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Method for evaluating quality of rhizoma nardostachyos medicinal materials based on 1H-NMR

A 1H-NMR, quality evaluation technology, applied in the direction of using nuclear magnetic resonance for analysis, can solve the problem of no simultaneous detection and analysis of multiple types of components, and achieve the effect of simplifying variables and simplifying data structure

Pending Publication Date: 2019-10-18
甘孜藏族自治州林业科学研究所
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Problems solved by technology

[0004] The purpose of the present invention is to provide a 1 The H-NMR quality evaluation method of Gansong medicinal materials, this method solves the problem that there is no method for simultaneous detection and analysis of multiple components at present, and can simultaneously detect and analyze a variety of Gansong medicinal materials

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  • Method for evaluating quality of rhizoma nardostachyos medicinal materials based on 1H-NMR

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Embodiment 1

[0040] The components of Nardinosa medicinal materials from different origins were tested. The sources of Nardonia medicinal materials in different origins are detailed in Table 1. They mainly come from Ganzi Prefecture, Sichuan Province, and have been identified as the dried roots and rhizomes of Nardostachys jatamansi Dc.

[0041] Table 1 Sources of Gansong medicinal materials from different origins

[0042]

[0043] This detection method is based on 1 H-NMR, specific detection methods include:

[0044] Take 0.20g of dried medicinal powder, weigh it accurately, place it in a conical flask, add 1mL CD 3 OD and 0.3mLD 2 O solution (containing 12.32mg / mLKH 2 PO 4 and 0.04% TSP), sealed, ultrasonically extracted for 30min, taken out, let cool, passed through a 0.45μm microporous membrane, took 0.60mL filtrate into a standard 5mm NMR tube, and carried out 1 H-NMR determination.

[0045]With deuterated methanol as the frequency interlock, Bruker 400MHz nuclear magnetic re...

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Abstract

The invention discloses a method for evaluating the quality of rhizoma nardostachyos medicinal materials based on 1H-NMR. The method comprises the following steps: by taking deuterated methanol as a frequency internal lock, carrying out 1H-NMR detection on the rhizoma nardostachyos medicinal materials; carrying out Fourier transformation on a detected 1H-NMR free induction decay signal to correctchemical shift, carrying out sectional integral on a spectrum in a range of 0.70-8.50ppm, and carrying out normalization processing by a total peak area to obtain signal peak area values correspondingto chemical shift sections; and deducting a signal of a methanol solvent and a peak signal of residual water, and carrying out multivariate statistical analysis on deducted data: forming a matrix bythe deducted data, carrying out scale normalization processing on the matrix, carrying out principal component analysis, and classifying the rhizoma nardostachyos medicinal materials in different production places. According to the method disclosed by the invention, a metabonomics technology is adopted; the 1H-NMR fingerprint spectrums of the rhizoma nardostachyos medicinal materials are established for the first time; and meanwhile, the overall chemical components of the rhizoma nardostachyos medicinal materials are detected and analyzed.

Description

technical field [0001] The invention relates to a method for evaluating the quality of medicinal materials, in particular to a method based on 1 H-NMR quality evaluation method of Gansong medicinal materials. Background technique [0002] Gansong is the dry root and rhizome of Nardostachys jatamansi Dc., a plant of the family Patellaceae. It is pungent, sweet, and warm in nature. Loss of appetite, vomiting embolism. Modern pharmacological studies have shown that Gansong medicinal materials have many functions such as antiarrhythmia, sedation, antiepileptic, anticonvulsant, antidepressant, antimyocardial ischemia, lowering blood pressure, antispasmodic, and antibacterial. In addition to medicinal use, it is also widely used in food, cosmetics and other fields, and has high economic value and development prospects. [0003] At present, a variety of compounds have been isolated from the medicinal material of Gansong, which can be divided into terpenoids, flavonoids, coumarin...

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Application Information

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IPC IPC(8): G01N24/08
CPCG01N24/08
Inventor 余海清伍杰彭克忠兰常军刘韩吴富雨夏苗刘燕云
Owner 甘孜藏族自治州林业科学研究所
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