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Composition including tectorigenin and tectorigenin glucoside

A technology of irisin glucoside and irisin glucoside, which is applied in the field of compositions containing irisin and irisin glucoside, can solve problems that are not yet clear, and achieve excellent effects, improve skin elasticity, and improve liver function. Effect

Pending Publication Date: 2019-03-29
TOYO SHINYAKU KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since irisaxanthins are contained in plants, they are considered to be relatively safe and easy to take in daily, but there are many things that are not clear about their activity or function

Method used

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  • Composition including tectorigenin and tectorigenin glucoside
  • Composition including tectorigenin and tectorigenin glucoside
  • Composition including tectorigenin and tectorigenin glucoside

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] [Example 1] As the test substance of Example 1, the mass ratio used is irisgenin (TGE): irisgenin glycoside=1:21 (the detailed composition of the glycoside is TD in mass ratio: TGXG=1:1.9 ) powdered composition. These were used for the muscle differentiation test in the order of (1) to (3) below, and the bone differentiation test in the order of (I) to (V) below, respectively.

[0077] (Muscle differentiation test) (1) Myoblast C2C12 derived from mouse striated muscle (obtained from RIKEN) was used in DMEM (Dulbecco's minimum essential medium, Dulbecco's minimum essential medium) containing 10% FBS (Fetal bovine serum, fetal bovine serum). Minimal Essential Medium) in 5 vol% CO 2 Culture was carried out in an incubator at 37° C. under humid conditions until reaching a specific number. Next, the medium was removed, and after washing three times with DPBS (Dulbecco's phosphate buffered saline, Dulbecco's phosphate buffered saline), the cells were detached with trypsin-e...

Embodiment 4

[0098] [Example 4] As the test substance of Example 4, 43.14 mg of a powder composition (the total amount of TGE and TGE glycoside) with a mass ratio of TGE: TGE glycoside = 1: 22.19 (TD: TGXG = 1: 1.81) was used. ). This was subjected to the cosmetic test described below.

[0099] (Cosmetic test) Two healthy and normal females (mean age 19.7 years old) were used as test subjects. The subjects were asked to ingest the test substance of Example 4 dissolved in water every morning. Continue it for 12 weeks. Before ingestion started, after ingestion started (after 4, 8, and 12 weeks), the stratum corneum moisture content and moisture evaporation of the left cheek (near the center when connecting the outer corner of the eye and the nose wing with a straight line) were measured with the following measuring device , elastic. The average value of the moisture content of the stratum corneum is shown in Figure 5 , the average value of water evapotranspiration is shown in Figure ...

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PUM

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Abstract

The invention provides a composition, which has excellent effect of improving tissue differentiation or improving body fat decomposition, improving skin texture, and improving liver function. The composition preferably includes tectorigenin and tectorigenin glucoside with mass ratio of higher than 1:10; and preferably, the tectorigenin glucoside includes a glucoside formed by bonding one saccharide onto tectorigenin and a glucoside formed by bonding two saccharides onto tectorigenin, wherein the mass ratio of the former to the latter is more than 1:0.01 and lower than 1:7.5; more preferably, the glucoside formed by bonding one saccharide onto tectorigenin is tectoridin, and the glucoside formed by bonding two saccharides onto tectorigenin is tectorigenin-7-O-xylose glucoside.

Description

Background technique [0001] It is known that Tectorigenin or glycosides and derivatives of Tectorigenin (Tectorigenin) is one of the flavonoids present in Iridaceae or leguminous plants, and it will activate Sirtuin (see Patent Document 1), activate expression of the Bmal1 gene, etc. (see Patent Document 2). Since irisaxanthins are contained in plants, they are considered to be relatively safe and easy to ingest on a daily basis, but there are many things that are not clear about their activity or function. [0002] [Prior art literature] [0003] [Patent Document] [0004] [Patent Document 1] Japanese Patent Laid-Open No. 2006-298876 [0005] [Patent Document 2] Japanese Patent Laid-Open No. 2013-56866 Contents of the invention [0006] [Problem to be solved by the invention] [0007] Therefore, in the present invention, various studies have been conducted in order to find novel uses and functions of irisaxanthins. [0008] [Technical means to solve the problem] [0...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/352A61P3/04A61P1/16A61K8/49A61K8/60A61Q19/00
CPCA61Q19/00A23L33/10A23L33/105A61K8/498A61K8/602A61K31/352A61K31/7048A23V2002/00A61K2300/00A23V2200/332A23V2200/318A23V2200/30A23V2250/21
Inventor 中岛千绘城戸弥生神谷智康锷田仁人山口和也高垣欣也
Owner TOYO SHINYAKU KK
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