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Preparation method of poria cocos extract for treatment of cerebral apoplexy and application

A Poria cocos extract and stroke technology are applied in the field of preparation of a Poria cocos extract for treating stroke, and achieve the effects of fast treatment effect, low manufacturing cost and rapid action

Pending Publication Date: 2019-09-06
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although global medical workers continue to develop various effective drugs and interventions for the treatment of ischemic stroke, the development and clinical application of single-component, single-target chemical drugs have encountered bottlenecks

Method used

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  • Preparation method of poria cocos extract for treatment of cerebral apoplexy and application
  • Preparation method of poria cocos extract for treatment of cerebral apoplexy and application
  • Preparation method of poria cocos extract for treatment of cerebral apoplexy and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] After 1 kg of Poria cocos is chopped, it is placed in a Chinese medicine multifunctional extraction tank. Add the extraction solvent according to the ratio of adding 8 liters of extraction solvent per 1 liter of Poria cocos. Carry out heating and reflux extraction. The extraction solvent is ethanol aqueous solution with ethanol volume percent concentration of 50%. Heating to reflux specifically means that after the extraction is boiled, the reflux extraction is continued in a slightly boiling state, and after reflux extraction for 2 hours, it is filtered to obtain the first extract.

[0039] Add 50% ethanol aqueous solution to the filter residue twice, heat and reflux for extraction twice, and the ratio of the volume of the extraction solvent to the volume of Poria cocos for each heating and reflux extraction is 8:1. The extraction time is 2 hours, and the second extraction solution and the third extraction solution are respectively obtained by filtering.

[0040] Th...

Embodiment 2

[0043] After 1 kg of Poria cocos is chopped, it is placed in a Chinese medicine multifunctional extraction tank. Add the extraction solvent according to the ratio of adding 10 liters of extraction solvent per 1 liter of Poria cocos. Carry out heating and reflux extraction. The extraction solvent is an aqueous ethanol solution with an ethanol volume percent concentration of 80%. Heating to reflux specifically means that after the extraction is boiled, the reflux extraction is continued in a slightly boiling state, and after reflux extraction for 2 hours, it is filtered to obtain the first extract.

[0044] Add 80% ethanol aqueous solution to the filter residue twice, heat and reflux for extraction twice, and the ratio of the volume of the extraction solvent to the volume of Poria cocos for each heating and reflux extraction is 10:1. The extraction time is 2 hours, and the second extraction solution and the third extraction solution are respectively obtained by filtering.

[...

Embodiment 3

[0048] After 1 kg of Poria cocos is chopped, it is placed in a Chinese medicine multifunctional extraction tank. Add the extraction solvent according to the ratio of adding 4 liters of extraction solvent per 1 liter of Poria cocos. Carry out heating and reflux extraction. The extraction solvent is ethanol aqueous solution with ethanol volume percent concentration of 20%. Heating to reflux specifically means that after the extraction is boiled, the reflux extraction is continued in a slightly boiling state, and after reflux extraction for 2 hours, it is filtered to obtain the first extract.

[0049] Add 20% ethanol aqueous solution to the filter residue twice, heat and reflux for extraction twice, and the ratio of the volume of the extraction solvent to the volume of Poria cocos for each heating and reflux extraction is 4:1. The extraction time is 2 hours, and the second extraction solution and the third extraction solution are respectively obtained by filtering.

[0050] Th...

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Abstract

The invention relates to a preparation method of a poria cocos extract for treatment of cerebral apoplexy and application. The preparation method includes steps: (1) adding, by volume, a part of poriacocos into a multifunctional traditional Chinese medicine extracting pot, adding, by volume, 4-10 parts of an extraction solvent, and performing heating reflux and reflux extraction to obtain extractliquid, wherein extraction time is 1-3 hours, the extraction solvent is one of or a mixture of at least two of ethyl alcohol, methyl alcohol and water, and when the extraction solvent is a mixture ofethyl alcohol and water, the volume percent concentration of ethyl alcohol is 20-80%; (2) concentrating and drying the extract liquid to obtain the poria cocos extract.

Description

technical field [0001] The present application relates to the technical field of traditional Chinese medicine, in particular to a preparation method and application of Poria cocos extract for treating cerebral apoplexy. Background technique [0002] Ischemic stroke, namely cerebral infarction, is an acute cerebrovascular disease with sudden onset, caused by ischemia, and characterized by focal neurological deficits, with high morbidity and high mortality , high disability rate and high recurrence rate. [0003] Recombinant tissue plasminogen activator (rt-PA) is still the only drug approved by the US Food and Drug Administration (FDA) for the treatment of acute ischemic stroke, but its The short treatment time window, side effects such as bleeding risk and neurotoxicity limit its wide clinical application. [0004] In recent years, studies have found that the pathological mechanism of neuronal damage after ischemia mainly involves the massive release of excitatory amino ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/076A61P9/10A61P7/04A61P25/00
CPCA61K36/076A61K2236/331A61K2236/333A61K2236/39A61P7/04A61P9/10A61P25/00
Inventor 范祥
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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