Industrial-grade cis-propenyl phosphoric acid analysis method
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- WUHAN INSTITUTE OF TECHNOLOGY
- Publication Date
- 2019-11-22
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention belongs to the technical field of chemical analysis and detection, and in particular relates to an analysis method of industrial grade cis-acrylophosphate. Background technique
[0002] Fosfomycin sodium is a new type of broad-spectrum antibiotic. Its bactericidal mechanism is to inhibit the early synthesis of bacterial cell walls. The chance of anaphylactic shock is very small. It is mainly used to treat infections of the urinary tract, skin, soft tissue and intestinal tract. , has a strong bactericidal effect on most Gram-positive bacteria and Gram-negative bacteria, and is widely used clinically and has a large market demand. Among them, (1R,2S)-(-)-cis-1,2-epoxypropylphosphonic acid (R)-(+)-α-phenethylamine salt, referred to as left phosphorus and right amine salt, is a synthetic fosfomycin It is an important intermediate of element, which is usually prepared by hydrogenation of cis-propylene phosphate, and its impurity content direc...