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Application of 2,5-furan dimethanol in preparing antitumor drugs

An anti-tumor drug, a technology of furandimethanol, which is applied in the field of medicine, can solve problems such as none, and achieve the effects of less toxic and side effects, mild toxic and side effects, and low difficulty in obtaining

Pending Publication Date: 2019-12-17
遵义医科大学珠海校区
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there is no relevant data on the pharmacological activity and toxicity of 2,5-furandimethanol at home and abroad, and there is no report on whether 2,5-furandimethanol has the effect of inducing apoptosis in cancer cells, let alone 2,5-furandimethanol. The precedent of furandimethanol used in the preparation of antitumor drugs

Method used

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  • Application of 2,5-furan dimethanol in preparing antitumor drugs
  • Application of 2,5-furan dimethanol in preparing antitumor drugs
  • Application of 2,5-furan dimethanol in preparing antitumor drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Cytotoxicity test of 2,5-furandimethanol on human neuroblastoma SH-SY5Y:

[0025] SH-SY5Y was purchased from the National Experimental Cell Resource Sharing Service Platform (3111C0001CCC000026).

[0026] Complete medium: 100mL complete medium contains 89.1mL RPMI-1640 medium, 9.9mL fetal bovine serum and 1mL penicillin-streptomycin solution. In the penicillin-streptomycin solution, the content of penicillin is 10KU / mL, and the concentration of streptomycin is 10mg / mL.

[0027] Replace medium: Use a pipette to remove the complete medium in the culture bottle, wash the cells 2-3 times with 2-3mL PBS solution (phosphate buffered saline), add 4mL fresh complete medium, and store at 37°C, CO 2 Continue culturing in a cell culture incubator with a content of 5%.

[0028] Subculture: Use a pipette to remove the medium in the culture flask, wash the cells 2-3 times with 2-3mL PBS solution, add 500μL trypsin containing 0.25% EDTA to digest for 1-2min, discard the trypsin; add...

Embodiment 2

[0038] Cytotoxicity test of 2,5-furandimethanol on human lung cancer cell A549:

[0039] A549 was purchased from the National Experimental Cell Resource Sharing Service Platform (3111C0001CCC000002).

[0040] Complete medium: 100mL complete medium contains 89.1mL RPMI-1640 medium, 9.9mL fetal bovine serum and 1mL penicillin-streptomycin solution.

[0041] Replace medium: Use a pipette to remove the medium in the culture bottle, wash the cells with 2-3mL PBS solution 2-3 times, add 4mL fresh complete medium, and store at 37°C, CO 2 Continue culturing in a cell culture incubator with a content of 5%.

[0042] Passage: Use a pipette to remove the medium in the culture flask, wash the cells with 2-3mL PBS solution 2-3 times, add 500μL of trypsin containing 0.25% EDTA to digest for 1-2min, discard the trypsin, and add 3mL of complete medium Stop the digestion, mix by pipetting, keep 1mL liquid in the culture bottle and add 3mL fresh complete medium, at 37℃, CO 2 The culture was ...

Embodiment 3

[0053] Cytotoxicity test of 2,5-furandimethanol on human gastric adenocarcinoma cell SGC7901:

[0054] SGC7901 was purchased from the National Experimental Cell Resource Sharing Service Platform (3111C0001CCC000236).

[0055] Complete medium: 100mL complete medium contains 89.1mL RPMI-1640 medium, 9.9mL fetal bovine serum and 1mL penicillin-streptomycin solution.

[0056] Change medium: Use a pipette to remove the medium in the culture bottle, wash the cells with 2-3mL PBS solution 2-3 times, add 4mL fresh complete culture medium at 37°C, CO 2 Continue culturing in a cell culture incubator with a content of 5%.

[0057] Passage: Use a pipette to remove the medium in the culture flask, wash the cells with 2-3mL PBS solution 2-3 times, add 500μL of trypsin containing 0.25% EDTA to digest for 1-2min, discard the trypsin, and add 3mL of complete medium Stop the digestion, mix by pipetting, keep 1mL liquid in the culture bottle and add 3mL fresh complete medium, at 37℃, CO 2 The...

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Abstract

The invention belongs to the field of medicine, and discloses application of 2,5-furan dimethanol in preparing antitumor drugs. The tumors comprise neuroblastoma, lung cancer, gastric adenocarcinoma,and colorectal adenocarcinoma. An antitumor drug includes 2,5-furan dimethanol. The antitumor drug also includes pharmaceutically acceptable adjuvants. The administration mode of the antitumor drug isoral administration or injection. The invention discloses for the first time a new medical use of 2,5-furan dimethanol, and 2,5-furan dimethanol can be used for preparing antitumor drugs, and provides a new way and measure for treating the tumors. The invention points out that 2,5-furan dimethanol has small toxic and side effects, can produce significant inhibitory effect on various types of tumors, and has a good clinical application value.

Description

technical field [0001] The invention belongs to the field of medicine, and particularly relates to the application of 2,5-furandimethanol in the preparation of antitumor drugs. Background technique [0002] Tumor is one of the multiple serious diseases that seriously endanger human health. There are better medical treatment methods for early tumors, but for malignant tumors, the main treatment is to improve the quality of life and prolong the survival time of patients, and it is difficult to completely eradicate it. No recurrence. Although many major achievements have been made in the research of anti-tumor drugs in recent decades, most of the anti-tumor drugs currently used clinically kill both tumor cells and normal body cells, which not only affects the therapeutic effect but also affects the tumor. The patient suffered a great deal. Therefore, people still need to continue to devote themselves to the research and development of new antitumor drugs. [0003] 2,5-furand...

Claims

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Application Information

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IPC IPC(8): A61K31/341A61P35/00
CPCA61K31/341A61P35/00
Inventor 冯昆侯亚男郑春辉王雅溶
Owner 遵义医科大学珠海校区
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