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Application of aqueous acrostichumaureum extract to preparation of medicines for treating acute gastric ulcer

A water extract, gastric ulcer technology, applied in the field of drugs with undetermined structure, can solve the problems of obvious side effects, high price, etc., to restore integrity, repair histopathological changes, reduce gastric inflammatory reaction and mucosal damage Effect

Inactive Publication Date: 2019-02-15
GUANGDONG ACAD OF FORESTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned drugs have a certain protective effect on gastric ulcer, they have the disadvantages of obvious side effects and high price.

Method used

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  • Application of aqueous acrostichumaureum extract to preparation of medicines for treating acute gastric ulcer
  • Application of aqueous acrostichumaureum extract to preparation of medicines for treating acute gastric ulcer
  • Application of aqueous acrostichumaureum extract to preparation of medicines for treating acute gastric ulcer

Examples

Experimental program
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preparation example Construction

[0027] 2.1 Preparation of water-extracted extract powder of Brine fern

[0028] The water extraction method can extract most of the active ingredients in the plant, so the water extraction method is used to extract the active ingredients of the fern. The specific process is as follows: take 6.28 kg of the dried aboveground part of the fern, cut it into small pieces, add 10 times of water to soak, extract twice by decocting for 2 hours each time, and filter to obtain the extract. The extracts are combined, heated and evaporated to remove a large amount of water, and then freeze-dried in a vacuum to obtain water-extracted extract powder.

[0029] 2.2 Effects on the rat model of acute gastric ulcer induced by absolute ethanol

[0030] Get SPF grade male Wistar rats before experiment begins, weigh, be divided into normal group (Normal) at random by body weight, model group (Model), lansoprazole group (LSZ, 30mg / kg), brine fern aqueous extract ( WEAC) low, medium and high dose gr...

example 1

[0057] Example 1 (oral solution)

[0058] Take by weighing 100g bittern fern water extract extract powder, add solubilizing agent Tween 80, and a certain proportion of ethanol, fully stir; Then add suitable additives such as stevioside, potassium sorbate (as flavoring agent, bacteriostat, Antioxidant, coloring agent), dissolve evenly, filter and clarify, put the contents into oral liquid glass bottles, and sterilize. The specification is 400mg per bottle of oral solution containing fern fern, and the net content of each bottle is 10mL. Oral, for the treatment of acute gastric ulcer. Symptoms: upper abdominal discomfort, pain, severe abdominal cramps, anorexia, nausea, vomiting, diarrhea, etc.

example 2

[0059] Example 2 (oral solution)

[0060] Take by weighing 100g bittern fern water extract extract powder, add solubilizer Tween 80, and a certain proportion of ethanol, fully stir; Then add suitable additives such as stevioside, benzoic acid (as flavoring agent, antibacterial agent, antibacterial agent, etc.) oxidizing agent, coloring agent), dissolve evenly, filter and clarify, put the content into a glass bottle of oral liquid, and sterilize. The specification is 400mg per bottle of oral solution containing fern fern, and the net content of each bottle is 10mL. Oral, for the treatment of acute gastric ulcer. Symptoms: upper abdominal discomfort, pain, severe abdominal cramps, anorexia, nausea, vomiting, diarrhea, etc.

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Abstract

The invention relates to application of an aqueous acrostichumaureum extract to preparation of medicines for treating acute gastric ulcer. In the application, the aqueous acrostichumaureum extract cansignificantly reduce the gastric ulcer area and a pathological score of a model rat, restore gastric mucosal integrity, repair histopathological change and reduce gastric inflammatory reaction and mucosal injury, so that the aqueous acrostichumaureum extract can be prepared into clinically common oral preparations.

Description

technical field [0001] The present invention relates to a drug with undetermined structure from a plant of the genus Halogenaceae, in particular to a drug for treating alimentary canal or digestive system diseases. Background technique [0002] Gastric ulcer (Gastric ulcer) is a common digestive disease, which recurs and greatly affects the quality of life of patients. Bleeding and perforation are the first symptoms of gastric ulcer, and patients will experience dull pain, distending pain, and burning pain in the abdomen. In recent years, with the rapid development of my country's social economy, people's eating habits have changed accordingly, and the incidence of gastric ulcer has gradually increased. Gastric ulcer is a worldwide disease. About 10% of the global population has suffered from gastric ulcer, and 1% of the ulcer can be transformed into gastric cancer. Therefore, this disease is listed as a precancerous disease by the World Health Organization. It is quite ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/12A61P1/04
CPCA61K36/12A61K2236/331A61K2236/39A61K2236/51A61P1/04
Inventor 蔡坚张谦高常军吴雪苏子仁刘煜洪
Owner GUANGDONG ACAD OF FORESTRY
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