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A method for removing off-flavors from thiazole

ActiveCN118084817BNo odorMeet industry standardsOrganic chemistryThiazoleAlcohol
The application discloses a method for removing off-flavor of thiozole. The method comprises the following steps: (1) mixing crude thiozole to be treated with an oily solvent and standing; if the mixture is stratified, transferring the oily solvent layer to a new container; if the mixture is not stratified, directly performing subsequent operations; (2) performing vacuum distillation on the product of step (1) to remove the solvent and obtaining a paste; (3) adding a lower alcohol to the paste and heating to dissolve; (4) performing vacuum distillation on the solution of step (3) to remove the solvent; and (5) performing vacuum distillation on the product of step (4) again to distill thiozole products. The method removes off-flavor by-products in the crude thiozole through extraction with an oily solvent, removes part of impurities through dissolution and distillation with a lower alcohol, distills thiozole at last, separates high-boiling-point residue impurities, removes off-flavor, retains the characteristic odor of thiozole, makes the prepared thiozole smell like beef and have nutty aroma, and has no off-flavor, and thus meets the industry standard.
Owner:江西科兴药业有限公司