Supercharge Your Innovation With Domain-Expert AI Agents!

A kind of mutant type of human tumor suppressor gene pml and its application

A tumor suppressor gene, mutant technology, applied in the field of genetic engineering, can solve the problem that the effect of tumor suppressor gene has not yet been seen

Active Publication Date: 2021-01-12
NORTHWEST A & F UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the research on the effect of specific tumor suppressor genes in cervidae species by combining comparative genomics and experimental biology methods

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of mutant type of human tumor suppressor gene pml and its application
  • A kind of mutant type of human tumor suppressor gene pml and its application
  • A kind of mutant type of human tumor suppressor gene pml and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027]The present invention will be further described in detail below with reference to the accompanying drawings and embodiments. The embodiments are only used to explain the present invention and not to limit the protection scope of the present invention.

[0028](1) Identification of deer family positive selection genes

[0029]First, the genomes of deer family species including roe deer, white-lipped deer, reindeer, elk, white-tailed deer, small muntjac, red muntjac and black muntjac were assembled manually. The genomes of 8 deer species (roe deer, white-lipped deer, reindeer, elk, white-tailed deer, small muntjac, red muntjac and black muntjac) and 53 outgroup species were selected. The above-mentioned genomes were respectively compared to the goat reference genome (Capra hircus, ARS1) by LAST whole-genome comparison software to obtain pairwise genome comparison files. Then, through the multiz multiple sequence comparison software, the above pairwise comparison results are combined i...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a human cancer suppressor gene PML mutant and application thereof. A cervidae mutant human cancer suppressor gene PM is identified by comparative genomics, and the human cancersuppressor gene PML mutant type is shown in SEQ. ID. NO. 2. The amino acid sequence of the encoded human PML cervidae mutant protein is shown in SEQ. ID. NO. 1. By means of test and analysis of a cancer cell growth inhibition effect of the cervidae mutant PML gene, the cervidae mutant PML can inhibit the growth of a variety of cancer cells, and has a stronger anti-cancer effect than a human PML gene. The cervidae mutant human cancer suppressor gene PML can be applied to prevention and treatment of the cancer.

Description

Technical field[0001]The invention belongs to the field of genetic engineering, and relates to the application of the human tumor suppressor gene PML Cervidae mutant and its encoded mutant protein in cancer treatment drugs, kits and the like that inhibit the growth of cancer cells.Background technique[0002]Cancer treatment is difficult and mortality is the most serious public health problem. In recent years, the incidence of cancer has increased significantly in some areas, and the mortality rate has also been gradually increasing. However, there is currently a lack of broad-spectrum, cheap, and effective cancer prevention and treatment drugs. The existing cancer treatment methods, such as radiotherapy and chemotherapy, cause great damage to the human body, and the treatment effect is not good. There are species with stronger anti-cancer ability in nature, and their specific gene mutations make them have stronger cancer resistance. Through the identification of effective mutant gene...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C12N15/12C07K14/47A61K38/17A61P35/00
Inventor 王禹邱强姜雨王文李志鹏刘蓉
Owner NORTHWEST A & F UNIV
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com