Shape memory bone repairing stent and preparation method thereof

A bone repair and memory technology, applied in the field of biomedicine, can solve the problems of lack of mechanical strength or mechanical brittleness, lack of pore size and pore interconnectivity, limited cell migration, etc., to reduce the risk of nonunion and high shape memory performance. Effect

Inactive Publication Date: 2019-07-19
THE HONG KONG POLYTECHNIC UNIV SHENZHEN RES INST
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, these injectable materials usually lack satisfactory mechanical strength or mechanical brittleness
Besides that, injectable m

Method used

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  • Shape memory bone repairing stent and preparation method thereof
  • Shape memory bone repairing stent and preparation method thereof
  • Shape memory bone repairing stent and preparation method thereof

Examples

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Embodiment 1

[0024] Embodiment 1, a shape-memory bone repair scaffold, used for bone defect repair, its raw materials include: HA, HDI, castor oil, PCL and water, wherein, the quality of the HA is the total mass of raw materials of the shape-memory bone repair scaffold The sum of the mass of the HA, the HDI and the castor oil is 17 to 35% of the total mass of the raw material, and the mass ratio of the castor oil, the HA to the PCL is 4 ~6:1~12:100; the molar ratio of the water to HDI is 1:2; the HDI equivalent / the PCL equivalent is 1.00.

[0025] Wherein, the HA is nano-sized hydroxyapatite powder with a thickness of 30-150 nm, and the molecular weight of the PCL is 2500-4500.

[0026] The present invention will be described in detail below through specific examples.

[0027] In the raw materials of Comparative Examples and Examples 1-4, the polycaprolactone diol (PCL) was selected from PCL3000, and the HA was selected from 20nm HA nanoparticles, and the PCL3000 was purchased from Persto...

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Abstract

The present invention discloses a shape memory bone repairing stent for bone defect repair. The shape memory bone repairing stent comprises the following raw materials: HA, HDI, castor oil, PCL and water, wherein mass of the HA mass is 1%-7% of a total mass of the shape memory bone repairing stent raw materials, a sum mass of the HA, the HDI and the castor oil is 17-35% of the total mass of the raw materials, a mass ratio of the castor oil, the HA to the PCL is (4.46-6):(1.1-8.4):100; a mass ratio of the water to the HDI is 1:(18-19); and the shape memory bone repairing stent has a pore diameter of 534 [mu]m-797 [mu]m, a porosity is 50%-60%, and pore interconnectivity is 95%-99%. The shape memory bone repairing stent is prepared by using a pre-polymer foaming method, has pore structure andmechanical properties similar to bone tissues, at the same time has high shape memory property, biocompatibility and biodegradability, is not limited to mold shapes, manufacturing technology and bonedefect shapes, can be highly compatible with bone defect sites, and promotes formations of new bones and new blood vessels.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a shape memory bone repair bracket and a preparation method thereof. Background technique [0002] Bone defects caused by trauma, congenital defects, or tumor resection will not heal without intervention. Although bone grafting is a standard clinical procedure to enhance or accelerate bone regeneration, autologous bone grafting has many disadvantages, especially the difficulty of closely fitting autografts and allografts to bone defect contours, increasing the risk of nonunion. In order to precisely shape scaffolds into close contact with adjacent bone tissue, traditional synthetic scaffolds are usually limited by their mold shape, post-fabrication shaping and complexity of fabrication techniques. In addition, injectable materials can be implanted minimally invasively as bone scaffold precursors, which can be used as surrogates (eg, hydrogels, ceramics, and glass-ceramics) t...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/50A61L27/36A61L27/18A61L27/00A61L27/12
CPCA61L27/00A61L27/12A61L27/18A61L27/3637A61L27/50A61L27/56A61L2400/12A61L2400/16A61L2430/02C08L67/04
Inventor 胡金莲张原驰谢瑞琪
Owner THE HONG KONG POLYTECHNIC UNIV SHENZHEN RES INST
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