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Human cancer suppressor gene PML mutant and application thereof

A tumor suppressor gene, mutant technology, applied in the field of genetic engineering, can solve the problem that the effect of tumor suppressor gene has not yet been seen

Active Publication Date: 2019-06-25
NORTHWEST A & F UNIV
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Problems solved by technology

There is no report on the research on the effect of specific tumor suppressor genes in cervidae species by combining comparative genomics and experimental biology methods

Method used

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  • Human cancer suppressor gene PML mutant and application thereof
  • Human cancer suppressor gene PML mutant and application thereof
  • Human cancer suppressor gene PML mutant and application thereof

Examples

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Embodiment Construction

[0027] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments, which are only used to explain the present invention rather than limit the protection scope of the present invention.

[0028] (1) Identification of positively selected genes in cervidae

[0029] First, the genomes of cervidae species, including roe deer, white-lipped deer, reindeer, elk, white-tailed deer, small deer, barking deer and black deer, were artificially assembled. The genomes of 8 species of cervidae (roe deer, white-lipped deer, reindeer, elk, white-tailed deer, muntjac, barking deer, and black muntjac) and 53 outgroup species were selected. The above-mentioned genomes were respectively compared to the goat reference genome (Capra hircus, ARS1) by the LAST whole genome comparison software, and a pairwise genome comparison file was obtained. Then, through the multiz multiple sequence alignment software, the above pairwise alignment ...

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Abstract

The invention discloses a human cancer suppressor gene PML mutant and application thereof. A cervidae mutant human cancer suppressor gene PM is identified by comparative genomics, and the human cancersuppressor gene PML mutant type is shown in SEQ. ID. NO. 2. The amino acid sequence of the encoded human PML cervidae mutant protein is shown in SEQ. ID. NO. 1. By means of test and analysis of a cancer cell growth inhibition effect of the cervidae mutant PML gene, the cervidae mutant PML can inhibit the growth of a variety of cancer cells, and has a stronger anti-cancer effect than a human PML gene. The cervidae mutant human cancer suppressor gene PML can be applied to prevention and treatment of the cancer.

Description

technical field [0001] The invention belongs to the field of genetic engineering, and relates to the application of human tumor suppressor gene PML cervidae mutant type and its coded mutant protein in cancer treatment medicine, kit and the like for inhibiting the growth of cancer cells. Background technique [0002] Cancer treatment is difficult and mortality rate is high, which is the most serious public health problem. In recent years, the incidence of cancer has increased significantly in some areas, and the mortality rate has also shown a gradual upward trend. However, there is currently a lack of broad-spectrum, cheap, and effective cancer prevention and treatment drugs. Existing cancer treatment methods, such as radiotherapy and chemotherapy, cause great damage to the human body, and the treatment effect is not good. In nature, there are species with stronger anti-cancer ability, and their specific gene mutations make them have stronger cancer resistance. By identif...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/12C07K14/47A61K38/17A61P35/00
Inventor 王禹邱强姜雨王文李志鹏刘蓉
Owner NORTHWEST A & F UNIV
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