Formic acid injection and application thereof in treating cardiovascular and cerebrovascular diseases

A technology for cardiovascular and cerebrovascular diseases and injection, which is applied in cardiovascular system diseases, blood diseases, extracellular fluid diseases, etc., to achieve the effects of no hemolytic reaction, low cost, and strong pharmacological effects

Inactive Publication Date: 2019-07-09
甘肃玉璞肿瘤心血管病研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its application in the field of medicine is mainly used as a solvent, and its separate pharmaceutical preparations for the treatment of diseases have not been reported.

Method used

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  • Formic acid injection and application thereof in treating cardiovascular and cerebrovascular diseases
  • Formic acid injection and application thereof in treating cardiovascular and cerebrovascular diseases
  • Formic acid injection and application thereof in treating cardiovascular and cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Get 10L of ammonium nitrate injection with a concentration of 0.1%, add 800mg of formic acid, stir and mix evenly, and obtain formic acid with a formic acid concentration of 80ppm in 0.1% ammonium nitrate injection after the conventional filtration, filling, sealing, and disinfection processes Injection. Intravenous infusion of the formic acid injection can be used to treat hypertension and hyperlipidemia.

Embodiment 2

[0077] Take 10L of ammonium nitrate injection with a concentration of 0.2g / L, add 800mg of formic acid, stir and mix evenly, and obtain 0.2% ammonium nitrate injection with a concentration of formic acid of 80ppm after conventional filtration, filling, sealing and disinfection processes formic acid injection. Intravenous infusion of the formic acid injection can be used to treat hypertension and hyperlipidemia.

Embodiment 3

[0079] Get 10L concentration and be the ammonium nitrate injection of 0.3%, add the formic acid of 1.2g, after stirring and mixing evenly, obtain 0.3% formic acid concentration in the ammonium nitrate injection after routine filtration, filling, sealing, disinfection process is 120ppm Formic acid injection. The intravenous infusion of the formic acid injection can be used to treat arteriosclerosis.

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Abstract

The invention provides a formic acid injection and application thereof in treating cardiovascular and cerebrovascular diseases. 0.1-0.6 percent of an ammonium nitrate injection is used as a carrier and 80-200 ppm of formic acid is added into the carrier to prepare the formic acid injection. The formic acid injection can be administered by intravenous drip, and can be used for treating the cardiovascular and cerebrovascular diseases such as hypertension, hyperlipidemia, arteriosclerosis and the like. Pharmacological tests show that the formic acid injection has the disease treatment mechanism that a hard fatty acid with more than 17 carbon atoms is dissolved into two or more than two soft fatty acids, so that a series of the cardiovascular and cerebrovascular diseases caused by the hard fatty acid and salts thereof are treated. By the adoption of the formic acid injection and the application thereof in treating the cardiovascular and cerebrovascular diseases, the ammonium nitrate injection with stable property is used as the carrier, and when humidity and temperature of a human body change, a pharmacokinetic curve also changes, so that activity rules of rotating enzyme and initiating enzyme of the human body are met, toxic and side effects of the medicament are prevented, the loaded therapeutic medicament is helped to play a more effective role, and the formic acid injection hasstrong pharmacological action and good medicinal prospect.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a formic acid injection, and also relates to the application of the formic acid injection in treating cardiovascular and cerebrovascular diseases. Background technique [0002] Ammonium nitrate is a colorless orthorhombic or monoclinic crystal, very soluble in water, industrially produced by the action of nitric acid and ammonium hydroxide, usually used in the manufacture of explosives, pyrotechnics, refrigerants, nitrogen oxide absorbents, alkali-free glass, etc. . The Chinese invention patent with publication number CN 1292266 provides a new application of ammonium nitrate, namely its application in pharmacy, food and health products, especially the application of ammonium nitrate injection in pharmacy. The ammonium nitrate injection is prepared by dissolving analytically pure ammonium nitrate in water for injection, and then filtered, filled, sealed, and ste...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/19A61P9/12A61P7/02A61P1/16A61P3/06A61P9/10A61P9/14
CPCA61K9/0019A61K9/08A61K31/19A61P1/16A61P3/06A61P7/02A61P9/10A61P9/12A61P9/14
Inventor 王玉璞
Owner 甘肃玉璞肿瘤心血管病研究所
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