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Use of total flavonoids of Houttuynia cordata in preparing medicine for preventing and treating viral pneumonia

A technology for viral pneumonia and total flavonoids, applied in the directions of antiviral agents, drug combinations, sugar derivatives preparation, etc., can solve problems such as reports on the efficacy of total flavonoids in Houttuynia cordata for viral pneumonia and drug research, etc. To achieve the effect of reducing lymphocyte infiltration, reducing permeability and inhibiting inflammatory response

Active Publication Date: 2019-02-01
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Throughout the research at home and abroad, there are no reports on the efficacy and drug research of total flavonoids of Houttuynia cordata in the treatment of viral pneumonia

Method used

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  • Use of total flavonoids of Houttuynia cordata in preparing medicine for preventing and treating viral pneumonia
  • Use of total flavonoids of Houttuynia cordata in preparing medicine for preventing and treating viral pneumonia
  • Use of total flavonoids of Houttuynia cordata in preparing medicine for preventing and treating viral pneumonia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: Preparation of total flavonoids of Houttuynia cordata

[0035] Take Houttuynia cordata medicinal material 100g, pulverize it, extract 3 times with 60%-90% ethanol under reflux in 80°C water bath, filter, collect the extract and concentrate to a small volume, add the concentrate dropwise on the upper layer of AB-8 macroporous adsorption resin column Let it stand overnight, wash the column with 10% ethanol and then elute with 70% ethanol, collect the eluate, concentrate and dry it into powder, and obtain the total flavonoids of Houttuynia cordata with a yield of more than 1.5%; using sodium nitrite-nitric acid The flavonoid content of total flavonoids in Houttuynia cordata was more than 75% as measured by aluminum method.

[0036] Table 1 is the yield and content of total flavonoids in Houttuynia cordata

[0037]

Embodiment 2

[0038] Example 2: In vivo efficacy evaluation of total flavonoids of Houttuynia cordata

[0039] Thirty Balb / c mice (15-16g) were randomly divided into 4 groups (A, B, C, D, E) according to body weight: Group A was the normal control group, Group B was the H1N1 virus model group, and Group C was the H1N1 virus model group. Total flavonoids of Houttuynia cordata (100mg / kg), group D is total flavonoids of Houttuynia cordata (200mg / kg), E is positive drug ribavirin group, 6 animals in each group, animals in all groups are anesthetized by propofol tail vein , intranasal infection 3LD 5030ul of H1N1 virus liquid, 30ul of 1640 culture medium infected by intranasal drops in group A was used as a control; groups B, C, D, and E were infected with H1N1 dilution, and groups C and D were administered intragastrically 2 hours after infection with total flavonoids of Houttuynia cordata at a dose of 100mg / kg, 200mg / kg; groups A and B were given 0.5% CMC by intragastric administration, as no...

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Abstract

The invention belongs to the field of traditional Chinese medicine, and relates to use of total flavonoids of Houttuynia cordata in preparing a medicine for preventing and treating viral pneumonia. The product yield of a total flavonoid extract extracted from the traditional Chinese medicine Houttuynia cordata is 1.5% or more, the flavonoid content is 75% or more, and main flavonoid components include quercitrin, hyperoside, isoquercitrin, rutin, and the like. The significant therapeutic effect of the total flavonoids of Houttuynia cordata on influenza a virus H1N1-induced mouse viral pneumonia is confirmed by whole animal experiments, the total flavonoids of Houttuynia cordata reduce the capillary permeability of the lung, reduce pulmonary edema, inhibit inflammatory reactions in the whole body and local inflammatory reactions in the lung, thereby reducing acute lung injury. The total flavonoids of Houttuynia cordata can be further used for preparing the medicine for preventing and treating viral pneumonia.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a new medicinal use of total flavonoids of Houttuynia cordata, a traditional Chinese medicine, in particular to the use of total flavonoids of Houttuynia cordata in preparing medicines for preventing and treating viral pneumonia. Background technique [0002] It is reported in the prior art that viral pneumonia (viral pneumonia) is lung inflammation caused by a variety of viral infections, usually caused by the downward spread of upper respiratory tract viral infection. Studies have shown that influenza virus is the most common virus that causes viral pneumonia, and also includes parainfluenza virus, cytomegalovirus, adenovirus, rhinovirus, coronavirus and some enteroviruses. Influenza A virus is an important pathogen causing respiratory diseases in humans and birds. Influenza virus invades the bronchiolar epithelium and causes bronchiolitis, and the infection spreads ...

Claims

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Application Information

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IPC IPC(8): A61K36/78A61P11/00A61P31/16C07H17/07C07H1/08A61K31/7048C07D311/30C07D311/40A61K31/352
CPCA61K31/352A61K31/7048A61K36/78A61K2236/333A61K2236/51A61K2236/55C07D311/30C07D311/40C07H1/08C07H17/07A61K2300/00
Inventor 陈道峰凌丽君卢燕力弘章蕴毅朱海燕
Owner FUDAN UNIV
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