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Application of phloretin to preparation of colitis preventing and treating drug

A technology of colitis and phloretin, which is applied in the field of application of phloretin in the preparation of drugs for the prevention and treatment of colitis, and can solve the problems that glucocorticoids are easy to cause obesity, patients are difficult to maintain long-term treatment, and adverse reactions are prone to occur , to achieve no adverse reactions and side effects, improve the pathological damage of colonic tissue, and reduce the effect of disease activity index

Inactive Publication Date: 2019-02-22
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] above, but the incidence of adverse reactions such as nausea, vomiting, headache, and loss of appetite is relatively high; (2) glucocorticoids are the most effective for inhibiting acute active inflammation in UC, but they have no maintenance effect, and glucocorticoids are likely to cause obesity. The price is high, and it is difficult for patients to maintain treatment for a long time; (3) Immunosuppressants are prone to adverse reactions, and some patients do not respond to existing drugs, so their practical application has certain limitations

Method used

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  • Application of phloretin to preparation of colitis preventing and treating drug
  • Application of phloretin to preparation of colitis preventing and treating drug
  • Application of phloretin to preparation of colitis preventing and treating drug

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Embodiment Construction

[0017] In order to make the object, technical solution and advantages of the present invention clearer, the following examples further describe the present invention in detail. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0018] Phloretin (Phloretin) belongs to dihydrochalcone compound, is the natural active substance existing in the root bark of juicy fruits such as apple, pear, and the structural formula of phloretin monomer of the present invention is as follows:

[0019]

[0020] The present invention respectively verifies the preventive effect and the therapeutic effect of phloretin on ulcerative colitis by two groups of experiments, and the experimental scheme is specifically as follows:

[0021] The first part of the experimental protocol: the preventive effect of phloretin on ulcerative colitis

[0022] The present invention establishes an animal model of u...

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Abstract

The invention discloses an application of phloretin to preparation of an ulcerative colitis preventing and treating drug. According to the application of phloretin to the ulcerative colitis preventingand treating drug, the phloretin can prevent and treat ulcerative colitis, has no adverse reactions or side effects and has a maintained effect.

Description

technical field [0001] The invention relates to the field of biopharmaceuticals, in particular to the application of phloretin in the preparation of drugs for preventing and treating colitis. Background technique [0002] Ulcerative colitis (UC) is a chronic non-specific intestinal disease of unknown cause. The lesions are mainly located in the mucosal layer of the colon, often involving the rectum and distal colon, and can also spread throughout the colon, showing continuous diffusion. sex distribution. The disease is seen at any age, and is more common in the age of 25-40. Except for a few patients with sudden onset, most patients have a slow onset, and the severity of the disease varies. Abdominal pain, diarrhea, mucus and bloody stools, and tenesmus were the main clinical symptoms. Histopathological manifestations were submucosal edema, inflammatory cell infiltration, decreased goblet cells, and decreased number of crypts. Endoscopic colon showed erosions, ulcers, and o...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61P1/00A61P1/04
CPCA61K31/12A61P1/00A61P1/04
Inventor 吴敏娜李璞泽钟根深闫冬李敏
Owner XINXIANG MEDICAL UNIV
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