In vivo drug delivery devices and methods for drug delivery

A technology for delivering devices and medicines, applied in the directions of medicine delivery, medicine devices, medicine formulations, etc., can solve the problems of lack of desired biocompatibility, stability, sterilization, manufacturability, wall thickness, flexibility, etc.

Pending Publication Date: 2019-11-05
TARIS BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such configurations that rely on diffusion may limit the drug release kinetics that can be achieved and / or may limit the range of suitable materials of construction to those lacking desired biocompatibility, stability, sterilability, and including manufacturability, Material for mechanical properties such as wall thickness, flexibility, etc.

Method used

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  • In vivo drug delivery devices and methods for drug delivery
  • In vivo drug delivery devices and methods for drug delivery
  • In vivo drug delivery devices and methods for drug delivery

Examples

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example 1

[0158] A device prototype with a central laser-drilled orifice was fabricated and loaded with trospium chloride tablets. One set of devices contained two gasket apertures at each end (ie, a plug with a longitudinal aperture formed therein), while a second set of devices had two restrictive plugs at the ends. exist Figure 11 and 12 A schematic diagram of the prototype is shown in . Figure 11 The device in has three drug release openings: two at opposite ends and one on the side wall. The drug reservoir lumen of the device has an inner diameter of 2.64 mm and a wall thickness of 0.2 mm. The wall has a hardness of 50A. Figure 12 The device in has a release opening, plus two opposing ends capable of providing release when the hydrostatic pressure is sufficient to form a microchannel. The drug reservoir lumen of the device has an inner diameter of 2.64 mm and a wall thickness of 0.2 mm. The wall has a hardness of 50A.

[0159] The device was placed in a container of deion...

example 2

[0161] The device shown in Fig. 3 was fabricated in the following manner. The device is a dual-lumen silicone tube with a laser-machined orifice, a polymeric bismuth-coated tube to contain the drug and form a one-way valve at each end of the drug compartment in the drug lumen. A silicone elastomer plug of toluene C, and a white silicone adhesive used to hold the plug in place in the large lumen, a preformed superelastic nitinol circular section resistant to the lumen of the retaining frame filament, and retaining lumen ends sealed with a translucent silicone adhesive. The drug is formulated as a drug containing trospium chloride (active pharmaceutical ingredient), povidone (polyvinylpyrrolidone (PVP)) K29 / 32 (adhesive excipient) and polyethylene glycol 8000 (lubricant excipient) tablet. Each device contains 850 mg of trospium chloride. The device is small in size (less than 5 cm in the long axis), flexible and contoured in order to minimize potential allergies and inflammat...

example 3

[0165] Following the parameters in Table 1, a trospium chloride releasing intravesical device was fabricated for in vitro release characterization. The device was fabricated using one of two types of silicone housing components. One type (RW) comprises an annular tube with a wall thickness of 0.2 mm and a durometer of 5OA defining a drug reservoir lumen. Another type (TW) comprises an annular tube with a wall thickness of 0.4mm and a durometer of 35A defining a drug reservoir lumen. Both types of silicone parts have a drug reservoir lumen inner diameter of 2.64 mm. All devices had a 150 μm diameter laser drilled orifice approximately centered on the sidewall of the silicone part. The system is assembled with plugs of different lengths. The system either contains two plugs, one at each end, or one plug with a gasket on the other end of the system to seal that end of the reservoir (i.e., so that microchannels cannot form on that end. ). The drug reservoir lumen of each syst...

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Abstract

Drug delivery devices and methods of administering drugs to patients are provided. A device (50) includes a reservoir (60) containing a drug (58). The reservoir (60) is defined by a wall (64) having awater-permeable portion, such that the water-permeable portion permits water to enter the device (50) and contact the drug (58). A restraining plug (56) closes off an opening of the device (50) suchthat transient microchannels (62) form between an elastic portion (54) of the device (50) and the restraining plug (56), upon the generation of a sufficient pressure within the reservoir (60), to release the drug (58) from the device (50). Methods of treating patients for neurogenic detrusor overactivity resulting from a spinal cord injury and/or for idiopathic overactive bladder and urinary incontinence are also described.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority to U.S. Provisional Application Nos. 62 / 453,333, filed February 1, 2017, and 62 / 480,744, filed April 3, 2017, the contents of which are incorporated herein by reference. Background technique [0003] The present disclosure relates generally to medical devices that may be deployed in the body for controlled drug delivery, and more particularly to such devices having a water permeable wall portion and one or more for providing controlled drug release from the device. [0004] Many current drug delivery devices rely on one or more orifices on the sidewall or end of the device to allow drug release therefrom. However, such orifices, particularly those provided on the sidewalls of the device, may be susceptible to encrustation and clogging after the drug delivery device is deployed in a patient. A clogged orifice is undesirable as it typically results in less reproducible drug ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M31/00A61K9/00
CPCA61K9/0004A61M31/002A61K9/0034A61M25/0043A61M25/0017A61M2025/0057A61M2210/1085A61M31/00A61M2205/04A61M37/0069A61M2205/0216
Inventor 李喜真埃米莉·阿巴特莎拉·霍金丹尼斯·吉辛
Owner TARIS BIOMEDICAL
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