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Application of itraconazole in preparation of fungicides for prevention and control of plant pathogenic bacteria

A technology of plant pathogenic bacteria and itraconazole, which is applied in the application field of fungicides, can solve problems such as hazards, drug residues, killing non-target organisms, etc., and achieve broad market application prospects, good inhibitory activity, and good inhibitory activity.

Inactive Publication Date: 2019-05-14
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The long-term use of large quantities of chemical pesticides not only leads to resistance problems, but also causes pesticide residues, kills non-target organisms, pollutes the ecological environment, and eventually causes harm to the human body through bioaccumulation

Method used

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  • Application of itraconazole in preparation of fungicides for prevention and control of plant pathogenic bacteria
  • Application of itraconazole in preparation of fungicides for prevention and control of plant pathogenic bacteria
  • Application of itraconazole in preparation of fungicides for prevention and control of plant pathogenic bacteria

Examples

Experimental program
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Embodiment 1

[0029] In the InterBioScreen database (https: / / www.ibscreen.com / ), the present invention screened and synthesized the small molecule compound Itrakine based on the three-dimensional structure design of Fusarium graminearum CYP51B protein (sterol demethylation inhibitor target protein) azole.

[0030] Chemical name: 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)- 1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H -1,2,4-triazol-3-one;

[0031] English: 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1 , 3-dioxolan-4-y1]methoxy]phenyl]piperazin-1-y1]phenyl]-1,2,4-triazol-3-one,

[0032] Molecular formula: C 35 h 38 CL 2 N 8 o 4 , molecular weight: 705.63, the structural formula is as follows:

[0033]

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Abstract

The invention discloses an application of itraconazole in the preparation of fungicides for the prevention and control of plant pathogenic bacteria. Experiments prove herein that the itraconazole hasgood inhibitory activity against the main diseases of important grain crops, including fusarium graminearum causing wheat scab, magnaporthe oryzae causing rice blast, rhizoctonia cerealis causing sheath blight and curvularia maize causing maize leaf spot; moreover, the itraconazole has good inhibitory activity against the physalospora piricola causing apple ring rot, valsa mali causing apple rot and alternaria tenuifolia causing leaf spot disease of fruits and vegetables; the itraconazole also has good inhibitory activity against soil-borne diseases that are extremely difficult to prevent andcontrol in agricultural production, such as fusarium oxysporum causing blight, and the inhibitory activity is even better than those of traditional fungicides such as carbendazim and tebuconazole. Forthe first time, the itraconazole, a green small-molecular compound screened through three-dimensional structures of target proteins, is applied to the prevention and control of important plant diseases in agricultural production and has a good market application prospect.

Description

technical field [0001] The invention belongs to the technical field of plant protection, and specifically relates to the application of itraconazole in the preparation of fungicides for preventing and treating plant pathogenic bacteria. Background technique [0002] The Food and Agriculture Organization of the United Nations (FAO) estimates that the loss of crop production in the world is about 40% (440-550 billion yuan) due to damage from diseases, insect pests and weeds, and the impact on trees is even more difficult to estimate. The losses recovered through the work of scientists and various technology extension personnel engaged in pest research all over the world reached 300-400 billion yuan. For a long time, chemical control has been the main means of controlling plant diseases. The long-term use of large quantities of chemical pesticides not only leads to resistance problems, but also causes pesticide residues, kills non-target organisms, pollutes the ecological envi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/653A01P3/00
Inventor 黄金光孙慧琳赵彦翔孙晓梅张淑颖
Owner QINGDAO AGRI UNIV
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