Application of glycyrrhizic acid and pharmaceutically acceptable salt thereof to preparation of antidepressant drugs

Abstract

The invention provides application of glycyrrhizic acid and a pharmaceutically acceptable salt thereof to preparation of antidepressant drugs, and specifically, application of the glycyrrhizic acid and the pharmaceutically acceptable salt thereof to preparation of the antidepressant drugs as a sole active component, application of the glycyrrhizic acid and the pharmaceutically acceptable salt thereof as an antidepressant drug synergist or application of the glycyrrhizic acid and the pharmaceutically acceptable salt thereof to treatment of treatment-refractory depression with combined application of the antidepressant drugs. According to the invention, clinical tests show that the glycyrrhizic acid and/or the pharmaceutically acceptable salt of the glycyrrhizic acid can achieve obvious synergistic effect on the antidepressant drugs and can rapidly, safely and effectively improve symptoms of depression in clinical application; therefore, the glycyrrhizic acid and/or the pharmaceuticallyacceptable salt of the glycyrrhizic acid can be used as the sole active component for preparing the antidepressant drugs, can be used for preparing the antidepressant drug synergist or can be appliedto treatment of treatment-refractory depression with combined application of the antidepressant drugs, can be applied to treatment of different depression, can improve the antidepressant effects of the drugs, is cheap, easily available, safe and non-toxic, and has good clinical application prospects.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular to the application of glycyrrhizic acid and its pharmaceutically acceptable salts in the preparation of antidepressants, especially to the use of glycyrrhizic acid and its pharmaceutically acceptable salts as the only active ingredient in the preparation of antidepressants , as an antidepressant drug synergist and its application in the treatment of refractory depression with combined use of antidepressants. Background technique [0002] Glycyrrhizic acid is the main active ingredient in licorice. Licorice is a traditional Chinese medicinal material with a long history of application. In the Eastern Han Dynasty, "Shen Nong's Materia Medica" called licorice "beautiful grass" and "dense sweet", and listed it as top grade. According to traditional Chinese medicine, licorice is sweet and flat, which is a good medicine for invigorating the spleen and Qi, relieving coughs and di...

AI Technical Summary

Problems solved by technology

[0003] However, there are no reports of glycyrrhizic acid as an antidepressant, antidepressant drug synergist, or combined use of antidepressant drugs in the treatment of refractory depression

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