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Preparation method of Qingjin oral liquid

A technology of Qingjin oral liquid and filtrate, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, drug delivery, etc., can solve the problems of high energy consumption, low extraction efficiency, and large amount of solvent in the follow-up process, and reach the goal of solvent consumption Large size, high extraction efficiency, and less solvent consumption

Inactive Publication Date: 2019-05-07
JIANGSU EHAI PHARMA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The conventional water decoction extraction process has the disadvantages of low extraction efficiency, long extraction time, large amount of solvent, and high energy consumption in subsequent sections.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] 250g of Radix Isatidis, 125g of Osmanthus japonicus, 50g of wild chrysanthemum, 250g of Houttuynia cordata, 75g of Tinglizi, 75g of perilla seed, 250g of geranium, 125g of short tea, 75g of Baibu, 75g of coltsfoot flower, 125g of astragalus, Add 12.5g of ganoderma lucidum to dynamic countercurrent extraction, filter the extract, concentrate the filtrate to an appropriate amount, add equal times of ethanol, let it stand for precipitation, filter, recover ethanol from the filtrate, and concentrate to an appropriate amount; (2) Take 325g of sucrose, add water and boil to dissolve, Filtrate, mix the filtrate with the above-mentioned concentrated solution, add Vitex oil and an appropriate amount of preservatives, make 1000ml, stir well, pack separately, and obtain. Dynamic countercurrent extraction process parameters: the medicinal materials are crushed into fine powder, the ratio of solid to liquid is 1:4, the extraction time is 30 minutes, the extraction temperature is 60°C...

Embodiment 2

[0014] 250g of Radix Isatidis, 125g of Osmanthus japonicus, 50g of wild chrysanthemum, 250g of Houttuynia cordata, 75g of Tinglizi, 75g of perilla seed, 250g of geranium, 125g of short tea, 75g of Baibu, 75g of coltsfoot flower, 125g of astragalus, Add 12.5g of ganoderma lucidum to dynamic countercurrent extraction, filter the extract, concentrate the filtrate to an appropriate amount, add equal times of ethanol, let it stand for precipitation, filter, recover ethanol from the filtrate, and concentrate to an appropriate amount; (2) Take 325g of sucrose, add water and boil to dissolve, Filtrate, mix the filtrate with the above-mentioned concentrated solution, add Vitex oil and an appropriate amount of preservatives, make 1000ml, stir well, pack separately, and obtain. Dynamic countercurrent extraction process parameters: the medicinal materials are crushed into fine powder, the ratio of solid to liquid is 1:4, the extraction time is 60 minutes, the extraction temperature is 50°C...

Embodiment 3

[0016] 250g of Radix Isatidis, 125g of Osmanthus japonicus, 50g of wild chrysanthemum, 250g of Houttuynia cordata, 75g of Tinglizi, 75g of perilla seed, 250g of geranium, 125g of short tea, 75g of Baibu, 75g of coltsfoot flower, 125g of astragalus, Add 12.5g of ganoderma lucidum to dynamic countercurrent extraction, filter the extract, concentrate the filtrate to an appropriate amount, add equal times of ethanol, let it stand for precipitation, filter, recover ethanol from the filtrate, and concentrate to an appropriate amount; (2) Take 325g of sucrose, add water and boil to dissolve, Filtrate, mix the filtrate with the above-mentioned concentrated solution, add Vitex oil and an appropriate amount of preservatives, make 1000ml, stir well, pack separately, and obtain. Dynamic countercurrent extraction process parameters: the medicinal materials are crushed into fine powder, the ratio of solid to liquid is 1:4, the extraction time is 20 minutes, the extraction temperature is 70°C...

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PUM

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a preparation method of Qingjin oral liquid. According to the method, dynamic countercurrent extractionis adopted, wherein parameters of dynamic countercurrent extraction are selected; twelve medicinal materials in the Qingjin syrup are extracted; a single factor and an orthogonal experiment are combined and the bergenin transfer rate is used as an index, multi-index weighting is carried out to determine key factors. The optimal process parameters of the factors such as the medicinal material granularity, the extraction frequency, the material-liquid ratio, the extraction time, the extraction temperature and the like are determined. According to the present invention, the dynamic countercurrent extraction technology is adopted, such that the extraction temperature is low, the solvent consumption is low, the extraction efficiency is high, the energy consumption of the subsequent working section is low, the product quality is improved, and the product technical level can be significantly improved.

Description

field of invention [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a preparation method of Qingjin oral liquid. Background technique [0002] The deterioration of the environment will cause frequent occurrence of human diseases, and many diseases closely related to the seasons will attack the human body. In recent years, hazy weather in many parts of the country has led to concentrated outbreaks of respiratory diseases. Bronchitis is one of the most serious upper respiratory tract infections. According to the "National Health Survey Report" issued by the Ministry of Health in the past ten years, the number of respiratory diseases is more than 100 million people every year, and there is an increasing trend year by year. In 2016, the number of patients with respiratory diseases was nearly 200 million, and patients with bronchitis accounted for about 90 million. [0003] The Qingjin syrup developed and produced by our ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61K9/08A61P11/14A61P11/10A61P11/06A61P11/00
Inventor 郭麦平张艳侠
Owner JIANGSU EHAI PHARMA CORP
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