A composition for regulating skin collagen metabolism and its application

A technology of collagen and composition, which is applied in the field of composition regulating skin collagen metabolism, which can solve the problems of skin damage to human body, harm to human body, poor light stability, etc., and achieve the effect of improving compatibility

Active Publication Date: 2022-05-17
广州茱颜化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chlorogenic acid in plants can greatly absorb ultraviolet rays, known as the "ultraviolet absorber" of plants, 10% chlorogenic acid is added to the formula, SPF 0h 10.13, SPF 2h 2.17; PFA 0h The value is 5.89, PFA 2h The value of chlorogenic acid is 1.86, the sun protection effect of chlorogenic acid is good, but its photostability is poor, and it will decompose under the action of light, and produce free radicals or intermediate products harmful to human body. Long-term use will cause damage to the skin and even the human body, limiting its application

Method used

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  • A composition for regulating skin collagen metabolism and its application
  • A composition for regulating skin collagen metabolism and its application
  • A composition for regulating skin collagen metabolism and its application

Examples

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Effect test

Embodiment 1

[0040] A composition for regulating skin collagen metabolism, which is composed of a modified cyclodextrin and an anti-aging regulator, and the weight ratio of the modified cyclodextrin and the anti-aging regulator is 15:1;

[0041] The preparation method of the composition for regulating skin collagen metabolism is as follows: 2 g of the anti-aging regulator is dissolved in 100 ml of absolute ethanol, 30 g of modified cyclodextrin is added with water and stirred to obtain a saturated aqueous solution of modified cyclodextrin, and the anti-aging regulator The ethanol solution is slowly added dropwise to the modified cyclodextrin aqueous solution. After the addition is completed, continue to stir for 60 minutes, refrigerate at 0-5°C for 30 hours, filter, and dry to obtain the composition.

Embodiment 2

[0043] A composition for regulating skin collagen metabolism, which is composed of a modified cyclodextrin and an anti-aging regulator, and the weight ratio of the modified cyclodextrin and the anti-aging regulator is 10:1;

[0044] The preparation method of the composition for regulating skin collagen metabolism is as follows: 2 g of the anti-aging regulator is dissolved in 100 ml of absolute ethanol, 20 g of modified cyclodextrin is added with water and stirred to obtain a saturated aqueous solution of modified cyclodextrin, and the anti-aging regulator The ethanol solution is slowly added dropwise to the modified cyclodextrin aqueous solution. After the addition is complete, continue to stir for 30 minutes, refrigerate at 0-5°C for 24 hours, filter, and dry to obtain the composition.

Embodiment 3

[0046] A composition for regulating skin collagen metabolism, which is composed of a modified cyclodextrin and an anti-aging regulator, and the weight ratio of the modified cyclodextrin and the anti-aging regulator is 12:1;

[0047] The preparation method of the composition for regulating skin collagen metabolism is as follows: 2 g of the anti-aging regulator is dissolved in 100 ml of absolute ethanol, 24 g of modified cyclodextrin is added with water and stirred to obtain a saturated aqueous solution of modified cyclodextrin, and the anti-aging regulator The ethanol solution is slowly added dropwise to the modified cyclodextrin aqueous solution. After the addition is complete, continue to stir for 40 minutes, refrigerate at 0-5°C for 25 hours, filter, and dry to obtain the composition.

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Abstract

The invention discloses a composition for regulating skin collagen metabolism and its application. The composition is composed of modified cyclodextrin and an anti-aging regulator. The preparation of modified cyclodextrin is based on alcohol on β-cyclodextrin Hydroxyl and stearic acid are obtained by esterification reaction under the action of an acid catalyst, and a long chain of hydrophobic fat is introduced into the β-cyclodextrin. The modified β-cyclodextrin not only has hydrophilicity but also has certain Lipophilicity, the formation of more hydrophobic holes in the modified cyclodextrin makes it easier to form inclusion complexes with guest molecule anti-aging regulators, which can be applied to cosmetics to improve the compatibility of inclusion complexes with other components. It is easier to emulsify to form a uniform emulsion. In addition, the form of inclusion compound ensures the stability of the anti-aging regulator and effectively inhibits the photolysis of the anti-aging regulator. When applied to cosmetics, it avoids secondary damage to the skin , maintain the thickness of the dermis and the content of total skin collagen, and delay skin aging.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a composition for regulating skin collagen metabolism and an application thereof. Background technique [0002] As the ozone layer becomes thinner, more and more ultraviolet rays reach the ground. The intensity of ultraviolet rays contained in sunlight is very high. In summer, when the sun shines directly on the skin, ultraviolet rays are most likely to penetrate the surface of the skin. Ultraviolet rays can not only produce melanin, darken the skin, but also There is a possibility of skin aging. When the skin is exposed to excessive ultraviolet rays, it will damage the epidermal cells. Most of the damage caused by sunlight is caused by ultraviolet radiation with a wavelength of 200 to 400nm. Among them, UVC with a wavelength of less than 290nm is basically absorbed by the ozone layer and cannot reach the ground; UVB with a wavelength of 290 to 320nm can cause burn...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/73A61K8/49A61Q19/08C07D473/04
Inventor 盘锐伦刘欣
Owner 广州茱颜化妆品有限公司
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