is limited, resulting in low bioavailability, large dosage and high cost of medication, which greatly limits its clinical application in veterinary medicine; and In the preparation process of allylregestin oil preparation, allylregestin is first made into powder and then dispersed and dissolved in the oil agent. Because the powder is relatively small, it is easy to cause agglomeration and is not easy to disperse evenly.

Method used

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  • A kind of veterinary allyl progesterone preparation and preparation method thereof
  • A kind of veterinary allyl progesterone preparation and preparation method thereof
  • A kind of veterinary allyl progesterone preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～3

[0044] The veterinary allylgestrine preparations in Examples 1 to 3 are made from raw materials comprising the following mass percentages,

[0045] Allylprogesterone: 0.3-0.5%,

[0046] Benzyl alcohol: 0.9~1.1%,

[0047] Antioxidant: 0.012~0.016%,

[0048] β-carotene: 0.06~0.38%,

[0049] Omega-3 fatty acid: 0.07~0.25%,

[0050] Oil agent: balance.

[0051] The antioxidant is a mixture of tert-butyl-4-hydroxyanisole (BHA) and 2,6-di-tert-butyl-p-cresol (BHT), and the oil is peanut oil, soybean oil, palm oil or caprylic capric glyceride any one or more of them.

[0052] The raw materials and their mass percentages in Examples 1-3 are shown in Table 1.

[0053] Table 1: Each raw material and its mass percentage in Examples 1 to 4

[0054]

Embodiment 4

[0056] (1), prepare raw material by the raw material component and mass percentage among the embodiment 2, after solid raw material is crossed 60 mesh sieves, standby;

[0057] (2), after cooling 25% of the total weight of the oil extraction agent to 50°C, add an antioxidant and benzyl alcohol, and stir for 5min at a temperature of 50°C and a rotating speed of 120rpm to obtain an oil solution;

[0058] (3) Add allyl progesterone to ethanol, sonicate at 300w power for 2 minutes and then filter. After the oil solution is cooled to 30°C, add allyl progesterone, β-carotene, omega-3 The fatty acid and vitamin E were stirred for 10 minutes at a temperature of 30°C and a rotation speed of 120 rpm to obtain a primary liquid medicine;

[0059] (4) Add the primary medicinal liquid to the remaining oil agent, and stir for 10 minutes at a temperature of 20° C. and a rotational speed of 200 rpm to obtain a secondary medicinal liquid;

[0060] (5) Secondary filtration of the secondary drug...

Embodiment 5

[0062] (1), prepare raw material by the raw material component and mass percentage among the embodiment 2, after solid raw material is crossed 60 mesh sieves, standby;

[0063](2), after cooling 30% of the total weight of the oil extraction agent to 60°C, add antioxidant and benzyl alcohol, stir at 60°C and 100rpm for 10min to obtain an oil solution;

[0064] (3) Add allylgestrine to ethanol, and filter after ultrasonic treatment at 300w power for 4 minutes. After the oil solution is cooled to 35°C, add the treated allylgestrine, β-carotene, omega-3 The fatty acid and vitamin E were stirred for 15 minutes at a temperature of 35°C and a rotation speed of 100 rpm to obtain a primary liquid medicine;

[0065] (4) Add the primary medicinal liquid to the remaining oil agent, stir at 30°C and 180 rpm for 25 minutes to obtain the secondary medicinal liquid;

[0066] (5) Secondary filtration of the secondary drug solution through 50.0 μm and 30.0 μm filter membranes respectively to o...

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Abstract

The invention relates to a veterinary allylgestrine preparation and a preparation method thereof, belonging to the technical field of veterinary medicine. The veterinary allylgestrine preparation of the present invention is made of raw materials comprising the following mass percentages, 0.3-0.5% allylgestrine, 0.9-1.1% benzyl alcohol, 0.012-0.016% antioxidant, 0.06-0.38% β- Carotene, 0.07~0.25% omega-3 fatty acid. The allylgestrine preparation of the invention has good absorption effect, high bioavailability and good dispersion effect of the preparation.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and relates to a veterinary allylgestrine preparation and a preparation method thereof. Background technique [0002] Allylgestrol is a synthetic triene 21-carbon steroid progestogen belonging to 19-desmethyl-testosterone and is an orally active progestogen. Like all steroids, allylgestrol can penetrate into target cells through its own fat solubility and then bind to specific receptors to play a role, inhibiting the release of gonadotropins in a mode of action similar to natural progesterone. Allylgesterone inhibits the concentration of endogenous gonadotropins LH and FSH in the blood, causing the enlarged follicles (>20-25 mm) to shrink, thereby blocking estrus and ovulation. In the second half of the medication, when all the enlarged follicles shrink, there will be a peak of FSH secretion, which will start a new round of follicle growth and maturation. In the later stage of tr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/567A61K47/12A61K47/06A61K47/22A61P15/08
CPCA61K31/567A61K47/06A61K47/12A61K47/22A61P15/08
Inventor 包汝泼崔贞亮邵梦瑜
Owner NINGBO SANSHENG BIOLOGICAL TECH CO LTD
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