Method for detecting escitalopram in blood

A technology for blood and blood samples, applied in measurement devices, instruments, scientific instruments, etc., can solve the problems of long detection time, low blood sample detection efficiency, long time, etc., and achieve high sensitivity, good sample recovery rate, and improved accuracy. degree of effect

Inactive Publication Date: 2020-01-03
BEIJING HARMONY HEALTH MEDICAL DIAGNOSTICS CO LTD
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  • Abstract
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Problems solved by technology

The detection time of blood samples is low due to the long time of extraction processing, which makes the detection time long

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  • Method for detecting escitalopram in blood
  • Method for detecting escitalopram in blood
  • Method for detecting escitalopram in blood

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Embodiment Construction

[0040]In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments It is a part of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work belong to the protection of the present invention. scope.

[0041] The method for detecting escitalopram in blood of the present invention comprises the following steps:

[0042] (1) Calibration of standard solution

[0043] (a) preparation of escitalopram standard stock solution

[0044] Accurately weigh 10 mg of escitalopram standard substance and place it in a 10mL volumetric flask, dissolve it with pure met...

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Abstract

The invention provides a method for detecting escitalopram in blood. The method comprises the following steps of preparing a standard stock solution of the escitalopram, preparing a standard intermediate solution of the escitalopram, preparing an internal standard working solution, preparing a standard solution and detecting the standard solution by using a liquid chromatography-gas chromatograph-mass spectrometer, and fitting to obtain a standard curve equation corresponding to the escitalopram, wherein the standard curve equation is y1=a*x1+b; and processing the blood to be tested, detectingthe blood to be tested by using the liquid chromatography-gas chromatograph-mass spectrometer, and calculating the concentration of the escitalopram in the blood to be tested. According to the methodfor detecting the escitalopram in the blood provided by the invention, a processing method of a blood sample to be tested and the selection of an internal standard substance enable the recognition ofthe escitalopram to be more accurate, the analysis time is short, the interference is small, the internal standard is quantitative and suitable, the specificity is strong, and the sensitivity is high; and meanwhile, all technical indexes such as the recovery rate, the detection limit and the precision meet the requirements, so that the accuracy of a detection result is improved, and system errorsare eliminated.

Description

technical field [0001] The invention relates to the technical field of biological detection, in particular to a method for detecting escitalopram in blood. Background technique [0002] Escitalopram is the left-handed enantiomer of racemic citalopram, which is a selective serotonin reuptake inhibitor. Its mechanism of action is to enhance the serotonin (5-HT) energy of the central nervous system and inhibit 5-HT reuptake. It is widely used clinically in the treatment of major depressive disorder (MDD) and generalized anxiety, so the monitoring of escitalopram has important clinical significance. [0003] Currently, high-performance liquid chromatography is commonly used to test blood samples from patients taking escitalopram. However, when the escitalopram content in the blood sample is detected by the above method, the blood sample needs to be pretreated, for example, extracted. Since the extraction process usually takes a long time, the detection time is long and the de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/89G01N30/04G01N30/72G01N30/86G01N30/06G01N30/14
CPCG01N30/04G01N30/06G01N30/14G01N30/72G01N30/8634G01N30/89G01N2030/042G01N2030/045
Inventor 雒琴贾永娟倪君君
Owner BEIJING HARMONY HEALTH MEDICAL DIAGNOSTICS CO LTD
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