Pharmaceutical composition and use thereof in promoting skin wound healing

A technology of composition and mixture, which is applied in the application field of pharmaceutical composition to promote skin wound healing, can solve the problems of losing skin luster and flexibility, affecting the overall appearance of skin, and not being able to meet the treatment of wounds, and achieve low immunogenicity sex, reduce wound healing time, and reduce scar formation

Active Publication Date: 2019-06-14
北京隆祺生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the trauma is serious, such as scalds and burns, the depth and area of ​​the skin wound is large, and it is difficult to heal quickly by itself, which makes the patient suffer from more continuous pain, and the treatment cycle becomes longer and the wound is prone to repeated infection. After the wound has healed, it will also produce a large scar, lose the luster and flexibility of the skin, affect the overall appearance of the skin, and cause a great psychological shadow to people
Although there are many types of traditionally used medicines such as topical medicines and ointments, there are currently no medicines on the market that are specifically used to promote rapid wound healing and reduce scars, so they cannot meet the needs of wound treatment

Method used

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  • Pharmaceutical composition and use thereof in promoting skin wound healing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1. Preparation of human umbilical cord mesenchymal stem cells

[0021] Under sterile conditions, take the umbilical cord and cut it into small pieces of about 3 cm, draw out the blood vessel, take the perivascular material and cut it into pieces, first digest it with 1‰ type IV collagenase for 2 hours, and then centrifuge it at 2000r / min for 10 minutes, take The lower layer was digested with 0.25% trypsin-PBS at 37°C for 25 minutes, then centrifuged at 2000r / min for 10min, and the cell pellet was digested with 0.25% trypsin solution, then centrifuged at 800r / min for 10min , take the cell pellet to 1×10 6 The cells / ml density is suspended in the culture medium, and the culture medium is a commercially available serum-free medium for mesenchymal stem cells. Set at 37°C, 100% humidity, 5% CO 2 Cultivate in a dark environment, change the medium every 3 days, after 2 days, fibroblasts can be seen growing at the bottom of the bottle, and after about 10 days, they can reach ...

Embodiment 2

[0037] A pharmaceutical composition was prepared in the same manner as in Example 1. The difference is that, based on the total weight of the Chinese medicine mixture, the Chinese medicine mixture includes 13 parts of Kochia scoparia powder, 12 parts of Polygonum multiflorum root powder, 8 parts of beeswax powder, 4 parts of plantain powder, and 9 parts of dandelion powder. In addition, the ointment is glycerin, the preservative is a mixture of butyl hydroxybenzoate and nisin, and the weight ratio of butyl hydroxybenzoate and nisin is 2:3, and the moisturizing agent is sorbitol and hyaluronic acid A mixture of sodium, and the weight ratio of sorbitol and sodium hyaluronate is 1:2.

[0038] In addition, the stirring time was 4 hours, the stirring direction was changed every 6 minutes, and a paste-like object was obtained after the stirring was completed.

Embodiment 3

[0040] A pharmaceutical composition was prepared in the same manner as in Example 1. The difference is that the pharmaceutical composition includes, based on the total weight of the pharmaceutical composition: 5 parts of human umbilical cord mesenchymal stem cells, 1 part of human serum albumin, 0.1 part of low-molecular-weight heparin calcium, and 0.3 parts of vitamin C , 15 parts of traditional Chinese medicine, 20 parts of ointment, 0.2 part of preservative, 1 part of moisturizing agent, 86.8 parts of water, wherein, the Chinese medicine mixture is based on its total weight, including 37 parts of aloe powder, 12 parts of peppermint powder, 11 parts of Kochia Seed powder, 15 parts Polygonum multiflorum powder, 8 parts beeswax powder, 5 parts plantain powder, 12 parts dandelion powder. Additionally, the ointment is glycerin, the preservative is sorbic acid, and the humectant is butylene glycol.

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Abstract

The invention relates to a pharmaceutical composition and use thereof in promoting skin wound healing. The pharmaceutical composition includes mesenchymal stem cells and a traditional Chinese medicinemixture. The traditional Chinese medicine mixture comprises aloe and mint. The pharmaceutical composition utilizes the strong proliferation and differentiation capability of the mesenchymal stem cells and is applied to skin wound healing in conjunction with the traditional Chinese medicines such as the aloe and the mint, the wound healing period can be obviously and effectively shortened, the formation of scars is reduced, and the treatment needs are met.

Description

technical field [0001] The invention relates to the technical field of wound treatment, in particular to a pharmaceutical composition and its application in promoting skin wound healing. Background technique [0002] In daily life, people's skin will inevitably be scratched, burned or scalded. Skin healing is a complex process that involves many factors. It needs to go through the stages of inflammatory response, granulation tissue hyperplasia and epithelial tissue formation. The healing cycle is generally about 21 days. For milder wounds, patients often use anti-inflammatory and anti-inflammatory drugs, pain relievers and other drugs to treat them, and then the wound will heal naturally. However, when the trauma is serious, such as scalds and burns, the depth and area of ​​the skin wound is large, and it is difficult to heal quickly by itself, which makes the patient suffer from more continuous pain, and the treatment cycle becomes longer and the wound is prone to repeated...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/28A61K36/896A61K36/886A61K38/38A61P17/02A61K31/375A61K31/727A61K35/644
Inventor 吴国栋李大军
Owner 北京隆祺生物科技有限公司
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