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A preparation method of baicalein drug-loaded nanorods

A technology of drug-loading nanometer and baicalein, which is applied in nanotechnology, pharmaceutical formulations, nanotechnology and other directions to achieve good effects, reduce toxic and side effects, and increase contact time and contact area.

Active Publication Date: 2021-02-23
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The oral toxicity of baicalein is extremely low, but its intravenous injection is much more toxic than oral gavage

Method used

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  • A preparation method of baicalein drug-loaded nanorods
  • A preparation method of baicalein drug-loaded nanorods

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Embodiment 1

[0017] 1. Test plan

[0018] A preparation method of baicalein drug-loaded nanorods, comprising the following steps:

[0019] (1) Weigh 7.957g of sodium dihydrogen phosphate and 17.549g of disodium hydrogen phosphate powder, respectively dissolve them in appropriate amount of distilled water, then transfer them to a 500ml volumetric flask, dilute with distilled water to 500mL, and obtain the pH value Phosphate buffer solution of 6.7;

[0020] (2) Accurately weigh 0.01g baicalein and 0.10g pectin and add them to a 50mL volumetric flask, add a magnet, then add 20mL of PBS solution with a pH of 6.7, then immerse in a constant temperature water bath at 50°C, stir magnetically, and heat 0.5 hours; preparation of Ca(OH) 2 solution (0.02mol / L), add 8mL dropwise to the above solution, and stir at 50°C for 1 hour; then, NaHCO 3 8 mL of the solution (0.03 mol / L) was added dropwise to the above reaction system, stirred at 50° C. for another 3 hours, and then 0.010 g of baicalein was a...

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Abstract

The invention relates to a preparation method of baicalein drug-loaded nanorods, which belongs to the field of pharmacy. The method comprises the following steps: firstly weigh baicalein and pectin respectively and add them to a glass container, then add a phosphate buffer solution, and put the glass container Immerse in a constant temperature water bath at 50°C, stir and mix evenly with a magnetic force to obtain a mixed solution I; then add a Ca(OH)₂ aqueous solution to the mixed solution I dropwise, and heat at 50°C for 1 hour; then add a NaHCO₃ aqueous solution dropwise, Heating at 50°C for another 3 hours to obtain the mixed solution II; finally, add baicalein to the mixed solution II, continue magnetic stirring at 50°C for 24 hours, put it into a dialysis bag after cooling, and in the phosphate buffer solution at 20°C The baicalein-loaded nanorods were obtained by dialysis for 24 hours. The baicalein drug-loaded nanorods prepared by the preparation method exhibit good targeting, tissue compatibility, low toxicity and side effects and sustained release function.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a preparation method of baicalein drug-loaded nanorods. Background technique [0002] The nano drug-carrying system refers to a complete system in which the prepared nano-structure particle size is between 1 and 1000 nm, and the drug is encapsulated, dispersed, and adsorbed in the polymer. Flavonoids refer to a general term for a class of compounds with a chromone ring and a benzene ring as the basic structure. They are derivatives of chromone or chromane, derived from flavone (2-phenylchromone) as the mother nucleus. A class of yellow pigments. Nano-loaded drug system is a new drug delivery form. The size of drug-loaded nanoparticles is similar to that of body proteins. It can easily penetrate the cell membrane and enter the interstitial fluid without being rejected by the body. It has good tissue compatibility. By encapsulating the drug to achieve sustained release and sta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K9/52A61K31/352A61K47/36A61P1/16A61P7/10A61P29/00A61P31/04A61P31/12A61P35/00B82Y5/00
CPCA61K9/146A61K9/5161A61K31/352A61P1/16A61P7/10A61P29/00A61P31/04A61P31/12A61P35/00B82Y5/00
Inventor 梁菊吴文澜梁园李军波周惠云
Owner HENAN UNIV OF SCI & TECH
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