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A method for inhibiting photodegradation of ergothioneine and its application

An ergothioneine and photodegradation technology, which is applied in the field of ergothioneine-containing compositions for inhibiting photodegradation of ergothioneine, can solve problems such as easy decomposition of ergothioneine and unstable efficacy, and achieve inhibition of photodecomposition and good moisturizing Effects on Sexuality and Efficacy Stability

Active Publication Date: 2021-07-23
BLOOMAGE BIOTECHNOLOGY CORP LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the current problems that ergothioneine is easy to decompose when exposed to light and has unstable efficacy, the present invention provides a method that can effectively inhibit the photodegradation of ergothioneine

Method used

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  • A method for inhibiting photodegradation of ergothioneine and its application
  • A method for inhibiting photodegradation of ergothioneine and its application
  • A method for inhibiting photodegradation of ergothioneine and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Inhibitory effect of hyaluronic acid on photodegradation of ergothioneine

[0033] The degradation of ergothioneine-containing products during use was simulated under light conditions (1000Lux) to determine the inhibitory effect of hyaluronic acid on the photodegradation of ergothioneine.

[0034] Effects of Sodium Hyaluronate with Different Molecular Weights on the Photodegradation of Ergothioneine

[0035] Add 0.5% sodium hyaluronate with a molecular weight of 1200 kDa-1600 kDa, sodium hyaluronate with a molecular weight of 300 kDa-800 kDa, and sodium hyaluronate with a molecular weight of 3 kDa-10 kDa in the ergothioneine solution, Stir until the hyaluronic acid is completely dissolved, then add 2% v / v 1,3-butanediol and 3% v / v 1,2-pentanediol, then place it in a transparent plastic bottle and place it in a light incubator at 25°C The incubator photoperiod is 24:0 (light / dark). Samples were taken regularly every day to measure the change of ergothioneine ...

Embodiment 2

[0053] Embodiment 2 Preparation of ergothioneine-containing composition

[0054] Weigh different raw materials according to the following ratio:

[0055]

[0056] Prepare according to the following steps:

[0057] Take sodium hyaluronate with a molecular weight of 1200 kDa-1600 kDa and sodium hyaluronate with a molecular weight of 300 kDa-800 kDa, add water and heat to 85°C and stir to dissolve the sodium hyaluronate. After the sodium hyaluronate is completely dissolved, cool down to 45°C. ℃, then add sodium hyaluronate and ergothioneine extract with a molecular weight of 3 kDa-10 kDa in the formula and stir evenly to obtain sample S1;

[0058] Take sodium hyaluronate with a molecular weight of 1200 kDa-1600 kDa and a molecular weight of 300 kDa-800 kDa respectively, add water and heat to 85°C and stir to dissolve the sodium hyaluronate. After the sodium hyaluronate is completely dissolved, cool down to 45°C, and then add Stir the ergothioneine extract in the prescribed a...

Embodiment 3

[0062] Antioxidant activity of embodiment 3 composition

[0063] Samples S1-4, C1, and C2 prepared in Example 2 were placed in transparent plastic bottles, and placed in a light incubator (1000 Lux) at 25°C for 5 days, or stored in the dark for 5 days before use.

[0064] free radical scavenging test

[0065] Dissolve the illuminated samples S1-4, C1, and C2 prepared in Example 2 and the non-illuminated S1, C1, and C2 in water respectively, and prepare solutions with the final concentrations of the above samples at 2.0%, 4.0%, 6.0%, and 8.0%. spare. Accurately measure 5.0 mL of the DPPH solution and 5.0 mL of the sample solution prepared in Example 2 with different concentrations respectively, put them in a stoppered test tube, and mix them evenly. Adjust to zero with an equal volume of 95% ethanol-water mixed solution. Stand at room temperature for 30 minutes, measure the absorbance value of the solution at 523 nm, and repeat each concentration three times; another group w...

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Abstract

The invention provides a method for inhibiting the photodegradation of ergothioneine and its application, comprising the following steps: adding hyaluronate in a solution containing ergothioneine; the content of the ergothioneine is 0.0005-0.01wt%; The content of hyaluronate is more than 0.1 wt%. The invention combines hyaluronate and ergothioneine, which can effectively inhibit the photodecomposition of ergothioneine, and the composition can be used in food health products or cosmetics, has good moisturizing effect and stable efficacy.

Description

technical field [0001] The invention belongs to the field of biochemical industry and relates to a method for inhibiting the photodegradation of ergothioneine, in particular to a composition containing ergothioneine and its application. Background technique [0002] Ergothioneine (ergothioneine) is a rare natural amino acid discovered in 1909 in a fungus Claviceps purpurea. Existing studies have found that ergothioneine exists in many animals and plants, and has important physiological activities in the body. Studies have shown that it has many functions such as scavenging free radicals, anti-inflammation, maintaining DNA biosynthesis, normal cell growth and cellular immunity. a physiological function. [0003] There are three methods for the preparation of ergothioneine: chemical synthesis, extraction and microbial fermentation. It is very difficult to synthesize L-ergothioneine by chemical methods. However, the content of ergothioneine extracted from natural biological ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/49A61K8/73A61Q19/00A61Q19/08A61Q19/02A61Q17/04A23L33/175A23L33/10A23L2/38
CPCA23L2/38A23V2002/00A61K8/4946A61K8/735A61Q17/04A61Q19/00A61Q19/02A61Q19/08A23L33/10A23L33/175A23V2200/30A23V2250/06
Inventor 魏玉洁陆震贾玉倩陈雯雯毛华孙元军郭文逸石艳丽郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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