An easy-to-wear and focus-free miniature imaging system for experimental animals
A technology for experimental animals and imaging systems, which is applied in the field of easy-to-wear and focus-free micro-imaging systems for experimental animals, which can solve the problems of complex use process and large errors, and achieve the effects of simple operation, light weight and convenient use
Active Publication Date: 2021-03-05
ZHEJIANG UNIV
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Problems solved by technology
At present, the structure and use process of microscopic microscopes that can be worn by active animals are very complicated. It is necessary to continuously align and focus the microscope with the self-focusing lens that enters the experimental animal body, and the error is very large.
Method used
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[0026] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.
[0027] Such as figure 1 As shown, the present invention includes a micro-microscope 3, a self-focusing lens assembly 1 and a carrying device 2 sequentially connected from top to bottom;
[0028] Such as figure 2 As shown, the carrying device 2 is mainly composed of a sleeve 9 and a plurality of fixed feet 8 uniformly distributed along the circumference of the outer wall of the sleeve 9. The bottom of the fixed feet 8 is flush with the bottom of the sleeve 9; The adapter sleeve 14 of the lens assembly 1 is connected by thread.
[0029] Such as image 3 and 4 As shown, the self-focus lens assembly 1 includes a conversion base 5, an adapter sleeve 14, a glass sleeve 7 and an auto-focus lens 6; Composed of sleeve 14, the base 13 has a large hole 16 that communicates with the light exit hole 19 and runs through the base 13, the minia...
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The invention discloses an easy-to-wear and focus-free miniature imaging system for experimental animals. The invention includes a micro-microscope, a self-focusing lens assembly and a carrying device sequentially connected from top to bottom. The micro-imaging system uses a glass sleeve to fix the self-focusing lens on the lower part of the micro-microscope, and completes lens focusing during the fixing process to form an integrated The carrying device is fixed on the surface of the experimental animal. The light source of the miniature microscope passes through the main optical path, and enters the tissue or organ to be observed in the experimental animal to form imaging light, and then the imaging light returned by the self-focusing lens passes through the main optical path again. for imaging. The present invention can be fixed on the animal or removed from the animal through the carrying device at any time and in any physiological state of the experimental animal. At the same time, there is no need to focus on the lens in the optical path during the process, which is convenient for the experimenter under various physiological activities of the experimental animal. Experimental operation and microscopic imaging observation.
Description
technical field [0001] The invention belongs to the field of fluorescence microscopic imaging, in particular to an easy-to-wear and focus-free miniature imaging system for experimental animals. Background technique [0002] Bioimaging technology can provide intuitive and accurate image information on the physiological state and pathological changes of organisms at the tissue and cell levels. In the field of basic medicine, researchers often use model animals such as mice and rats combined with imaging technology to explore the physiological functions of tissues and organs and the occurrence and development of diseases. The commonly used imaging method in basic medical research at this stage is microscopic fluorescence imaging of tissue slices, that is, the imaging results are obtained under a wide-field fluorescence microscope or a fluorescence confocal microscope after a fixed section of a dead biological sample. However, this imaging method can only observe the samples of...
Claims
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IPC IPC(8): G02B21/00G02B21/02G02B21/24
CPCG02B21/0004G02B21/025G02B21/24G02B21/241
Inventor 斯科武泽楠龚薇
Owner ZHEJIANG UNIV