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Double-core-cobalt bacteriostatic material and preparing method thereof

A technology of antibacterial materials, methoxymethyl isophthalic acid, applied in chemical instruments and methods, antibacterial drugs, chemicals for biological control, etc., can solve problems such as high cost and environmental pollution

Active Publication Date: 2019-04-16
河南十月企业管理咨询有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the reported bacteriostatic agents are complexes containing noble metals or heavy metal ions, and there are problems such as high cost or environmental pollution when used. However, the synthesis of cheap non-heavy metal complex bacteriostatic agents has a broader research space and value.

Method used

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  • Double-core-cobalt bacteriostatic material and preparing method thereof
  • Double-core-cobalt bacteriostatic material and preparing method thereof
  • Double-core-cobalt bacteriostatic material and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh 10.5mg (0.05mmoL) of 5-methoxymethylisophthalic acid, 9.2mg (0.05mmoL) of 1,2-bis(4-pyridyl)ethane and 14.1mg (0.05mmoL) of cobalt sulfate ( CoSO 4 ·7H 2 O) in a 25mL beaker; add 8mLH 2 O, stirred at room temperature for 15 minutes, then transferred to a 25mL polytetrafluoroethylene-lined reactor, heated to 130°C, and reacted at a constant temperature under this condition for 3 days; finally, the temperature was lowered to room temperature at a rate of 8°C / h, and filtered to obtain pink Color block crystals were obtained, and the single crystal of the coordination polymer was obtained with a yield of 64% (based on Co).

[0024] Take the coordination polymer of Example 1 and carry out structural characterization analysis

[0025] (1) Determination of the crystal structure of the coordination polymer

[0026] Single crystal diffraction data of coordination polymers were tested on Agilent Xcalibur&Gemini E CCO X-ray single crystal diffractometer with a single cry...

Embodiment 2

[0035] Weigh 10.5mg (0.05mmoL) of 5-methoxymethylisophthalic acid, 9.2mg (0.05mmoL) of 1,2-bis(4-pyridyl) and 12.4mg (0.05mmoL) of cobalt acetate (Co(Ac )2·4H 2 O) in a 25mL beaker; add 8mLH 2 O, stirred at room temperature for 10 minutes, then transferred to a 25mL polytetrafluoroethylene-lined reactor, heated to 130°C, and reacted at a constant temperature for 3 days under this condition; finally cooled to room temperature at a cooling rate of 8°C / h, filtered to obtain pink Color blocky crystals, the single crystal of the coordination polymer was obtained with a yield of 62% (based on Co).

[0036] In order to verify the beneficial effect of the present invention, the inhibitory ability of Example 1 and Example 2 to Gram-positive Staphylococcus aureus (Staphyococcus Aureus) and Gram-negative Escherichia coli (Escherichia Cocli) was measured respectively by using the single disc method. The result is as follows:

[0037] Table 3 is the antibacterial activity of 5-methoxyme...

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Abstract

The invention discloses a double-core-cobalt bacteriostatic material and a preparing method thereof. The double-core-cobalt bacteriostatic material is a 5-methoxymethyl isophthalic acid cobalt coordination polymer, and the chemical formula of the basic structural unit is [CoL(bpa)], wherein L represents the complete proton-stripping state of 5-methoxymethyl isophthalic acid, and bpa represents 1,2-bis(4-pyridyl)ethane. According to the double-core-cobalt bacteriostatic material and the preparing method thereof, a hydrothermal reaction method is utilized, 5-methoxymethyl isophthalic acid and 1,2-bis(4-pyridyl)ethane serve as ligands and cobalt nitrate or cobalt acetate serves as a metal source, and 5-methoxymethyl isophthalic acid, 1,2-bis(4-pyridyl)ethane and cobalt nitrate or cobalt acetate are heated in water for 3 days at 130 DEG C to obtain the coordination polymer. The 5-methoxymethyl isophthalic acid cobalt coordination polymer has a double-core-cobalt structure; under the concentration of 2.5 g / L, the coordination polymer has the bacteriostatic annulus diameter of 17.00 mm on staphylococcus aureus, and has the bacteriostatic annulus diameter of 19.2 mm on escherichia coli, and can serve as the bacteriostatic material.

Description

technical field [0001] The invention belongs to the field of inorganic chemistry and relates to antibacterial materials, in particular to a binuclear cobalt antibacterial material and a preparation method thereof. technical background [0002] Bacteriostatic material refers to a new type of functional material that can kill or inhibit the growth and reproduction of microbial cells. According to its chemical structure, it can be divided into: inorganic antibacterial materials, organic antibacterial materials and composite antibacterial materials. At present, the disadvantages of inorganic antibacterial agents such as poor solubility and easy degradation of organic antibacterial agents limit their application range. Inorganic and organic compounds with antibacterial properties are assembled by physical or chemical methods to form a combination of inorganic and organic antibacterial properties. The composite material of bacterial material has become a hot research direction. ...

Claims

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Application Information

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IPC IPC(8): C07F15/00A01P1/00A61P31/04
CPCA61P31/04C07F15/065Y02A50/30
Inventor 王世民刘帅帅郭丹买文鹏于琼燕王非张红松段群鹏卢奎
Owner 河南十月企业管理咨询有限公司
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