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The technical method of hair follicle melanocyte stem cell transplantation in the treatment of vitiligo

A melanocyte and stem cell technology, applied in the field of hair follicle melanocyte stem cell transplantation for the treatment of vitiligo, can solve the problems of inability to treat the hair in the complex area, long course of treatment, easy recurrence, etc., to promote proliferation and differentiation and tissue formation, Guaranteed efficacy

Active Publication Date: 2021-01-12
NANHAI RENSHU INT SKIN HOSPITAL (HAINAN) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Vitiligo is an acquired skin and mucous membrane pigmentation disorder. The color recovery of skin lesions is mostly completed by the migration of melanocytes from other parts and the production of pigments. The repigmentation patterns of vitiligo skin lesions can be summarized as punctate, marginal, and uniform Vitiligo can be completely cured only by achieving punctate recoloration. The common treatment methods for vitiligo in clinical practice mainly include traditional Chinese medicine treatment, corticosteroid and other western medicine treatment, photochemical therapy (308 excimer laser) and epidermis transplantation. , the first two treatment measures vary from person to person, and if Chinese medicine is used for treatment, the course of treatment is long and the curative effect is uncertain. At the same time, some patients have relatively large side effects after taking the medicine, such as nausea, vomiting, loss of appetite, etc. , as for the treatment of corticosteroid hormones, the curative effect is unstable and easy to relapse; epidermal transplantation, one of the commonly used methods at present, is unstable and easy to relapse because of the uniform recoloration; 308 excimer laser treatment cycle is long, the curative effect is average, and the side effects are large , even if the recoloring effect is unstable, and the color is not uniform, the disadvantages of the existing technology: (1) can only achieve pigment regeneration around a single hair follicle, and a large number of hair follicle transplants are needed to recolor, and the treatment of vitiligo with moderate area or more cannot be completed; (2) After hair follicle implantation, it is impossible to deal with the hair growing in the recolored area, and to treat the head, face and body hypertrichosis. Therefore, the technical method of hair follicle melanocyte stem cell transplantation for the treatment of vitiligo is provided, and the existing problems are further improved. Improve

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  • The technical method of hair follicle melanocyte stem cell transplantation in the treatment of vitiligo
  • The technical method of hair follicle melanocyte stem cell transplantation in the treatment of vitiligo

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Embodiment 1

[0029] Such as figure 1 As shown, the present invention provides a kind of technical scheme: the technical method of hair follicle melanocyte stem cell transplantation treatment vitiligo, this technical method comprises the following steps:

[0030] Step S1, hair follicle extraction, using FUE technology to extract a hair follicle unit;

[0031] Step S2, separating the hair follicles, separating the hair follicle units into individual hair follicles under an electron microscope;

[0032] Step S3, the in vitro culture of hair follicles, put the extracted and isolated individual hair follicles into special culture medium for cultivation and standby, and cultivate to improve the survival rate of hair follicles;

[0033] Step S4, inactivation of hair follicles, inactivating hair follicles before transplantation with the aid of a dermatoscope and a hair follicle inactivation needle;

[0034] Step S5, transplantation of hair follicles. After the hair follicles are inactivated, the...

Embodiment 2

[0042] Such as figure 2 As shown, the technical method of hair follicle melanocyte stem cell transplantation provided by the present invention for the treatment of vitiligo, through the technical method in Example 1, transplants hair follicle melanocyte stem cells to specific areas of leukoplakia, promotes the proliferation and differentiation of melanocytes and organizes The formation of point-like multiple hair follicles can be achieved, so as to achieve the purpose of fast whitening.

[0043] In this example, the cure rate of vitiligo treated by hair follicle melanocyte stem cell transplantation reached over 95%.

[0044] Technical difficulties and operation steps of the present invention:

[0045]Technical difficulties: "Survival rate" refers to whether the melanocyte stem cells can survive directly after planting, which is related to the later treatment effect, and the autologous melanocyte stem cells obtained after extraction have the characteristics of not being affec...

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Abstract

The invention discloses a technical method for treating vitiligo with hair follicle melanocyte stem cell transplantation. The technical method comprises the following steps: extracting hair follicles, using FUE technology to extract a hair follicle unit; separating hair follicles, separating the hair follicle unit under an electron microscope Single hair follicles are produced; for in vitro culture of hair follicles, the extracted and isolated single hair follicles are cultured in a special culture medium for future use to improve the survival rate of hair follicles; for the inactivation of hair follicles, use a dermatoscope and a hair follicle inactivation needle to treat the hair follicles before transplantation. The hair follicles are inactivated; the hair follicles are transplanted, and after the hair follicles are inactivated, the special planting needles are used to precisely plant them in the specific area of ​​the leukoplakia. The present invention adopts the in vitro culture technology of hair follicles, and adopts the FUE technology to extract and isolate a single hair follicle, and put it into a special culture medium for cultivation. Through the hair follicle inactivation technology, the hair follicles are inactivated. After the operation, only the hair will turn black and no hair will grow. Through precise planting, the recoloration of multiple hair follicles in the form of spots can be realized, so as to achieve the purpose of rapid whitening.

Description

technical field [0001] The invention relates to the technical field of hair follicle transplantation, in particular to a technical method for treating vitiligo with hair follicle melanocyte stem cell transplantation. Background technique [0002] Vitiligo is an acquired skin and mucous membrane pigmentation disorder. The color recovery of skin lesions is mostly completed by the migration of melanocytes from other parts and the production of pigments. The repigmentation patterns of vitiligo skin lesions can be summarized as punctate, marginal, and uniform Vitiligo can be completely cured only by achieving punctate recoloration. The common treatment methods for vitiligo in clinical practice mainly include traditional Chinese medicine treatment, corticosteroid and other western medicine treatment, photochemical therapy (308 excimer laser) and epidermis transplantation. , the first two treatment measures vary from person to person, and if Chinese medicine is used for treatment, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/36A61P17/00C12N5/071
CPCA61K35/36A61P17/00C12N5/0625
Inventor 刘景卫
Owner NANHAI RENSHU INT SKIN HOSPITAL (HAINAN) CO LTD
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