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A kind of mutant type of human tumor suppressor gene pml and its application

A tumor suppressor gene, mutant technology, applied in the field of genetic engineering, can solve the problem that the effect of tumor suppressor gene has not yet been seen

Active Publication Date: 2021-01-12
NORTHWEST A & F UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

There is no report on the research on the effect of specific tumor suppressor genes in cervidae species by combining comparative genomics and experimental biology methods

Method used

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  • A kind of mutant type of human tumor suppressor gene pml and its application
  • A kind of mutant type of human tumor suppressor gene pml and its application
  • A kind of mutant type of human tumor suppressor gene pml and its application

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Embodiment Construction

[0027]The present invention will be further described in detail below with reference to the accompanying drawings and embodiments. The embodiments are only used to explain the present invention and not to limit the protection scope of the present invention.

[0028](1) Identification of deer family positive selection genes

[0029]First, the genomes of deer family species including roe deer, white-lipped deer, reindeer, elk, white-tailed deer, small muntjac, red muntjac and black muntjac were assembled manually. The genomes of 8 deer species (roe deer, white-lipped deer, reindeer, elk, white-tailed deer, small muntjac, red muntjac and black muntjac) and 53 outgroup species were selected. The above-mentioned genomes were respectively compared to the goat reference genome (Capra hircus, ARS1) by LAST whole-genome comparison software to obtain pairwise genome comparison files. Then, through the multiz multiple sequence comparison software, the above pairwise comparison results are combined i...

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Abstract

The invention discloses a human cancer suppressor gene PML mutant and application thereof. A cervidae mutant human cancer suppressor gene PM is identified by comparative genomics, and the human cancersuppressor gene PML mutant type is shown in SEQ. ID. NO. 2. The amino acid sequence of the encoded human PML cervidae mutant protein is shown in SEQ. ID. NO. 1. By means of test and analysis of a cancer cell growth inhibition effect of the cervidae mutant PML gene, the cervidae mutant PML can inhibit the growth of a variety of cancer cells, and has a stronger anti-cancer effect than a human PML gene. The cervidae mutant human cancer suppressor gene PML can be applied to prevention and treatment of the cancer.

Description

Technical field[0001]The invention belongs to the field of genetic engineering, and relates to the application of the human tumor suppressor gene PML Cervidae mutant and its encoded mutant protein in cancer treatment drugs, kits and the like that inhibit the growth of cancer cells.Background technique[0002]Cancer treatment is difficult and mortality is the most serious public health problem. In recent years, the incidence of cancer has increased significantly in some areas, and the mortality rate has also been gradually increasing. However, there is currently a lack of broad-spectrum, cheap, and effective cancer prevention and treatment drugs. The existing cancer treatment methods, such as radiotherapy and chemotherapy, cause great damage to the human body, and the treatment effect is not good. There are species with stronger anti-cancer ability in nature, and their specific gene mutations make them have stronger cancer resistance. Through the identification of effective mutant gene...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N15/12C07K14/47A61K38/17A61P35/00
Inventor 王禹邱强姜雨王文李志鹏刘蓉
Owner NORTHWEST A & F UNIV
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