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A traditional Chinese medicine composition for treating Alzheimer's disease and its preparation method and application

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition for the treatment of Alzheimer's disease and its preparation, can solve problems such as liver and kidney toxicity, reduced therapeutic effect, and large side effects, and achieve inhibition of nerve cell apoptosis and improvement Spatial learning ability and spatial exploration ability, effect of reducing cell damage

Active Publication Date: 2021-06-08
吉林修正药业新药开发有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, Western medicine is the main treatment for Alzheimer's disease, such as estrogen, which inhibits the formation of Aβ protein, indomethacin, an anti-inflammatory drug, and tacrine, a drug that acts on the cholinergic nervous system. , but the effect is single and the side effects are large. With the prolongation of the treatment time, the therapeutic effect tends to decrease, and long-term use can also cause liver and kidney toxicity. , a traditional Chinese medicine preparation that effectively prevents and treats Alzheimer's disease

Method used

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  • A traditional Chinese medicine composition for treating Alzheimer's disease and its preparation method and application
  • A traditional Chinese medicine composition for treating Alzheimer's disease and its preparation method and application
  • A traditional Chinese medicine composition for treating Alzheimer's disease and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 Composition of the present invention

[0040] Prescription: Rehmannia glutinosa 150g, yam 100g, Poria cocos 130g, dogwood 150g, Alisma 130g, Moutan cortex 100g, cinnamon 30g, epimedium 150g, calamus 80g by weight, cumin 50g.

[0041] Preparation:

[0042] (1) Take the above-mentioned Rehmannia glutinosa, Chinese yam, Poria cocos, Cornus officinalis and Alisma alisma and grind them into fine powder, set aside;

[0043] (2) Take the above Moutan cortex and add 15 times the quality of water, extract by steam distillation for 5 hours, filter, add 1mol / L hydrochloric acid solution to the filtrate, precipitate crystals, filter, wash the crystals with water, dry at low temperature, and pulverize into fine powder ,spare;

[0044] (3) Get above-mentioned cassia cinnamon, epimedium, calamus calamus, fennel and add 10 times the quality of water, extract by steam distillation for 4 hours, and collect volatile oil;

[0045] (4) Dissolve the volatile oil with an equal...

Embodiment 2

[0047]Embodiment 2 compositions of the present invention

[0048] Prescription: Rehmannia glutinosa 100g, yam 80g, Poria cocos 100g, dogwood 100g, Alisma 100g, Moutan cortex 80g, cinnamon 50g, epimedium 200g, calamus 100g by weight, cumin 100g.

[0049] Preparation:

[0050] (1) Take the above-mentioned Rehmannia glutinosa, Chinese yam, Poria cocos, Cornus officinalis and Alisma alisma and grind them into fine powder, set aside;

[0051] (2) Take above Moutan bark and add 12 times of water, extract by steam distillation for 6 hours, filter, add 1mol / L hydrochloric acid solution to the filtrate, precipitate crystals, filter, wash the crystals with water, dry at low temperature, pulverize into fine powder, and set aside ;

[0052] (3) Get above-mentioned cassia cinnamon, epimedium, calamus calamus, fennel and add 12 times the water of quality, extract by steam distillation for 5 hours, collect volatile oil;

[0053] (4) Dissolve the volatile oil with an equal volume of absolu...

Embodiment 3

[0055] Embodiment 3 compositions of the present invention

[0056] Prescription: Rehmannia glutinosa 200g, Chinese yam 150g, Poria cocos 130g, Cornus officinalis 130g, Alisma 130g, Moutan cortex 50g, cinnamon 40g, Epimedium 100g, Shichangpu 50g by weight, cumin 80g.

[0057] Preparation:

[0058] (1) Take the above-mentioned Rehmannia glutinosa, Chinese yam, Poria cocos, Cornus officinalis and Alisma alisma and grind them into fine powder, set aside;

[0059] (2) Take the above Moutan cortex and add 10 times the quality of water, extract by steam distillation for 5 hours, filter, add 1mol / L hydrochloric acid solution to the filtrate, precipitate crystals, filter, wash the crystals with water, dry at low temperature, and pulverize into fine powder ,spare;

[0060] (3) Get above-mentioned cassia cinnamon, epimedium, calamus calamus, fennel and add 10 times the quality of water, extract by steam distillation for 4 hours, and collect volatile oil;

[0061] (4) Dissolve the vola...

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Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating Alzheimer's disease, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from Rehmannia glutinosa, Chinese yam, Poria cocos, Cornus officinalis, Alisma, Cortex Moutan, cinnamon, epimedium, calamus calamus and fennel. The composition provided by the invention, through reasonable compatibility, makes each component produce a synergistic effect, and has remarkable curative effect on Alzheimer's disease. Experimental results show that the traditional Chinese medicine composition provided by the present invention can reduce SH-SY5Y cell damage caused by low sugar and hypoxia, improve the spatial learning ability and spatial exploration ability of Alzheimer's disease rats, and reduce the content of acetylcholinesterase AchE in brain tissue , inhibit the apoptosis of nerve cells in the CAI area, and have a significant therapeutic effect on Alzheimer's disease.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating Alzheimer's disease, a preparation method and application thereof. Background technique [0002] Alzheimer's disease (Alzheimer's disease, AD) is a degenerative disease of the central nervous system, which is related to age and mostly occurs in the elderly. There are many hypotheses about the pathogenesis of AD, such as inflammatory response, amyloid (Aβ) deposition, abnormal phosphorylation of tau protein, cholinergic hypothesis, oxidative stress response and apoptosis theory, etc. Among them, the β-amyloid theory is recognized by researchers. The theory holds that β-amyloid (Aβ) is cleaved from β-amyloid precursor protein (APP) by β-secretase (β-secretase) and γ-secretase (γ-secretase) After that, the deposition of Aβ will trigger a series of effects such as neurotoxicity, oxidative damag...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61K47/69A61P25/28
CPCA61K36/076A61K36/235A61K36/296A61K36/40A61K36/54A61K36/65A61K36/71A61K36/804A61K36/884A61K36/888A61K36/8945A61K2236/331A61K47/6951A61P25/28A61K2300/00
Inventor 石菊徐云徐建许艳茹王鑫宫海泉
Owner 吉林修正药业新药开发有限公司
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