The invention discloses an imrecoxib
solid preparation and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations, the
solid preparation comprises the following components by
mass: 15-25% of imrecoxib, 10-40% of pea
maltodextrin, 10-40% of Soluplus, 1-3% of
poloxamer, 10-30% of a filler, 10-20% of a disintegrating agent, 0.8-1.2% of a flow aid and 0.8-1.2% of a
lubricant. Through synergistic interaction of triple carriers, Soluplus inhibits
drug crystallization by means of
hydrogen bonds and promotes dispersion; the
poloxamer reduces the
surface tension and improves the
dispersity and the
dissolution rate; the pea
maltodextrin plays an anti-oxidation role, improves the
sphericity, fluidity and stability of the particles, and is low in cost. Aiming at the difficulties that imrecoxib is low in
solubility, easy to oxidize and the like,
medicine dissolution is remarkably improved, related substances are more stable, and both process robustness and
cost control are considered.