Natural drug external medicament for plasma resonance enhancement and preparation method and application thereof

A technology of plasmon resonance and natural medicine, which is applied in the direction of medical preparations containing active ingredients, drug combinations, and pharmaceutical formulas, can solve the problems of finished medicine and medication inconvenience, easy deterioration, etc., to promote skin capillary dilation, promote development, The effect of improving the treatment efficiency

Inactive Publication Date: 2019-05-17
GUANGDONG PROV MEDICAL INSTR INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most natural medicine extracts or extracts are rich in polysaccharides, proteins, lipids and other substances, which are easy to deteriorate under normal temperature and pressure, which brings inconvenience to both the finished medicine and the medicine.

Method used

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  • Natural drug external medicament for plasma resonance enhancement and preparation method and application thereof
  • Natural drug external medicament for plasma resonance enhancement and preparation method and application thereof
  • Natural drug external medicament for plasma resonance enhancement and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 (the anti-melanin natural medicine external medicament system that plasmon resonance enhances)

[0040] The system preparation of embodiment 1:

[0041] 1) Mix the insect repellent Vernonia seeds with deionized water at a mass ratio of 1:10, heat in a water bath until boiling, then cool and filter, and separate the filtrate by high-speed centrifugation at 10,000r / min for 8 minutes, and collect the centrifugate to obtain the repellent Vernonia water extract.

[0042] 2) Mix the 1mmol / L silver nitrate solution and Vernonia vernonia water extract at a volume ratio of 5:1, keep it at room temperature in the dark for 2 days, and obtain a plasmon resonance-enhanced natural medicinal external application system.

[0043] attached Figure 2~4 The ultraviolet absorption spectra of the plasmon resonance-enhanced Vernonia insecticide system, the extract of Vernonia insect repellent and the silver nanoparticle redispersed hydrosol in this embodiment are shown respect...

Embodiment 2

[0049] Embodiment 2 (plasmon resonance enhanced vitiligo natural medicine external medicament system)

[0050] The system preparation of embodiment 2:

[0051] 1) Mix chicken bone grass, psoralen, and deionized water in a mass ratio of 1:1:10, heat in a water bath until boiling, then cool and filter, and separate the filtrate by high-speed centrifugation at 10,000r / min for 8 minutes, and collect the centrifugate , to obtain the natural medicinal water extract.

[0052] 2) After mixing 1mmol / L silver nitrate solution and natural medicine water extract at a volume ratio of 5:1, keep it at room temperature in the dark for 2 days, and obtain a natural medicine external use system for treating vitiligo with plasma resonance enhancement.

[0053] Drug system stability test:

[0054] Place the pharmaceutical system for external use in this embodiment away from light under normal conditions. Compared with the fresh drug system, the drug system that has been placed for 6 months has ...

Embodiment 3

[0055] Example 3 (Plasma resonance enhanced arthritis external drug system)

[0056] The system preparation of embodiment 3:

[0057] 1) Mix the dried mouse melon and deionized water at a mass ratio of 1:10, heat in a water bath until boiling, then cool and filter, and separate the filtrate by high-speed centrifugation at 10,000r / min for 8 minutes, and collect the centrifugate to obtain natural medicinal water Extraction.

[0058] 2) After mixing 1mmol / L silver nitrate solution and natural medicine water extract at a volume ratio of 5:1, keep it at room temperature in the dark for 2 days, and obtain a natural medicine external application system for treating arthritis with plasma resonance enhancement .

[0059] Drug system stability test:

[0060] Place the pharmaceutical system for external use in this embodiment away from light under normal conditions. Compared with the fresh drug system, the drug system that has been placed for 6 months has no mold formation, no obviou...

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PUM

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Abstract

The invention discloses a natural drug external medicament for plasma resonance enhancement and a preparation method and application thereof. The preparation method includes mixing a natural drug extract and a metal salt solution for reaction to obtain the natural drug external medicament for plasma resonance enhancement containing nanoparticles. The application of the natural drug external medicament for the plasma resonance enhancement is also disclosed. The natural drug extract is utilized to prepare an external nano-medicament system for the plasma resonance enhancement in situ. The external medicament system can be directly applied to the field of drug and health. By means of addition of the nanoparticles for the plasma resonance enhancement, the near-field optical effect and photo-thermal properties can be achieved to help to achieve phototherapy for diseases under mild natural light conditions and promote the development of natural drugs, especially modern drugs for traditionalChinese drug preparations.

Description

technical field [0001] The invention relates to a plasmon resonance-enhanced natural medicine for external use, a preparation method and application thereof. Background technique [0002] Medicines for external use can be directly applied to the skin surface, but it is difficult to break through the barrier of the stratum corneum, and the drug utilization rate is low. In order to improve the drug utilization, various penetration enhancers have received extensive attention, but most penetration enhancers have irritation or Toxic effects. Clinical phototherapy requires the support of light emitters or the administration of photosensitizing drugs, which greatly increases the risk of phototoxic reactions and normal skin damage in patients, and brings a lot of inconvenience to patients' treatment. Therefore, how to safely, effectively and conveniently improve external drug therapy has attracted the attention of more and more researchers. [0003] Natural medicines include anima...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61K36/48A61K36/487A61K36/185A61K36/746A61K35/64A61K36/896A61K36/886A61K36/258A61K36/284A61K36/232A61K36/736A61K36/286A61K35/618A61K36/888A61K36/236A61K36/076A61K36/537A61K36/287A61K36/738A61K36/481A61K36/238A61K36/752A61K36/71A61K36/65A61K36/533A61K35/644A61K47/02A61P17/00A61P19/02A61P29/00
Inventor 李娟杨明亮鲁道欢
Owner GUANGDONG PROV MEDICAL INSTR INST
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