Fowlpox heat-resistant freeze-drying protective agent and application thereof

Abstract

The invention discloses a fowlpox heat-resistant freeze-drying protective agent and application thereof and belongs to the field of preparation and application of heat-resistant freeze-drying protective agents. The invention firstly discloses the fowlpox heat-resistant freeze-drying protective agent. The fowlpox heat-resistant freeze-drying protective agent comprises the following components: mycose, mannitol, polypeptone and purified water. The fowlpox heat-resistant freeze-drying protective agent, disclosed by the invention, has the advantages that the formula is simple, resources are effectively saved and the fowlpox heat-resistant freeze-drying protective agent is more suitable for large-scale production. The invention further discloses application of the fowlpox heat-resistant freeze-drying protective agent to preparation of a fowlpox heat-resistant protective agent live vaccine. The fowlpox heat-resistant freeze-drying protective agent, disclosed by the invention, has the advantages that a freeze-drying curve in vaccine preparation is optimized so that the freeze-drying time is shortened to 24 hours; and moreover, the effect of the prepared vaccine is high. The prepared fowlpox heat-resistant protective agent live vaccine has the advantages that the effect is high, the vaccine can be preserved for 36 months at a temperature of 2-8 degrees centigrade, the dropping titer isless after heat resisting, and the effect of the vaccine is more stable.

Description

technical field [0001] The invention relates to a heat-resistant freeze-drying protectant for fowl pox, and also relates to the application of the heat-resistant freeze-dry protectant for fowl pox in the preparation of a live vaccine of the heat-resistant freeze-dry protectant for fowl pox, belonging to the heat-resistant freeze-dry protectant for fowl pox Preparation and application fields. Background technique [0002] China's research on heat-resistant freeze-drying protective agents started relatively late, but now the research in this area has achieved certain results, and a heat-resistant freeze-drying protective agent for chickenpox has been developed. Parts are usually: gelatin 3%, lactose 5-6%, EDTA 2%, PVP (K90) 5%, sorbitol 2%, sodium glutamate 1%, beef peptone 2%, bovine serum albumin 1%, Vc 0.1%; the preparation is the dry matter component, and the rest of the percentage is distilled water. The effective components of the autoclavable and high-temperature-resi...

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Problems solved by technology

[0003] In view of the shortcomings of the above processes such as complex formula and long freeze-drying time, the formula and freeze-drying curve of heat-resistant freeze-drying protective agent are improved to make the formula simpler and shorten the freeze-drying time, which not only saves resources, but also is more suitable for large-scale production

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