Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Injection grade ovateleaf holly bark extract and preparation method thereof, and compound ovateleaf holly bark injection as well as preparation method and application thereof

A technology of saving Bing and extracts, which is applied in the field of compound Jiao Bing injection and its preparation, injection-grade Jiao Bing extract and its preparation, can solve the problems of doubtful quality control ability, large environmental hazards, large side effects and the like, Achieve the effect of being conducive to safe production and environmental friendliness, with low physical harm and easy operation.

Inactive Publication Date: 2019-03-08
QINGDAO VLAND BIOTECH INC +1
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has the following deficiencies: 1. directly extract with ethanol, the extraction is incomplete, and causes the waste of medicinal materials
②The degree of post-treatment is not enough, resulting in more impurities in the obtained extract, unclear components, unclear pharmacological reactions, and large side effects
This method has the following deficiencies: 1. the ethanol content is not specified in the preparation process
②The products produced by its process did not explain the quality control method, and its quality control ability is doubtful
③ Ultrasonic extraction is used, and the cost of the extract produced by it is relatively high, and it is not conducive to the protection of laborers
Traditional chemical drug injections have the risks of easy drug resistance, high residue, great environmental hazards, and easy abuse

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Injection grade ovateleaf holly bark extract and preparation method thereof, and compound ovateleaf holly bark injection as well as preparation method and application thereof
  • Injection grade ovateleaf holly bark extract and preparation method thereof, and compound ovateleaf holly bark injection as well as preparation method and application thereof
  • Injection grade ovateleaf holly bark extract and preparation method thereof, and compound ovateleaf holly bark injection as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1: the preparation method of injection-grade rescue must extract

[0052] The embodiment of the present invention provides a preparation method of injection-grade jiubing extract, comprising the following steps:

[0053] Step 1. Select the raw material of jiubing, select and remove the impurities, crush and pass through a 4-mesh sieve to make jiubing coarse powder;

[0054] Step 2: Take 2000g of Bing coarse powder, add 5 times the volume of water of the weight of Bing coarse powder, add acid to adjust the pH value to 6, add 1% of the weight of Bing coarse powder, fully stir, set Keep warm at 45°C for 5 hours;

[0055] Step 3, add ethanol again to make the ethanol content 90%, heat and reflux for extraction 3 times, filter and then combine the filtrates;

[0056] Step 4. Recover the ethanol from the filtrate obtained in step 3 until it has no alcohol smell, filter it, take the filtrate, add 3 times the volume of n-butanol, mix and extract 3 times, combine th...

Embodiment 2

[0058] Embodiment 2: the preparation method of injection grade rescue must be extract

[0059] The embodiment of the present invention provides a preparation method of injection-grade jiubing extract, comprising the following steps:

[0060] Step 1. Select the raw materials of jiubing, select and remove impurities, and crush them through a 6-mesh sieve to make jiubing coarse powder;

[0061] Step 2: Take 2000g of Bing coarse powder, add 4 times the volume of water of the weight of Bing coarse powder, add acid to adjust the pH value to 5, add 0.6% of the weight of Bing coarse powder, fully stir, set 40°C for 4 hours;

[0062] Step 3, add ethanol again to make the ethanol content 80%, heat and reflux for extraction 3 times, filter and then combine the filtrates;

[0063] Step 4. Recover the ethanol from the filtrate obtained in step 3 until it has no alcohol smell, filter it, take the filtrate, add 2 times the volume of n-butanol, mix and extract 3 times, combine the n-butanol...

Embodiment 3

[0065] Embodiment 3: the preparation method of injection grade rescue must extract

[0066] The embodiment of the present invention provides a preparation method of injection-grade jiubing extract, comprising the following steps:

[0067] Step 1. Select the raw materials of jiubing, select and remove impurities, and crush them through an 8-mesh sieve to make jiubing coarse powder;

[0068] Step 2: Take 2000g of Bing coarse powder, add water 4 times the weight of Bing coarse powder, add acid to adjust the pH value to 5, add 0.4% of the weight of Bing coarse powder, fully stir, set 40°C for 3 hours;

[0069] Step 3, add ethanol again to make the ethanol content 70%, heat and reflux for extraction 3 times, filter and then combine the filtrates;

[0070] Step 4. Recover the ethanol from the filtrate obtained in step 3 until it has no alcohol smell, filter it, take the filtrate, add 3 times the volume of n-butanol, mix and extract twice, combine the n-butanol solution and add an ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an injection grade ovateleaf holly bark extract and a preparation method thereof, and a compound holly bark injection as well as a preparation method and the application thereof, and belongs to the field of traditional Chinese medicinal extracts and application. The preparation method of the injection grade ovateleaf holly bark extract is characterized by comprising the following steps: selecting a ovateleaf holly bark raw material and crushing into an ovateleaf holly bark crude powder; taking the ovateleaf holly bark crude powder, adding water for soaking, adjusting the pH value and adding enzyme for insulating; then adding ethanol, carrying out heating reflux extraction and filtering; recovering the ethanol from filtrate and filtering; taking the filtrate and adding n-butanol for extraction, taking a n-butanol liquid, adding water for shaking, discarding a water layer and recovering the n-butanol to obtain concentrate; adding methanol into the concentrate fordissolving, adding ether for precipitation, filtering and taking precipitate for drying to obtain the injection grade ovateleaf holly bark extract. The injection grade ovateleaf holly bark extract disclosed by the invention has the beneficial effects that the contents of syringin and pedunculoside are high; the compound holly bark injection disclosed by the invention has good effects in the application of treating yellow and white scour of piglets.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine extracts and applications, in particular to an injection-grade jiubing extract and a preparation method thereof, a compound jiubing injection, a preparation method and applications thereof. Background technique [0002] Jiubingying is derived from the bark (split bark) or root bark of Ilex rotunda Thunb, the genus of Ilex in the Ilex family. The leaves and roots can also be used as medicine. Also known as sheep do not eat, nine layers of skin, Holly Aberdeen, mountain holly, etc. It is widely distributed in Yunnan, Guangxi, Guangdong, Fujian, Taiwan and other places in my country. It is a herbal medicine widely used by folks in South China. Its nature and taste are bitter and cold. Return lung; Liver; Large intestine channel. It has the effects of clearing away heat and detoxification, promoting dampness, reducing swelling and relieving pain. [0003] At present, there are few resear...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/185A61K9/08A61K9/19A61P1/12A61P31/04A61K31/43A61K31/424
CPCA61K9/0019A61K9/08A61K9/19A61K31/424A61K31/43A61K36/185A61K2236/19A61K2236/331A61K2236/333A61K2236/39A61P1/12A61P31/04A61K2300/00
Inventor 庞云露王艳玲孙亚磊蒋贻海刘元元武利利栾明娜张会梅钟英杰袁延文
Owner QINGDAO VLAND BIOTECH INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com