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A pharmaceutical composition for treating oral periodontal and mucosal diseases, its preparation method and use

A composition and drug technology, applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc., can solve the problems of less medicinal taste, clinical efficacy, high production cost, difficult to control impurity content, etc.

Active Publication Date: 2021-10-29
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above disclosed patents have good clinical curative effect in the treatment of periodontal disease and mucosal disease, but the above published patents have more medicinal flavors, higher production costs, and it is difficult to control the impurity content in industrialized mass production, so There is an urgent need for a pharmaceutical composition with less medicinal taste and significant clinical curative effect
At present, there is no relevant report on the treatment of oral inflammatory diseases with turmeric, coptis, and angelica.

Method used

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  • A pharmaceutical composition for treating oral periodontal and mucosal diseases, its preparation method and use
  • A pharmaceutical composition for treating oral periodontal and mucosal diseases, its preparation method and use
  • A pharmaceutical composition for treating oral periodontal and mucosal diseases, its preparation method and use

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Effect test

Embodiment 1

[0030] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0031] (1) Raw materials: Turmeric 5g, Coptidis 3g, Angelica dahurica 10g.

[0032] (2) Preparation method:

[0033] Step 1: Add 6 to 8 times the amount of medicinal materials in water and soak for 0.5 to 1 hour, then decoct for 0.5 to 1 hour, filter to obtain a water decoction, and use the dregs for later use.

[0034] Step 2: Add 6 to 8 times the amount of medicinal material to decoct the medicinal residue in step 1 for 1 to 1.5 hours, filter to obtain a decoction, and discard the medicinal residue.

[0035] Step 3: The water decoction in step 1 and step 2 is combined and concentrated into an extract, and then the extract is vacuum-dried to obtain a dry extract.

[0036] Step 4: Pulverize the dry paste prepared in step 3, add 30 g of auxiliary materials starch to granulate, 2 g of magnesium stearate, 20 g of dextrin, and 20 g of microcrystalline cellulose, uniformly prepare granule...

Embodiment 2

[0037] The preparation of embodiment 2 pharmaceutical composition of the present invention

[0038] (1) Raw materials: 20g of turmeric, 9g of Coptis chinensis, 25g of Angelica dahurica.

[0039] (2) Preparation method: after the dry paste obtained by the preparation method of Example 1 is pulverized, add 280 g of auxiliary materials starch to granulate, 20 g of magnesium stearate, 100 g of dextrin, and 100 g of microcrystalline cellulose, uniformly obtain granules, and press into tablets to obtain tablet.

Embodiment 3

[0040] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0041] (1) Raw materials: turmeric 25g, berberine 12g, angelica 30g.

[0042] (2) Preparation method: after the dry paste obtained by the preparation method of Example 1 is pulverized, add 260 g of auxiliary materials starch to granulate, 20 g of magnesium stearate, 100 g of dextrin, and 100 g of microcrystalline cellulose, uniformly obtain granules, and press into tablets to obtain tablet.

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Abstract

The invention provides a pharmaceutical composition for treating oral periodontal and mucosal diseases, which is prepared from raw materials in the following weight proportions: 5-60 parts of turmeric, 3-30 parts of Coptidis Rhizoma, 10-60 parts of Angelica dahurica . The invention further discloses the preparation method and application of the pharmaceutical composition. The pharmaceutical composition of the invention has good therapeutic effects on oral periodontal and mucosal diseases such as periodontitis, oral striae diseases, oral lichen planus and the like. The pharmaceutical composition of the present invention has the advantages of novel formula, simple composition, low cost, significant curative effect, no toxic and side effects, and not easy to produce tolerance, etc., and provides clinical treatment for patients with periodontitis, oral striae diseases, oral lichen planus, and oral leukoplakia. a new drug option.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a pharmaceutical composition for treating oral periodontal and mucosal diseases, a preparation method and application. Background technique [0002] With the improvement of people's life, more and more attention is paid to oral hygiene and oral disease care. The common oral periodontal diseases are periodontitis, gingivitis, etc.; the common oral mucosal diseases are oral lichen planus and oral leukoplakia. Wait. Although there are various treatment methods and medications in clinical practice, good results have not been achieved. [0003] Periodontal disease is a common and frequently-occurring disease of the oral cavity, which can lead to bleeding gums, periodontal pus, loose teeth and even tooth loss, seriously affecting chewing and digestive functions. At the same time, it is also a high-risk factor for cardiovascular disease, diabetes, and premature birth. Rega...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P1/02
CPCA61K36/232A61K36/718A61K36/9066A61P1/02A61K2300/00
Inventor 金钊左渝陵严航郑涛艾黄萍
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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