Water-soluble florfenicol effervescent agent and preparation method thereof

A technology of florfenicol and effervescent agent, which is applied in the field of florfenicol effervescent agent and its preparation, can solve the problems of slow dissolution rate, inconvenient use, unsatisfactory solubilizing effect, etc., and achieve low production cost, The production energy consumption is small, which is conducive to the effect of large-scale production and promotion

Inactive Publication Date: 2019-03-05
王小桥
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problem of unsatisfactory solubilizing effect of the existing solubilizing method, slow dissolving speed and inconvenient use, and provide a water-soluble florfenicol effervescent agent and a preparation method thereof

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A kind of preparation steps of water-soluble Florfenicol effervescent agent:

[0022] (1), produce 100kg of ultrafine powdered florfenicol, called ultrafine powdered florfenicol 20kg, sodium lauryl sulfate 0.2kg and anhydrous glucose 26.8kg, pour into a mixer, and mix well;

[0023] (2), pour the mixture of (1) into a pulverizer, pulverize and sieve 120;

[0024] (3) Mix 10kg of anhydrous sodium carbonate and 3kg of citric acid evenly, and coat with polyethylene glycol 4000 40kg;

[0025] (4) Pour (2) and (3) into a mixer and mix evenly, and directly compress into tablets to obtain.

Embodiment 2

[0027] A kind of preparation steps of water-soluble Florfenicol effervescent agent:

[0028] (1) Produce 100kg of ultrafine florfenicol, called ultrafine florfenicol 20kg, poloxamer 0.2kg and anhydrous glucose 26kg, pour into a mixer, and mix well;

[0029] (2), pour the mixture of (1) into a pulverizer, pulverize and sieve 120;

[0030] (3) Mix 10kg of anhydrous sodium carbonate and 3kg of citric acid evenly, and coat with polyethylene glycol 4000 40kg;

[0031] (4) Pour (2) and (3) into a mixer and mix evenly, and directly compress into tablets to obtain.

Embodiment 3

[0033] A kind of preparation steps of water-soluble Florfenicol effervescent agent:

[0034] (1) Produce 100kg of ultrafine powdered florfenicol, called ultrafine powdered florfenicol 20kg, polyvinylpyrrolidone K 30 1kg and 26.8kg of anhydrous glucose, pour into the mixer and mix evenly;

[0035] (2), pour the mixture of (1) into a pulverizer, pulverize and sieve 120;

[0036] (3) Mix 10kg of anhydrous sodium carbonate and 3kg of citric acid evenly, and coat with polyethylene glycol 4000 40kg;

[0037] (4) Pour (2) and (3) into a mixer and mix evenly, and directly compress into tablets to obtain.

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Abstract

The invention relates to the field of veterinary antibiotics, and discloses a water-soluble florfenicol effervescent agent and a preparation method thereof. The florfenicol effervescent agent includes, by weight, 1-20 parts of ultrafine florfenicol powder, 0.2-5 parts of a cosolvent, 3-5 parts of an organic acid (an acid agent), and 1-11 parts of inorganic salt (an alkaline agent), with the balance being a filler and the total being 100 parts. Raw and auxiliary ingredients are safe, easily available and cheap, the process is simple, and the method has advantages of strong operability, low production cost, short preparation time and low production energy consumption, and is suitable for large-scale production and promotion.

Description

technical field [0001] The invention relates to the field of veterinary drug antibiotics, in particular to a water-soluble florfenicol effervescent agent and a preparation method thereof. Background technique [0002] Florfenicol (Florfenicol) Chinese name: fluprofen, florfenicol, florfenicol, is a new veterinary-specific broad-spectrum antibacterial drug of chloramphenicol successfully developed in the late 1980s. It has the characteristics of wide antibacterial spectrum, good absorption, wide distribution in the body, high efficiency and safety, etc. It has a significant therapeutic effect on poultry bacterial diseases caused by sensitive bacteria, and has effects on both Gram-positive and Gram-negative bacteria. The drug of choice for various infections caused by Bacillus and Salmonella. It was first launched in Japan in 1990. In 1993, Norway approved the drug to treat salmon furunculosis. In 1995, France, the United Kingdom, Austria, Mexico and Spain approved it to trea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/46A61K31/165A61P31/04
CPCA61K31/165A61K9/0007A61K9/2031
Inventor 王小桥王存亮伍重远熊玲玲
Owner 王小桥
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