4 results about "Estrogen secretion" patented technology

The invention provides a strain of lactobacillus plantarum YS-AG23 with high antioxidant activity, and a rhizoma polygonati and radix angelicae sinensis fermented product obtained by fermenting rhizoma polygonati and radix angelicae sinensis with the strain of lactobacillus plantarum YS-AG23. In a D-galactose induced premature ovarian failure mouse model, the fermentation product can regulate up the levels of antioxidant and stress protection genes SOD2 and HO-1 and an anti-aging gene SIRT1 by regulating down the expression of a key gene AGER of an inflammation and oxidative stress pathway, so that the oxidative stress and inflammatory response of model mouse ovarian tissues are remarkably reduced; meanwhile, the serum hormone level can be specifically adjusted, the serum estradiol (E2) level can be increased, the follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels can be reduced to be close to the normal range, the expression of anti-mullerian hormone (AMH) and hormone regulatory gene LHR of ovarian reserve markers can be up-regulated, the proliferative activity and estrogen secretion function of follicular granulosa cells can be improved, and the effect of preventing ovarian reserve is achieved. The wet weight of atrophic uterus and ovary of the model mouse is remarkably increased, uterine and ovary atrophy is effectively reversed, and the ovarian reserve function of the D-galactose induced premature ovarian failure model mouse is recovered. Besides, in an H2O2-induced human dermal fibroblast aging model, the yeast can improve the activity of aging cells in a concentration-dependent manner and reduce the level of reactive oxygen species (ROS) in the cells; in addition, by up-regulating the expression of a collagen synthesis key gene COL1A1 and down-regulating the expression of a cell senescence marker gene p16, skin cell senescence caused by oxidative stress can be effectively improved. In conclusion, the polygonatum sibiricum and angelica sinensis leavening can synchronously improve premature ovarian failure and skin cell senescence caused by oxidative stress by accurately regulating and controlling oxidative stress, inflammatory response and tissue function related genes, and has wide application potential.

This invention discloses an Equoluxe multivitamin tablet containing a natural hormone regulator and its preparation process, belonging to the field of pharmaceutical technology. The invention comprises the following formula in parts by weight: 80-100 parts soybean extract, 20-55 parts plant-based lactic acid bacteria, 5-10 parts ginseng extract, 80 parts ginger extract, and 10-30 parts excipients. This invention, through a specific combination, works synergistically to promote estrogen secretion in women, enhance ovarian function, and maintain hormonal balance. By microencapsulating the plant-based lactic acid bacteria during pretreatment, this invention significantly improves the activity retention rate during tableting and storage, achieving an activity retention rate of over 87% after 6 months under accelerated conditions, thus solving the technical problem of poor stability in probiotic products. This invention employs a gradient mixing and low-temperature pressing process to avoid local aggregation of highly active ingredients and high-temperature inactivation, ensuring the uniformity of content and bioavailability of key components such as equoluxone and lactic acid bacteria in the tablets.

The invention discloses a gene for regulating chicken follicular cell proliferation and steroid hormone synthesis and application thereof, and belongs to the technical field of biotechnology and genetic breeding. Cell tests prove that the recombinant protein can improve the proliferation activity of chicken primary follicular membrane cells by 20-30%, increase the S-phase number by 14%, increase the proliferation number by 1.6 times, increase the estrogen secretion amount by 11% and increase the androgen secretion amount by 14% compared with a control group, and the recombinant protein can regulate and control the key links of follicular development. A new thought of cutting into a protein function is provided for poultry breeding; by detecting and selecting the IGFBP1 gene, the breeding efficiency of high-quality laying hens can be improved. Along with increase of breeding requirements of high-quality poultry varieties, the technology can shorten the breeding period of the new high-quality laying hen variety (commercial line), has wide application prospects, can assist in coping with related breeding challenges, improves breeding economic benefits, and provides support for innovation of a poultry genetic breeding technology.

The invention discloses an oral composition for improving female skin state and application thereof, the oral composition comprises ergothioneine and carob bean extract, the ergothioneine is used as a powerful endogenous antioxidant and provides direct oxidation defense for ovary and skin cells; and the carob bean extract accurately adjusts insulin sensitivity and hormone balance of the ovary through a core component DCI of the carob bean extract. According to the invention, the ergothioneine with strong anti-oxidation effect is combined with the carob bean extract which is good at metabolic regulation for the first time, and the combined product acts on the ovary-skin axis through the dual-channel synergistic effect of'anti-oxidation defense 'and'endocrine regulation'. Experiments show that the composition can synergistically improve estrogen secretion of ovarian granular cells and further promote skin collagen synthesis from inside to outside so as to shrink pores and inhibit melanin generation to brighten skin color, and the effect of the composition is remarkably superior to that of a single component.