Traditional Chinese medicine active component composition having effect of raising content of leucocyte

A technology for increasing leukocytes and active ingredients, applied in the field of traditional Chinese medicine active ingredient compositions for the treatment of leukopenia, can solve problems such as expensive side effects of new drugs, increase leukocytes, and inaccurate treatment effects, and achieve good promotion value, increase High leukocyte activity, significant curative effect

Active Publication Date: 2019-10-15
SHANXI UNIV
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Problems solved by technology

[0004] In order to solve the problems of inaccurate treatment effect of traditional medicines, high price of new medicines and obvious side effects in current medicines for leukopenia, the present invention provides a Chinese medicine active ingredient composition with the effect of increasing leukocytes

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  • Traditional Chinese medicine active component composition having effect of raising content of leucocyte
  • Traditional Chinese medicine active component composition having effect of raising content of leucocyte
  • Traditional Chinese medicine active component composition having effect of raising content of leucocyte

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Embodiment Construction

[0012] In order to make the objects and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the examples. The specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0013] ICR mice were weighed, numbered, and randomly divided into blank control group, model group, single-component experimental group, group combination experimental group and positive drug Lvjiao Buxue Granules group (LJG). On the 1st day of the experiment, the model was established. The mice in the model group were intraperitoneally injected with cyclophosphamide 80 mg / kg to establish the leukopenia model. The mice in the normal group were given an equal volume of sterilized water for injection for 3 consecutive days. The single-component experimental group, the combination experimental group and the LJG group were given corresponding drugs for 7 days on the basis of th...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and provides a traditional Chinese medicine active component composition having the effect of raising the content of leucocyte in order to solve the problems that the treatment effects of traditional medicines are not precise and novel medicines are high in price and have obvious side effects in present leucopenia medications. The traditional Chinese medicine active component composition having the effect of raising the content of leucocyte is prepared through mixing two or three of ferulic acid namely FA in radix angelica sinensis, astragaloside namely AST in radix astragali and atractylenolide I namely AO-I in bighead atractylodes rhizomes. Under the optimal compatibility combination, every two components are in compatibility or the three components are in compatibility, so that the contents of the leucocyte and bone marrow DNA of a leucopenia animal model can be notably raised (P is smaller than 0.01), which illustrates that the traditional Chinese medicine active component composition disclosed by the invention has notable treatment effects in the respect of treating leucopenia and has good promotion value.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine active ingredient composition with the effect of increasing white blood cells, which is used for treating leukopenia. Background technique [0002] Leukopenia refers to the continuous white blood cell count in peripheral blood <4.0×10 9 / L, is a common blood disease, often manifested as weakness, palpitations, dizziness, limp limbs, insomnia and dreaminess. When white blood cell count < 2.0×10 9 / L, the absolute value of neutrophils <0.5×10 9 / L, manifested as sudden headache, joint pain, extreme fatigue, etc., severe cases even have symptoms such as dysphagia, and the mortality rate is extremely high. [0003] The main therapeutic chemical drugs for leukopenia include traditional drugs lithium carbonate and vitamin B4, and new drug colony-stimulating factors. However, the therapeutic effect...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K31/7048A61K31/365A61P7/00
CPCA61K31/192A61K31/7048A61K31/365A61P7/00A61K2300/00
Inventor 向欢颜磊王晶晶陈安平田俊生
Owner SHANXI UNIV
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