Application of phloretin to preparation of colitis preventing and treating drug
A technology of colitis and phloretin, which is applied in the field of application of phloretin in the preparation of drugs for the prevention and treatment of colitis, and can solve the problems that glucocorticoids are easy to cause obesity, patients are difficult to maintain long-term treatment, and adverse reactions are prone to occur , to achieve no adverse reactions and side effects, improve the pathological damage of colonic tissue, and reduce the effect of disease activity index
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[0017] In order to make the objectives, technical solutions, and advantages of the present invention clearer, the following embodiments will further describe the present invention in detail. It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention.
[0018] Phloretin (Phloretin) belongs to the dihydrochalcone compound. It is a natural active substance present in the root bark of juicy fruits such as apples and pears. The structural formula of the phloretin monomer of the present invention is as follows:
[0019]
[0020] The present invention verifies the preventive and therapeutic effects of phloretin on ulcerative colitis through two sets of experiments. The specific experimental plan is as follows:
[0021] The first part of the experimental program: the preventive effect of phloretin on ulcerative colitis
[0022] In the present invention, an animal model of ulcerative colitis indu...
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