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Antibacterial composition and wound dressing containing same

An antibacterial composition and extract technology, applied in the field of natural medicinal chemistry, can solve problems such as decay, wound non-healing, pain, etc., and achieve the effect of preventing infection and preventing bacterial infection of wounds

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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, if the wound after surgery is not treated properly, it will often cause infection, resulting in wound non-healing, pain, decay, etc.

Method used

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  • Antibacterial composition and wound dressing containing same
  • Antibacterial composition and wound dressing containing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Preparation of antibacterial composition

[0025] This embodiment provides an antibacterial composition. The antibacterial composition comprises an extract of Magnolia striata and an extract of Bletilla striata; the weight ratio of the extract of Magnolia striata and the extract of Bletilla striata is 5:2.

[0026] The extract of Mignonaceae is prepared by the following method:

[0027] (1) Using 95% ethanol with a volume fraction of ethanol for heating and refluxing extraction twice, the extracts of the two times were combined and concentrated and dried to obtain the ethanolic extract of the Chinese herbal medicine. The dosage ratio of ginger to ethanol is 1g:8mL;

[0028] (2) Put the dried Alcohol extract on silica gel column, first eluting with 3 times column volume of organic solvent A to remove impurities; then use 5 times column volume of organic solvent B for elution, collecting organic The fractions eluted by solvent B are concentrated and dried to obtain the...

Embodiment 2

[0032] Example 2 Preparation of antibacterial composition

[0033] This embodiment provides an antibacterial composition. The antibacterial composition comprises an extract of Magnolia striata and an extract of Bletilla striata; the weight ratio of the extract of Magnolia striata and the extract of Bletilla striata is 3:2.

[0034] The extract of Mignonaceae is prepared by the following method:

[0035] (1) The traditional Chinese medicine Mujiang Zi was heated and refluxed with ethanol with a volume fraction of 70% for 2 times, 40 minutes each time, the extracts of the 2 times were combined, and concentrated and dried to obtain the ethanol extract of Mujiang Zi; The dosage ratio of ginger to ethanol is 1g:10mL;

[0036] (2) Put the dried Alcohol extract on a silica gel column, first eluting with 2 column volumes of organic solvent A to remove impurities; then eluting with 6 column volumes of organic solvent B, and collect organic The fractions eluted by solvent B are concentrated an...

Embodiment 3

[0040] Example 3 Preparation of antibacterial composition

[0041] This embodiment provides an antibacterial composition. The antibacterial composition comprises an extract of Magnolia striata and an extract of Bletilla striata; the weight ratio of the extract of Magnolia striata and the extract of Bletilla striata is 4:2.

[0042] The extract of Mignonaceae is prepared by the following method:

[0043] (1) The traditional Chinese medicine Mujiang Zi is heated and refluxed with ethanol with a volume fraction of 80% for 2 times, each time for 80 minutes, the extracts of the 2 times are combined, and after concentration and drying, an ethanol extract of Mujiang Zi is obtained; The dosage ratio of ginger to ethanol is 1g:10mL;

[0044] (2) Put the dried Alcohol extract on silica gel column, first eluting with 3 times column volume of organic solvent A to remove impurities; then use 5 times column volume of organic solvent B for elution, collecting organic The fractions eluted by solvent...

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Abstract

The invention specifically discloses an antibacterial composition and a wound dressing containing the same. The antibacterial composition comprises a litsea pungens extract and a bletilla striata extract; and the weight ratio of the litsea pungens extract to the bletilla striata extract is 3-5: 2. The litsea pungens extract is prepared by a method comprising the following steps: extracting a traditional Chinese medicine litsea pungens with ethanol to obtain a litsea pungens ethanol extract; and performing silica gel column chromatography on the litsea pungens ethanol extract to obtain the litsea pungens extract. The bletilla striata extract is prepared by a method comprising the following steps: extracting a traditional Chinese medicine bletilla striata with ethanol to obtain bletilla striata ethanol extract; and performing ODS column chromatography on the bletilla striata ethanol extract to obtain the bletilla striata extract. The antibacterial composition has a good antibacterial effect, and especially has an excellent MRSA resistance effect. When the antibacterial composition is applied to the wound dressing, wound bacterial infection can be effectively prevented, and particularly MRSA infection can be prevented.

Description

Technical field [0001] The invention relates to the technical field of natural medicine chemistry, in particular to an antibacterial composition and a wound dressing containing the composition. Background technique [0002] Wound dressings are materials used to wrap wounds to cover sores, wounds or other damage. Traditional dressings are mainly dry gauze and oil gauze. Dry gauze can be used to supervise and cover wounds, but it cannot be used for infectious wounds and does not promote wound healing. At the same time, its ability to manage exudate is limited, and it will cause adhesion wounds during use, which will cause new epithelial tissue re-damage and bleeding, and aggravate the pain of changing dressings. Oil gauze means that it contains petroleum jelly or triglycerides, which can play a role in not adhering to the wound; but it also does not promote the entire healing process of the wound; it is also ineffective on infected wounds. [0003] Wound infection is a pathologica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P31/04A61P17/02A61L15/40A61L15/46A61K36/54
CPCA61K36/54A61K36/898A61K2236/333A61K2236/55A61L15/40A61L15/46A61P17/02A61P31/04A61K2300/00
Inventor 吕秋兰
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