Medicinal composition with effect of promoting healing of skin wound of patient receiving radiotherapy and preparation method thereof

A wound healing and composition technology, which is applied in the field of skin healing drugs, can solve the problems of lack of drugs for skin wound healing of patients with radiotherapy, increase psychological and economic pressure, and increase patient pain, etc., so as to promote skin wound healing, accelerate healing, and easily attractive effect

Inactive Publication Date: 2019-11-01

尹洪莉 +1

2 Cites 1 Cited by

AI-Extracted Technical Summary

Problems solved by technology

[0005] In summary, there are problems in the prior art: after radiotherapy for tumor patients, the radiation causes a certain radiation reaction and damage to the normal skin tissue of the human body, and there ...

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Method used

In the embodiment of the present invention, vitamin is vitamin A, multivitamin B and vitamin C, and vitamin A has the effect of regulating epidermis and stratum corneum metabolism, can resist aging, removes wrinkles; Helps to protect epidermis, and mucous membrane is not subject to bacteria Violation, healthy skin, prevent skin cancer; vitamin B complex can treat pellagra and ...

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Abstract

The invention discloses a medicinal composition with an effect of promoting healing of a skin wound of a patient receiving radiotherapy and relates to the technical field of skin healing medicines. The medicinal composition with the effect of promoting healing of a skin wound of a patient receiving radiotherapy is prepared from the following components by weight: 1-10g of purslane, 1-10g of dandelion, 1-10g of radix astragali, 1-10g of common bletilla tubers, 1-10g of coptidis rhizoma, 1-10g of pseudo-ginseng, 8*10<-6>-20*10<-6>g of vitamins, 0.01-0.02g of zinc, 2-10g of lactobacillus reuteri,2-10g of lactobacillus rhamnosus, 20-50g of chitosan and dressing, wherein the vitamins are one or more of vitamin A, vitamin B and vitamin C; and the dressing is pharmaceutically acceptable auxiliaries which do not accounting for 30-50 percent of the dressing. The medicinal composition is applied or sprayed to a radiation injured skin after the patient receives radiotherapy, can be used for promoting skin healing of the patient and is suitable for clinical popularization and application.

Application Domain

Inorganic active ingredientsPharmaceutical delivery mechanism +4

Technology Topic

DrugVitamin b +9

Image

Examples

Experimental program(4)

Example Embodiment

[0048] Example 1

[0049] like figure 1 Shown, the preparation method of the pharmaceutical composition that promotes radiation therapy patient's skin wound healing in the embodiment of the present invention, comprises the following steps:

[0050] Step 1. Obtain the extracts of purslane, dandelion, astragalus, bletilla striata, coptis and notoginseng by water extraction or alcohol extraction. Add a certain proportion and concentration of ethanol or distilled water into the beaker, and carry out reflux extraction after a water bath at a certain temperature to obtain the water-extracted or alcohol-extracted extract of the above-mentioned raw materials;

[0051] Step 2, mixing the above drug extracts uniformly, adding vitamins and zinc at 4-10°C and mixing uniformly to obtain a mixture;

[0052] Step 3, using microemulsion technology or microcapsule technology, combining the above drug mixture with an appropriate amount of chitosan, supplemented with gelatin and auxiliary materials in an appropriate proportion to form a drug film.

[0053] Before the microemulsification and microcapsules, Lactobacillus reuteri and Lactobacillus rhamnosus are added to the mixed solution to adjust the pH value to 5.5-6.4, the ratio of gelatin to chitosan is 1.6-3.6, and the content of the drug film is The dosage is 5-8%.

[0054] Firstly, the purslane, dandelion, astragalus, bletilla striata, coptis and notoginseng are extracted by water extraction or alcohol extraction to obtain extracts, and the extracts obtained by alcohol extraction are usually better;

[0055] Mix the remaining components in the extract, add Lactobacillus reuteri and Lactobacillus rhamnosus to adjust the relevant pH value, add chitosan and gelatin to the mixture according to the proportion, on the one hand chitosan is in the Chinese medicine extract It has a certain clarification effect, which can keep the effective ingredients and remove impurities. It is prepared as a film by using microemulsification technology or microcapsule technology. Bacillus, chitosan has obvious mucoadhesion in acidic environment, and also has the effect of maintaining permeability, because chitosan non-woven fabric has better air permeability.

Example Embodiment

[0056] Example 2

[0057] The pharmaceutical composition for promoting skin wound healing of radiotherapy patients of the present invention consists of purslane 2g, dandelion 2g, astragalus 2g, bletilla striata 2g, coptis 2g, notoginseng 2g, vitamin 9 × 10 by weight -6 g, zinc 0.01g, Lactobacillus reuteri 10g, Lactobacillus rhamnosus 2g and chitosan 30g; Film preparation is prepared by the preparation method of the pharmaceutical composition of the promotion radiation therapy patient skin wound healing of above-mentioned embodiment 1;

[0058] The vitamin is one or more of vitamin A, vitamin B complex and vitamin C;

[0059] The purslane, dandelion, astragalus, bletilla striata, coptis and notoginseng are extracts of purslane, dandelion, astragalus, bletilla striata, coptis and notoginseng extracted by water or alcohol;

[0060] When in use, sprayed on the skin wounds of radiotherapy patients, it can quickly form a film, promote wound healing, promote drug absorption, and inhibit bacteria at the same time.

Example Embodiment

[0061] Example 3

[0062] The pharmaceutical composition for promoting skin wound healing of radiotherapy patients of the present invention consists of purslane 8g, dandelion 8g, astragalus 8g, bletilla striata 8g, coptis 8g, notoginseng 8g, vitamin 15 × 10 by weight -6 g, zinc 0.02g, Lactobacillus reuteri 10g, Lactobacillus rhamnosus 2g and chitosan 50g, the film preparation is prepared by the preparation method of the pharmaceutical composition for promoting skin wound healing of radiotherapy patients in the above-mentioned embodiment 1.

[0063] The vitamin is one or more of vitamin A, vitamin B complex and vitamin C;

[0064] The purslane, dandelion, astragalus, bletilla striata, coptis and notoginseng are extracts of purslane, dandelion, astragalus, bletilla striata, coptis and notoginseng extracted by water or alcohol.

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Description & Claims & Application Information

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Medicinal composition with effect of promoting healing of skin wound of patient receiving radiotherapy and preparation method thereof

AI-Extracted Technical Summary

Problems solved by technology

Method used

Abstract

Image

Examples

Example Embodiment

Example Embodiment

Example Embodiment

PUM

Description & Claims & Application Information

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